Discovery of a planetary-sized object in the scattered Kuiper belt

We present the discovery and initial physical and dynamical characterization of the object 2003 UB313. The object is sufficiently bright that for all reasonable values of the albedo it is certain to be larger than Pluto. Pre-discovery observations back to 1989 are used to obtain an orbit with extremely small errors. The object is currently at aphelion in what appears to be a typical orbit for a scattered Kuiper belt object except that it is inclined by about 44 degrees from the ecliptic. The presence of such a large object at this extreme inclination suggests that high inclination Kuiper belt objects formed preferentially closer to the sun. Observations from Gemini Observatory show that the infrared spectrum is, like that of Pluto, dominated by the presence of frozen methane, though visible photometry shows that the object is almost neutral in color compared to Pluto's extremely red color. 2003 UB313 is likely to undergo substantial seasonal change over the large range of heliocentric distances that it travels; Pluto at its current distance is likely to prove a useful analog for better understanding the range of seasonal changes on this body.Comment: 9 pages, 1 figur

Phenomenological theory of cuprate superconductivity

Reasonably good agreement with the superconducting transitiontemperatures of the cuprate high‐T c superconductors can be obtained on the basis of an approximate phenomenological theory. In this theory, two criteria are used to calculate the superconducting transitiontemperature. One is that the quantum wavelength is of the order of the electron‐pair spacing. The other is that a fraction of the normal carriers exist as Cooper pairs at T c . The resulting simple equation for T c contains only two parameters: the normal carrier density and effective mass. We calculate specific transition temperatures for 12 cuprate superconductors

Black Hole Radiation and Volume Statistical Entropy

The simplest possible equation for Hawking radiation, and other black hole radiated power is derived in terms of black hole density. Black hole density also leads to the simplest possible model of a gas of elementary constituents confined inside a gravitational bottle of Schwarzchild radius at tremendous pressure, which yields identically the same functional dependence as the traditional black hole entropy. Variations of Sbh can be obtained which depend on the occupancy of phase space cells. A relation is derived between the constituent momenta and the black hole radius which is similar to the Compton wavelength relation.Comment: 11 pages, no figures. Key Words: Black Hole Entropy, Hawking Radiation, Black Hole density. This is a better pdf versio

Earthquake slip surfaces identified by biomarker thermal maturity within the 2011 Tohoku-Oki earthquake fault zone.

Extreme slip at shallow depths on subduction zone faults is a primary contributor to tsunami generation by earthquakes. Improving earthquake and tsunami risk assessment requires understanding the material and structural conditions that favor earthquake propagation to the trench. We use new biomarker thermal maturity indicators to identify seismic faults in drill core recovered from the Japan Trench subduction zone, which hosted 50 m of shallow slip during the Mw9.1 2011 Tohoku-Oki earthquake. Our results show that multiple faults have hosted earthquakes with displacement ≥ 10 m, and each could have hosted many great earthquakes, illustrating an extensive history of great earthquake seismicity that caused large shallow slip. We find that lithologic contrasts in frictional properties do not necessarily determine the likelihood of large shallow slip or seismic hazard

Economics of zoonoses surveillance in a ‘One Health’ context: an assessment of Campylobacter surveillance in Switzerland

Cross-sectorial surveillance and general collaboration between the animal and the public health sectors are increasingly recognized as needed to better manage the impacts of zoonoses. From 2009, the Swiss established a Campylobacter mitigation system that includes human and poultry surveillance data-sharing within a multi-sectorial platform, in a ‘One Health’ approach. The objective of this study was to explore the economics of this cross-sectorial approach, including surveillance and triggered interventions. Costs and benefits of the One Health and of the uni-sectorial approach to Campylobacter surveillance were identified using an economic assessment framework developed earlier. Cost information of surveillance activities and interventions was gathered and disability-adjusted life years (DALYs) associated with the disease estimated for 2008 and 2013. In the first 5 years of this One Health approach to Campylobacter mitigation, surveillance contributed with information mainly used to perform risk assessments, monitor trends and shape research efforts on Campylobacter. There was an increase in costs associated with the mitigation activities following integration, due mainly to the allocation of additional resources to research and implementation of poultry surveillance. The overall burden of campylobacteriosis increased by 3·4–8·8% to 1751–2852 DALYs in 2013. In the timing of the analysis, added value associated with this cross-sectorial approach to surveillance of Campylobacter in the country was likely generated through non-measurable benefits such as intellectual capital and social capital

Photometric Light Curve for the Kuiper Belt Object 2000 EB173 on 78 Nights

Kuiper Belt Objects (KBOs) are generally very faint and cannot in practice be monitored with a well-sampled long-term light curve; so our discovery of the bright KBO 2000 EB173 offers an excellent opportunity for synoptic studies. We present a well-sampled photometric time series (77 R magnitudes and 29 V magnitudes on 78 nights) over a 225-day time span centered on the 2001 opposition. The light curve (corrected to the year 2001 opposition distance) varies from 19.11 to 19.39 mag with a single peak that is smooth, time symmetric, and coincident with opposition. All variations in the light curve are consistent with a linear opposition surge (Ropp = 19.083 + 0.125Xalpha, where alpha is the solar phase angle), while any rotational modulation must have a peak-to-peak amplitude of less than 0.097 mag. This is the first measured opposition surge for any KBO (other than Pluto). The V-R color is 0.63+-0.02, with no apparent variation with phase at the few percent level. With R=19.11 at opposition, 2000 EB173 remains the brightest known KBO and a prime target for future photometric and spectroscopic studies

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate

Background Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly derived from glucose. In hypoxia, however, flux from glucose to acetyl-CoA decreases, and the fractional contribution of glutamine to acetyl-CoA increases. The significance of other acetyl-CoA sources, however, has not been rigorously evaluated. Here we investigate quantitatively, using 13C-tracers and mass spectrometry, the sources of acetyl-CoA in hypoxia.<p></p> Results In normoxic conditions, cultured cells produced more than 90% of acetyl-CoA from glucose and glutamine-derived carbon. In hypoxic cells, this contribution dropped, ranging across cell lines from 50% to 80%. Thus, under hypoxia, one or more additional substrates significantly contribute to acetyl-CoA production. 13C-tracer experiments revealed that neither amino acids nor fatty acids are the primary source of this acetyl-CoA. Instead, the main additional source is acetate. A large contribution from acetate occurs despite it being present in the medium at a low concentration (50–500 μM).<p></p> Conclusions Acetate is an important source of acetyl-CoA in hypoxia. Inhibition of acetate metabolism may impair tumor growth.<p></p&gt