Biological and functional evaluation of a novel pyrolytic carbon implant for the treatment of focal osteochondral defects in the medial femoral condyle: assessment in a canine model

BACKGROUND: Osteochondral defects continue to be a clinical treatment challenge, and when left untreated, may cause pain and functional impairment. Pyrolytic carbon is a unique isotropic biomaterial used in heart valve and small joint replacements due to its excellent wear properties and biocompatibility with bone and articular cartilage. Therefore, a proposed solution is to utilize a focal pyrolytic carbon hemiarthroplasty implant as an alternative resurfacing treatment strategy for isolated cartilage lesions. METHODS: A canine model (n = 9) was used to evaluate the in vivo histologic response and function of a pyrolytic carbon implant replacing a full-thickness osteochondral defect in the medial femoral condyle (MFC) of the knee. The gross appearance and histologic results were compared to an identical cobalt-chromium (Co-Cr) alloy implant placed in a defect in the contralateral MFC and evaluated up to 52 weeks. RESULTS: Extensive bone incorporation to the stem portion was observed for both implant types. The total mean histologic score for the cartilage of the MFC surrounding the pyrolytic carbon implants was significantly improved compared to that of the Co-Cr alloy implants at all evaluation periods (p < 0.05). Histologic grading and gross observations at 52 weeks for pyrolytic carbon implants were similar to those of Co-Cr alloy implants at 24 weeks. At 24 weeks, the mean total histologic score for Co-Cr alloy implants was 11.6 ± 0.7 (0–16 range point; 16 = normal appearance), while at 52 weeks, the mean total score for the pyrolytic carbon implants was 11.7 ± 1.3. Mean total histologic score of opposing medial tibia cartilage for the pyrolytic carbon implants was superior to that of the Co-Cr alloy group at all evaluation periods and significantly improved over the Co-Cr alloy implant group at 24 weeks (p = 0.001) and 52 weeks (p < 0.001). CONCLUSIONS: Use of a pyrolytic carbon implant for reconstruction of a focal cartilage defect demonstrated effective implant fixation and superior in vivo response compared to an identical Co-Cr alloy implant

Continuous variable quantum key distribution with two-mode squeezed states

Quantum key distribution (QKD) enables two remote parties to grow a shared key which they can use for unconditionally secure communication [1]. The applicable distance of a QKD protocol depends on the loss and the excess noise of the connecting quantum channel [2-10]. Several QKD schemes based on coherent states and continuous variable (CV) measurements are resilient to high loss in the channel, but strongly affected by small amounts of channel excess noise [2-6]. Here we propose and experimentally address a CV QKD protocol which uses fragile squeezed states combined with a large coherent modulation to greatly enhance the robustness to channel noise. As a proof of principle we experimentally demonstrate that the resulting QKD protocol can tolerate more noise than the benchmark set by the ideal CV coherent state protocol. Our scheme represents a very promising avenue for extending the distance for which secure communication is possible.Comment: 8 pages, 5 figure

Examining the Impact of Stress on Collegiate Flight Students

Stress may negatively affect the timely completion of a student pilot\u27s flight training. A student pilot influenced by stress may be subject to what is known as falling behind the aircraft, a condition that constantly requires minor interventions from their flight instructor. This lack of situational awareness and decreased performance may inadvertently cause the student pilot to repeat the flight lesson, increasing the time spent in the training course

Frontal alpha asymmetry neurofeedback for the reduction of negative affect and anxiety

Frontal alpha asymmetry has been proposed to underlie the balance between approach and withdrawal motivation associated to each individual's affective style. Neurofeedback of EEG frontal alpha asymmetry represents a promising tool to reduce negative affect, although its specific effects on left/right frontal activity and approach/withdrawal motivation are still unclear. The present study employed a neurofeedback training to increase frontal alpha asymmetry (right - left), in order to evaluate discrete changes in alpha power at left and right sites, as well as in positive and negative affect, anxiety and depression. Thirty-two right-handed females were randomly assigned to receive either the neurofeedback on frontal alpha asymmetry, or an active control training (N = 16 in each group). The asymmetry group showed an increase in alpha asymmetry driven by higher alpha at the right site (p < 0.001), as well as a coherent reduction in both negative affect and anxiety symptoms (ps < 0.05), from pre-to post-training. No training-specific modulation emerged for positive affect and depressive symptoms. These findings provide a strong rationale for the use of frontal alpha asymmetry neurofeedback for the reduction of negative affect and anxiety in clinical settings

The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology.

Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+) homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca(2+) uniporter complex

Lower-Body Strength Relationships with Sprint, Jump, and Sport-Specific Skill Performance in High School Girls Softball Players

International Journal of Exercise Science 17(4): 86-98, 2024. Softball athletes require multiple fitness traits (e.g., strength, speed, power) and sport-specific skills (e.g., hitting, throwing) for success. Lower-body strength could underpin these qualities; this has received little analysis among high school female athletes. This research investigated correlations between absolute and relative lower-body strength with age, linear speed, lower-body power, and throwing and hitting velocity in high school girls softball athletes. Archival data collected from 34 high school girls softball players (age=14.91±1.00 years; height=1.66±0.07 m; body mass=63.21±9.59 kg) from a private strength and conditioning facility was analyzed. The data included: age, height, and body mass; 0-9.14 and 0-18.29 m sprint interval times; standing broad jump (SBJ) distance (lower-body power); batted ball exit (i.e., hitting) and throwing velocity; and absolute and relative three-repetition maximum (3RM) front squat and hexagonal bar deadlift (HBD). Pearson’s correlations (p\u3c0.05) derived relationships between absolute and relative strength with the fitness and sport-specific tests. The results indicated significant relationships between the 3RM HBD with age (r=0.389) and hitting velocity (r=0.418). The 3RM front squat related to the SBJ (r=0.422) and hitting velocity (r=0.457). Relative 3RM HBD correlated with the 0-18.29 m sprint interval (r=–0.349). These results suggested that a strength and conditioning program that improves the lower-body strength of high school girls softball players could contribute to faster sprinting speed, further horizontal jumps, and greater hitting velocity. The results from this study highlights the value of strength enhancement in high school girls softball athletes and provides support for strength and conditioning program provision for these individuals

A case study of management shortcomings: Lessons from the B737-Max aviation accidents

This case study looked into the shortcomings in of Boeing’s upper management in the engineering and fielding of the B737-Max. Under pressure to build a plane with identical flying characteristics to the existing B737 family, Boeing included modifications but purposely concealed those changes from regulators and pilots. This decision resulted in fatal accidents in 2018 and 2019 and caused the deaths of 346 passengers. Unlike previous aviation accidents, these mishaps were entirely preventable and a direct result of Boeing’s organizational failures and management shortcomings. This case study analyzed the behavior, decision making process, and reasons which led Boeing to push for the certification of the B737-Max despite these known flaws in the design. Additionally, this poster studied the consequences and punitive actions that followed the investigation of the two crashes. The poster concludes by offering recommendations to the aviation industry on how accidents such as this can be avoided in the future

Impaired flow-induced arterial remodeling in DOCA-salt hypertensive rats

Arteries from young healthy animals respond to chronic changes in blood flow and blood pressure by structural remodeling. We tested whether the ability to respond to decreased (-90%) or increased (+100%) blood flow is impaired during the development of deoxycorticosterone acetate (DOCA)-salt hypertension in rats, a model for an upregulated endothelin-1 system. Mesenteric small arteries (MrA) were exposed to low blood flow (LF) or high blood flow (HF) for 4 or 7 weeks. The bioavailability of vasoactive peptides was modified by chronic treatment of the rats with the dual neutral endopeptidase (NEP)/endothelin-converting enzyme (ECE) inhibitor SOL1. After 3 or 6 weeks of hypertension, the MrA showed hypertrophic arterial remodeling (3 weeks: media cross-sectional area (mCSA): 10 +/- 1 x 10(3) to 17 +/- 2 x 10(3) mu m(2); 6 weeks: 13 +/- 2 x 10(3) to 24 +/- 3 x 10(3) mu m(2)). After 3, but not 6, weeks of hypertension, the arterial diameter was increased (empty set: 385 +/- 13 to 463 +/- 14 mu m). SOL1 reduced hypertrophy after 3 weeks of hypertension (mCSA: 6 x 10(3) +/- 1 x 10(3) mu m(2)). The diameter of the HF arteries of normotensive rats increased (empty set: 463 +/- 22 mu m) but no expansion occurred in the HF arteries of hypertensive rats (empty set: 471 +/- 16 mu m). MrA from SOL1-treated hypertensive rats did show a significant diameter increase (empty set: 419 +/- 13 to 475 +/- 16 mu m). Arteries exposed to LF showed inward remodeling in normotensive and hypertensive rats (mean empty set between 235 and 290 mu m), and infiltration of monocyte/ macrophages. SOL1 treatment did not affect the arterial diameter of LF arteries but reduced the infiltration of monocyte/ macrophages. We show for the first time that flow-induced remodeling is impaired during the development of DOCA-salt hypertension and that this can be prevented by chronic NEP/ECE inhibition. Hypertension Research (2012) 35, 1093-1101; doi:10.1038/hr.2012.94; published online 12 July 201

Analytical Fuselage and Wing Weight Estimation of Transport Aircraft

A method of estimating the load-bearing fuselage weight and wing weight of transport aircraft based on fundamental structural principles has been developed. This method of weight estimation represents a compromise between the rapid assessment of component weight using empirical methods based on actual weights of existing aircraft, and detailed, but time-consuming, analysis using the finite element method. The method was applied to eight existing subsonic transports for validation and correlation. Integration of the resulting computer program, PDCYL, has been made into the weights-calculating module of the AirCraft SYNThesis (ACSYNT) computer program. ACSYNT has traditionally used only empirical weight estimation methods; PDCYL adds to ACSYNT a rapid, accurate means of assessing the fuselage and wing weights of unconventional aircraft. PDCYL also allows flexibility in the choice of structural concept, as well as a direct means of determining the impact of advanced materials on structural weight. Using statistical analysis techniques, relations between the load-bearing fuselage and wing weights calculated by PDCYL and corresponding actual weights were determined