5,825 research outputs found

    The ATLAS Forward Physics Program

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    The potential of forward physics measurements at ATLAS is presented. A brief description of the ZDC and LHCf is given, along with the dedicated luminosity system, LUCID and ALFA. The physics measurements include low luminosity elastic and diffractive measurements using the existing forward detectors and upgraded proton tagging at high luminosity to search for new physics

    Forward Physics at ATLAS

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    Presentation on behalf of ATLAS at Low-x 200

    Proceedings of the workshop "Standard Model at the LHC" University College London 30 March - 1 April 2009

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    Proceedings from a 3-day discussion on Standard Model discoveries with the first LHC dataComment: 9 contributions to the proceedings of the LHC Standard Model worksho

    Trapped and marginally trapped surfaces in Weyl-distorted Schwarzschild solutions

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    To better understand the allowed range of black hole geometries, we study Weyl-distorted Schwarzschild solutions. They always contain trapped surfaces, a singularity and an isolated horizon and so should be understood to be (geometric) black holes. However we show that for large distortions the isolated horizon is neither a future outer trapping horizon (FOTH) nor even a marginally trapped surface: slices of the horizon cannot be infinitesimally deformed into (outer) trapped surfaces. We consider the implications of this result for popular quasilocal definitions of black holes.Comment: The results are unchanged but this version supersedes that published in CQG. The major change is a rewriting of Section 3.1 to improve clarity and correct an error in the general expression for V(r,\theta). Several minor errors are also fixed - most significantly an incorrect statement made in the introduction about the extent of the outer prison in Vaidya. 17 pages, 2 figure

    Nano-structured morphological features of pulsed direct current magnetron sputtered Mo films for photovoltaic applications

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    Historically, molybdenum thin films have been used as the back contact for Cu(In,Ga)Se2 based solar cells and as such the properties of these layers play an important role in the overall cell structure. This paper describes the production of molybdenum films using pulsed d.c magnetron sputtering from compressed molybdenum powder targets. The films were deposited at different substrate temperatures under constant power and constant current modes, and analysed using X-ray diffraction, scanning electron microscopy, atomic force microscopy and four point resistance probe. Mechanical strain and resistivity were found to decrease with substrate temperature together with a shift in the (110) crystallographic plane towards higher diffraction angles. All films were well adhered to the glass substrates irrespective of their high tensile strain. Surface morphology analysis revealed the presence of nano-structured stress relief patterns which can enhance the nucleation sites for subsequent CuInSe2 deposition. A high-resolution cross sectional image showed the columnar growth of the films. Surface roughness analysis revealed that roughness increased with increase in substrate temperature

    Spectral ageing analysis of the double-double radio galaxy J1453+3308

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    We present new radio observations at frequencies ranging from 240 to 4860 MHz of the well-known, double-double radio galaxy (DDRG), J1453+3308, using both the Giant Metrewave Radio Telescope (GMRT) and the Very Large Array (VLA). These observations enable us to determine the spectra of the inner and outer lobes over a large frequency range and demonstrate that while the spectrum of the outer lobes exhibits significant curvature, that of the inner lobes appears practically straight. The break frequency, and hence the inferred synchrotron age of the outer structure, determined from 16-arcsec strips transverse to the source axis, increases with distance from the heads of the lobes. The maximum spectral ages for the northern and southern lobes are \sim47 and 58 Myr respectively. Because of the difference in the lengths of the lobes these ages imply a mean separation velocity of the heads of the lobes from the emitting plasma of 0.036c for both the northern and southern lobes. The synchrotron age of the inner double is about 2 Myr which implies an advance velocity of \sim0.1c, but these values have large uncertainties because the spectrum is practically straight.Comment: 10 pages, 10 figures, 5 tables, accepted for publication in MNRA

    Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

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    © The Author(s) 2016. Acquired resistance to conventional and targeted therapies is becoming a major hindrance in cancer management. It is increasingly clear that cancer cells are able to evolve and rewire canonical signalling pathways to their advantage, thus evading cell death and promoting cell invasion. The Axl receptor tyrosine kinase (RTK) has been shown to modulate acquired resistance to EGFR-targeted therapies in both breast and lung cancers. Glioblastoma multiforme (GBM) is a highly infiltrative and invasive form of brain tumour with little response to therapy. Both Axl and EGFR have been identified as major players in gliomagenesis and invasiveness. However, the mechanisms underlying a potential signalling crosstalk between EGFR and Axl RTKs are unknown. The purpose of this study was to investigate this novel and unconventional interaction among RTKs of different families in human GBM cells. With the use of western blotting, in vitro kinase activity, co-immunoprecipitation and bimolecular fluorescence complementation assays, we show that EGF stimulates activation of Axl kinase and that there is a hetero-interaction between the two RTKs. Through small interfering RNA knockdown and quantitative PCR screening, we identified distinct gene expression patterns in GBM cells that were specifically regulated by signalling from EGFR-EGFR, Axl-Axl and EGFR-Axl RTK parings. These included genes that promote invasion, which were activated only via the EGFR-Axl axis (MMP9), while EGFR-EGFR distinctly regulated the cell cycle and Axl-Axl regulated invasion. Our findings provide critical insights into the role of EGFR-Axl hetero-dimerisation in cancer cells and reveal regulation of cell invasion via Axl as a novel function of EGFR signalling

    Transport behavior of holes in boron delta-doped diamond structures

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    Boron delta-doped diamond structures have been synthesized using microwave plasma chemical vapor deposition and fabricated into FET and gated Hall bar devices for assessment of the electrical characteristics. A detailed study of variable temperature Hall, conductivity, and field-effect mobility measurements was completed. This was supported by Schr€dinger-Poisson and relaxation time o calculations based upon application of Fermi’s golden rule. A two carrier-type model was developed with an activation energy of 0.2eVbetweenthedeltalayerlowestsubbandwithmobility0.2 eV between the delta layer lowest subband with mobility 1 cm2/Vs and the bulk valence band with high mobility. This new understanding of the transport of holes in such boron delta-doped structures has shown that although Hall mobility as high as 900 cm2/Vs was measured at room temperature, this dramatically overstates the actual useful performance of the device
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