ANALYSIS OF MORPHOLOGICAL PARAMETERS OF DENTAL SYSTEM WITH GNATHIC FORM OF MALOCCLUSION CLASS III USING SIMPLYCEPH SOFTWARE (RUSSIA)

Mesiocclusion associated with asymmetric mandibular development is a gnathic form of mesiocclusion characterized by asymmetric deformation of the facial skeleton, requiring detailed examination to perform differential diagnostics. We need to analyze lateral teleroentgenogram of the head using «SimplyCeph» software, frontal teleroentgenogram of the head, multidetector computed tomography. According to scientific data, asymmetric mandibular development is much rarer in clinical practice. Etiology of this abnormality is not determined to date. It is believed that growth zones are activated in condyloid process and mandibular angle for unknown reasons. Aim - to determine the morphological condition of stomatognathic system on the stages of rehabilitation after complex treatment of patients with asymmetric growth of mandible. Materials and methods. We examined 40 patients with malocclusion class III aged from 16 to 40. The examined group included patients with malocclusion class III that corresponded to the certain degree of severity of the abnormality: Grade I - joining of the first permanent molars and canines for Class II Angle, displacement value does not exceed 1/2 of the first permanent molar cusp. Sagittal overjet is absent; the value of anterior crossbite is minimal, moderate or deep. Results. During the stages of rehabilitation of patients with malocclusion class III and asymmetry of the mandible it is necessary to conduct a comprehensive study of facial and gnathic areas of dental system, analyze the results of radiodiagnosis of sagittal, transversal and vertical skull parameters. Conclusion. Method of subcondylar vertical osteotomy helps to normalize the morphological state of dental system. Keywords: malocclusion class III, computer program «SimplyCeph», analysis of lateral teleroentgenogram

Molecular targets of CD45 in B cell antigen receptor signal transduction.

Abstract Expression of the phosphotyrosine phosphatase CD45 is essential for B cell Ag receptor (BCR)-mediated p21ras activation and calcium mobilization. To examine the molecular basis of this requirement, we analyzed signaling events following BCR ligation in CD45-deficient (CD45-) and CD45-reconstituted (CD45+) variants of J558Lmicrom3 cells. Ag stimulation resulted in tyrosine phosphorylation of cellular proteins in both cells. However, the spectrum of proteins phosphorylated in the CD45+ cells was qualitatively and/or quantitatively distinct from that in the CD45- cells. Among the protein tyrosine kinases examined, the Src family kinases Fyn and Blk were inducibly tyrosine phosphorylated and activated by receptor ligation only in CD45+ cells. While Ag-induced Btk tyrosine phosphorylation occurred in both cells, its activation was greatly diminished in the CD45- cells. Analysis of specific effector molecules revealed that tyrosine phosphorylation of Shc, but not rasGAP or Vav, correlated with the unique ability of BCR ligation to trigger p21ras activation in CD45+ cells. BCR-mediated Shc phosphorylation and recruitment of Grb2 depended on CD45 expression. Thus, Shc tyrosine phosphorylation may be the primary CD45-dependent mechanism by which Ag receptors are coupled to the p21ras pathway in J558Lmicrom3. In addition, phospholipase Cgamma1 (PLCgamma1) and PLCgamma2 were tyrosine phosphorylated upon Ag stimulation in CD45- cells, despite much reduced inositol trisphosphate production and lack of calcium mobilization. These findings suggest that CD45 may modulate events other than PLCgamma phosphorylation, which regulate phosphoinositide hydrolysis and the calcium mobilization response following BCR ligation.</jats:p

A-12 Relationships between Performance on the Virtual Environment Grocery Store and Adaptive Functioning among Older Adults

Abstract Background/Problem Neuropsychologists are often asked to evaluate patients’ functional capacities, yet traditional neuropsychological tests have limited correspondence with real-world outcomes. The Virtual Environment Grocery store (VEGS) is a virtual environment that stimulates shopping tasks. Previous research has found support for the construct validity of the VEGS among older adults (Parsons &amp; Barnett, 2017); however, no extant research has examined relationships between the VEGS and adaptive functioning among older adults. Method Older adults (n = 30; age 43–90 M = 77.09, SD = 12.94) were administered the Virtual Reality Grocery Store (VEGS) and the Texas Functional Living Scale (TFLS) and completed the Instruments of Daily Activities (IADLS) Questionnaire. Results VEGS variables explained 39.6% of the variance in self-reported adaptive functioning (I, e., the IADLS) and 60.0% of the variance in performance-based adaptive functioning (i.e., the TFLS). Conclusion These results suggest that the VEGS is a predictor of adaptive functioning – particularly when measured with a performance-based measure – among older adults. </jats:sec

A-168 Neural Network for the Virtual Environment Grocery Store for Detection of Neurocognitive Impairment among Older Adults

Abstract Objective Virtual reality-based neuropsychological tests offer the ability to capture a variety of data while enabling standardized administration. The purpose of this study was to create an artificial neural network to examine the predictability of the Virtual Environment Grocery Store (VEGS) for neurocognitive impairment among older adults. Method Older adults (N = 71; age 55–90, M = 74.38, SD = 8.32; 13 with a neurocognitive diagnosis and 58 without) completed the VEGS as part of a neuropsychological evaluation. Results The multilayer perceptron found a model which had a 3.4% error rate. The VEGS sum of the learning trials was the most important predictor of this model (i = 0.45). Conclusion Results suggest that the VEGS is sensitive to detecting neurocognitive impairment among older adults, with the sum of the learning trials making a substantial contribution to the model’s accuracy. </jats:sec

Surface Modifications of Love Acoustic Waves Sensors for Chemical and Biological Detection

The surface functionalization of guided-SH-SAW (Shear Horizontal-Surface Acoustic Wave) transducers was carried out to prepare layers for heavy metals chelation and antibodies recognition. For the preparation of the chemical sensors, a thiourea molecule acting as a chelating agent for heavy metals was grafted on the top-layer of the transducer. This covalent immobilization was obtained by amide bonds through primary amine groups immobilized on the device by the chemisorption of the 3-aminopropyltriethoxysilane (APTES). The thiourea modified transducer was inserted in a microfluidic analysis system to test its sensitivity for cadmium ions in liquid media. In the aim to develop bio-chemical sensors based on antigen/antibody recognition, a functionalization way based on SAMs of semicarbazide functions leading to alpha-oxo-semicarbazone bonds with antigenic peptides is described. The real-time immobilization of the peptide on the surface was observed for the first time and the antibody recognition was successfully monitored. Based on these results, the gravimetric determination by guided-SH-SAW transducers functionalized by the semicarbazide/alpha-oxo-aldehyde chemistry is a promising complementary route for antibodies analysis

ANALYSIS OF MORPHOLOGICAL PARAMETERS OF DENTAL SYSTEM WITH GNATHIC FORM OF MALOCCLUSION CLASS III USING SIMPLYCEPH SOFTWARE (RUSSIA)

Mesiocclusion associated with asymmetric mandibular development is a gnathic form of mesiocclusion characterized by asymmetric deformation of the facial skeleton, requiring detailed examination to perform differential diagnostics. We need to analyze lateral teleroentgenogram of the head using «SimplyCeph» software, frontal teleroentgenogram of the head, multidetector computed tomography. According to scientific data, asymmetric mandibular development is much rarer in clinical practice. Etiology of this abnormality is not determined to date. It is believed that growth zones are activated in condyloid process and mandibular angle for unknown reasons. Aim - to determine the morphological condition of stomatognathic system on the stages of rehabilitation after complex treatment of patients with asymmetric growth of mandible. Materials and methods. We examined 40 patients with malocclusion class III aged from 16 to 40. The examined group included patients with malocclusion class III that corresponded to the certain degree of severity of the abnormality: Grade I - joining of the first permanent molars and canines for Class II Angle, displacement value does not exceed 1/2 of the first permanent molar cusp. Sagittal overjet is absent; the value of anterior crossbite is minimal, moderate or deep. Results. During the stages of rehabilitation of patients with malocclusion class III and asymmetry of the mandible it is necessary to conduct a comprehensive study of facial and gnathic areas of dental system, analyze the results of radiodiagnosis of sagittal, transversal and vertical skull parameters. Conclusion. Method of subcondylar vertical osteotomy helps to normalize the morphological state of dental system. Keywords: malocclusion class III, computer program «SimplyCeph», analysis of lateral teleroentgenogram.</jats:p