AN UNPUBLISHED COIN OF PONTIUS PILATEAND SOME SPECULATIONS ABOUT HIS CAREER

Some years ago Professor Ursula Vogel's husband was given a coin of Pontius Pilate at a congress in Israel. Although a specimen of a well-known type, it may be of interest to publish it here

Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial

Background: Closed-loop insulin delivery systems have the potential to address suboptimal glucose control in children and adolescents with type 1 diabetes. We compared safety and efficacy of the Cambridge hybrid closed-loop algorithm with usual care over 6 months in this population. Methods: In a multicentre, multinational, parallel randomised controlled trial, participants aged 6–18 years using insulin pump therapy were recruited at seven UK and five US paediatric diabetes centres. Key inclusion criteria were diagnosis of type 1 diabetes for at least 12 months, insulin pump therapy for at least 3 months, and screening HbA1c levels between 53 and 86 mmol/mol (7·0–10·0%). Using block randomisation and central randomisation software, we randomly assigned participants to either closed-loop insulin delivery (closed-loop group) or to usual care with insulin pump therapy (control group) for 6 months. Randomisation was stratified at each centre by local baseline HbA1c. The Cambridge closed-loop algorithm running on a smartphone was used with either (1) a modified Medtronic 640G pump, Medtronic Guardian 3 sensor, and Medtronic prototype phone enclosure (FlorenceM configuration), or (2) a Sooil Dana RS pump and Dexcom G6 sensor (CamAPS FX configuration). The primary endpoint was change in HbA1c at 6 months combining data from both configurations. The primary analysis was done in all randomised patients (intention to treat). Trial registration ClinicalTrials.gov, NCT02925299. Findings: Of 147 people initially screened, 133 participants (mean age 13·0 years [SD 2·8]; 57% female, 43% male) were randomly assigned to either the closed-loop group (n=65) or the control group (n=68). Mean baseline HbA1c was 8·2% (SD 0·7) in the closed-loop group and 8·3% (0·7) in the control group. At 6 months, HbA1c was lower in the closed-loop group than in the control group (between-group difference −3·5 mmol/mol (95% CI −6·5 to −0·5 [–0·32 percentage points, −0·59 to −0·04]; p=0·023). Closed-loop usage was low with FlorenceM due to failing phone enclosures (median 40% [IQR 26–53]), but consistently high with CamAPS FX (93% [88–96]), impacting efficacy. A total of 155 adverse events occurred after randomisation (67 in the closed-loop group, 88 in the control group), including seven severe hypoglycaemia events (four in the closed-loop group, three in the control group), two diabetic ketoacidosis events (both in the closed-loop group), and two non-treatment-related serious adverse events. There were 23 reportable hyperglycaemia events (11 in the closed-loop group, 12 in the control group), which did not meet criteria for diabetic ketoacidosis. Interpretation: The Cambridge hybrid closed-loop algorithm had an acceptable safety profile, and improved glycaemic control in children and adolescents with type 1 diabetes. To ensure optimal efficacy of the closed-loop system, usage needs to be consistently high, as demonstrated with CamAPS FX

On the near wake of a Formula One front wheel

Velocity measurements were made in the near wake of the front wheel of a Formula One car using a laser Doppler anemometer. Tests were carried out on a 50% scale in a closed-return three-quarter open-jet wind tunnel. Three configurations were investigated to determine the effect of both the car and an external wheel support strut on the wheel wake. In each of the configurations the test Reynolds number, based on the wheel diameter, was 6.8 × 105. Three components of the velocity were measured at two planes less than than 1.0D(whereDis the wheel diameter) downstream of the wheel axis. These data were used to visualise the extent of the wake, the flow structures present and also the streamwise turbulence intensity. The presence of the car was found to alter significantly the structure of the wheel wake when compared with an isolated wheel. In addition, the external support strut was found to have less impact in the presence of the car than previous isolated wheel studies have suggested. No previous such studies appear to have been published in the open literature

Planar visualization of vortical flows

This article presents two over-looked post-processing techniques which provide the investigator with additional tools for data analysis and visualization. Both techniques exploit the trend for planar experimental data collection and are implemented in two-dimensions. Critically, both techniques are suitable for use on computational and experimental datasets, require no a-priori knowledge of the flow-field, and minimal user interaction during processing. Firstly, line integral convolution will be introduced as an alternative to streamline or in- plane velocity vector visualization. Secondly, a feature identification procedure will be outlined that can be used to reduce datasets for clearer visualization and provide quantitative information about topological flow features

Laser doppler anemometry measurements in the near-wake of an isolated formula one wheel

An experimental investigation was conducted to identify the main structures in the near wake of an isolated Formula One wheel rotating in ground contact. A 50 percent-scale isolated wheel assembly, geometrically similar to the configuration mounted on a Formula One racing car, was tested in a closed-return three-quarter open-jet wind tunnel. The test Reynolds number, based on wheel diameter was 6.8 × 105. Using laser doppler anemometry, three velocity components were measured with a total of 1966 data points across four planes and within one diameter downstream of the wheel axis. Based on analysis of these data, the main characteristics of the near-wake of an isolated wheel rotating in ground contact are presented. A revised model of the trailing vortex system induced in the wake of such a wheel is proposed, which clarifies the contradictory ones published in the literature to dat