Open Piping: Towards an Open Visual Workflow Environment

The most popular visual programming tools focus on procedural, object-oriented and event-based programming. This paper describes a boxes-and-wires functional programming tool, aimed to be accessible to novice programmers, while also supporting open access to the specified processes, executable programs and results for study and deployment

Only God Decides\u27: Young Children\u27s Perceptions of Divorce and the Legal System

Objective: To describe research on perceptions of children aged 6 and younger from 21 families of their parents\u27 divorce, of its impact on their families, and of legal officials. Method: Semistructured play interviews were conducted during home visits as parents were conjointly interviewed as part of a larger study on divorce in legal context. Results: Children had much misinformation about divorce as an event and process. What they did know was often inappropriate, frightening, and confusing. They resented how the process \u27ruined their parents\u27 being friends any more\u27 and proposed reforms based on their wishes and observations. Conclusions: Greater awareness is needed of the child\u27s desire to be heard during the process, to feel safe and less lonely, and to stay in touch with both parents and extended families. Age-appropriate explanations of psychological and legal aspects of the divorce process are likely to support children\u27s positive adjustment and mental health

Is The Use Of Kinesio Tape (KT) Effective In Reducing Pain Postoperative Anterior Cruciate Ligament (ACL) Surgery?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not is the use of Kinesio Tape (KT) effective in reducing pain post-operative anterior cruciate ligament (ACL) surgery. STUDY DESIGN: Review of three randomized control trial studies that were published between 2013 and 2017 in peer reviewed journals. Two articles were published in English language while one article was published in Polish language then translated to English language. DATA SOURCES: All three randomized control trials were found via PubMed OUTCOMES MEASURED: The primary outcomes measured by the patient and investigator was the efficacy of KT in the reduction of pain during a specific post-operative period. Pain was reported by the patient through the Laitinen pain scale and the Lysholm scale. RESULTS: The first study showed statistically relevant differences when compared as intragroup but when compared as intergroups the results were insignificant (Chan MC, Wee JW, Lim MH. Clin J Sport Med. 2017;27(3):260-265. doi: 10.1097/JSM.0000000000000345. doi). The results found by Balki et al were determined to have insignificant differences (Acta Orthop Traumatol Turc. 2016;50(6):628-634. doi: S1017-995X(16)30222-X [pii]) while the last study was found to have significant differences (Boguszewski D, Tomaszewska I, Adamczyk JG, Bialoszewski D. Ortop Traumatol Rehabil.2013;15(5):469-478. doi: 0.5604/15093492.1084361.) CONCLUSIONS: The answer to whether KT is effective in reducing post-operative pain is inconclusive based upon the three selected studies

Numerical Solution of Differential Equations by the Parker-Sochacki Method

A tutorial is presented which demonstrates the theory and usage of the Parker-Sochacki method of numerically solving systems of differential equations. Solutions are demonstrated for the case of projectile motion in air, and for the classical Newtonian N-body problem with mutual gravitational attraction.Comment: Added in July 2010: This tutorial has been posted since 1998 on a university web site, but has now been cited and praised in one or more refereed journals. I am therefore submitting it to the Cornell arXiv so that it may be read in response to its citations. See "Spiking neural network simulation: numerical integration with the Parker-Sochacki method:" J. Comput Neurosci, Robert D. Stewart & Wyeth Bair and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717378

Enhancing Paternal Engagement in a Coparenting Paradigm

Despite the benefits for children and families of fathers who are involved positively with their children, most parenting programs in the United States and globally focus on and collect evaluation data from mothers almost exclusively. Engaging fathers is still viewed as a complex endeavor that is only somewhat successful. In this article, we summarize what is known about engaging fathers in parenting programs, then argue that programs are most effective when coparenting is the focus early in family formation. We rely on two decades of the Supporting Father Involvement program as an example of an initiative that has been effective at recruiting and retaining fathers and mothers in various cultural and national contexts. When programs are inclusive in content and focus on process, are sensitive to differences within and across families, and recognize parents as experts on their children, they are more successful in recruiting and retaining diverse groups of fathers and families

High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs

Targeted endonucleases including zinc finger nucleases (ZFNs) and clustered regularly interspaced short palindromic repeats (CRISPRs)/Cas9 are increasingly being used for genome editing in higher species. We therefore devised a broadly applicable and versatile method for increasing editing efficiencies by these tools. Briefly, 2A peptide-coupled co-expression of fluorescent protein and nuclease was combined with fluorescence-activated cell sorting (FACS) to allow for efficient isolation of cell populations with increasingly higher nuclease expression levels, which translated into increasingly higher genome editing rates. For ZFNs, this approach, combined with delivery of donors as single-stranded oligodeoxynucleotides and nucleases as messenger ribonucleic acid, enabled high knockin efficiencies in demanding applications, including biallelic codon conversion frequencies reaching 30–70% at high transfection efficiencies and ∼2% at low transfection efficiencies, simultaneous homozygous knockin mutation of two genes with ∼1.5% efficiency as well as generation of cell pools with almost complete codon conversion via three consecutive targeting and FACS events. Observed off-target effects were minimal, and when occurring, our data suggest that they may be counteracted by selecting intermediate nuclease levels where off-target mutagenesis is low, but on-target mutagenesis remains relatively high. The method was also applicable to the CRISPR/Cas9 system, including CRISPR/Cas9 mutant nickase pairs, which exhibit low off-target mutagenesis compared to wild-type Cas9

Developmental changes in the organization of functional connections between the basal ganglia and cerebral cortex

The basal ganglia (BG) comprise a set of subcortical nuclei with sensorimotor, cognitive, and limbic subdivisions, indicative of functional organization. BG dysfunction in several developmental disorders suggests the importance of the healthy maturation of these structures. However, few studies have investigated the development of BG functional organization. Using resting-state functional connectivity MRI (rs-fcMRI), we compared human child and adult functional connectivity of the BG with rs-fcMRI-defined cortical systems. Because children move more than adults, customized preprocessing, including volume censoring, was used to minimize motion-induced rsfcMRI artifact. Our results demonstrated functional organization in the adult BG consistent with subdivisions previously identified in anatomical tracing studies. Group comparisons revealed a developmental shift in bilateral posterior putamen/pallidum clusters from preferential connectivity with the somatomotor “face” system in childhood to preferential connectivity with control/attention systems (frontoparietal, ventral attention) in adulthood. This shift was due to a decline in the functional connectivity of these clusters with the somatomotor face system over development, and no change with control/attention systems. Applying multivariate pattern analysis, we were able to reliably classify individuals as children or adults based on BG–cortical system functional connectivity. Interrogation of the features driving this classification revealed, in addition to the somatomotor face system, contributions by the orbitofrontal, auditory, and somatomotor hand systems. These results demonstrate that BG–cortical functional connectivity evolves over development, and may lend insight into developmental disorders that involve BG dysfunction, particularly those involving motor systems (e.g., Tourette syndrome)

Supporting Father Involvement: An Intervention with Community and Child Welfare–Referred Couples

Objective: To expand the evidence base of the Supporting Father Involvement (SFI) intervention to include child welfare families. Background: Taking a preventive father-inclusive approach, SFI aims to strengthen coparenting, parent–child relationships, and child outcomes. This study replicates 4 prior iterations of the program using the same 32-hour curriculum facilitated by clinically trained staff, case managers, and onsite child care and family meals. Method: Participants (N = 239) included low-income (median = $24,000) coparenting pairs, typically mothers and fathers/father figures, half of whom were Mexican American, with toddlers (median age \u3c 3 years). Questionnaires assessing multiple family domains were administered verbally over an 18-month period. Intervention effectiveness was tested through a randomized control trial with immediate treatment or waitlist–control groups using a moderated mediator structural equation model. Results: The model explained 49% to 56% of the variance in children\u27s problem behaviors (intervention and autoregressive effects). The intervention reduced couple conflict, which reduced anxious and harsh parenting, leading to better child outcomes. The intervention was equally effective for community and child welfare–referred families and family dynamics pathways were similar across conditions. Conclusion: With its intentional outreach and inclusion of fathers, SFI offers an effective intervention for lower risk child welfare–involved families. Implications: Results argue for the utility of treating community and child welfare parents in mixed-gender prevention groups that focus on strengthening multiple levels of family relationships

Annual Research Review: interparental conflict and youth psychopathology: an evidence review and practice focused update

The quality of the interparental relationship is recognized as an important influence on child and adolescent psychopathology. Historically, clinically-oriented research on this topic has focused on the impacts of parental divorce and domestic violence as primary interparental relationship influences on child outcomes, to the relative neglect of dimensional or qualitative features of the couple/interparental relationship for youth (child and adolescent) psychopathology. Recent research has highlighted that children are affected by attributes of interparental conflict, specifically how parents express and manage conflicts in their relationship, across a continuum of expressed severity and negativity – ranging from silence to violence. Further, new evidence highlights that children’s emotional, behavioral, social, academic outcomes and future interpersonal relationships are adversely affected by conflict between parents/carers whether adults are living together or not (i.e. married or separated), or where children are or are not genetically related to their rearing parents (e.g. adoption). We review evidence and present an integrated theoretical model, highlighting how children are affected by interparental conflict and what this evidence base means for effective intervention and prevention program development, as well as the development of possible cost-benefit models. Additionally, we review policy implications of this research and highlight some very recent examples of UK-based policy focusing on addressing the interparental relationship and its impact on youth psychopathology

Somatotopic map and inter- and intra-digit distance in Brodmann area 2 by pressure stimulation

The somatotopic representation of the tactile stimulation on the finger in the brain is an essential part of understanding the human somatosensory system as well as rehabilitation and other clinical therapies. Many studies have used vibrotactile stimulations and reported finger somatotopic representations in the Brodmann area 3 (BA 3). On the contrary, few studies investigated finger somatotopic representation using pressure stimulations. Therefore, the present study aimed to find a comprehensive somatotopic representation (somatotopic map and inter- and intra-digit distance) within BA 2 of humans that could describe tactile stimulations on different joints across the fingers by applying pressure stimulation to three joints-the first (p1), second (p2), and third (p3) joints-of four fingers (index, middle, ring, and little finger). Significant differences were observed in the inter-digit distance between the first joints (p1) of the index and little fingers, and between the third joints (p3) of the index and little fingers. In addition, a significant difference was observed in the intra-digit distance between p1 and p3 of the little finger. This study suggests that a somatotopic map and inter- and intra-digit distance could be found in BA 2 in response to pressure stimulation on finger joints.ope