Risk of prostate cancer after isolated high-grade prostatic intraepithelial neoplasia (HGPIN) detected on extended core needle biopsy : a UK hospital experience.

Background High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor lesion to prostate cancer (CaP). UK-based studies examining the occurrence of isolated HGPIN and subsequent risk of CaP are lacking. Our aim was to assess the occurrence of HGPIN in a regional UK population and to determine whether in a retrievable cohort of such patients that had repeat extended core biopsies, there was an elevated risk of CaP. Methods A retrospective analysis of the pathology database was conducted at our institution (Lancashire Teaching Hospitals NHS Foundation Trust) for prostate biopsies recorded between January 2001 and December 2005 (all extended core biopsies). Those patients with isolated HGPIN on 1st set of biopsies were identified and, their clinical characteristics and pathological findings from subsequent biopsies (if any) were determined. The risk of CaP on subsequent biopsies based on presenting baseline PSA was stratified. Results Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 CaP diagnoses were made. Age at first biopsy (P 20 ng/ml – 87.5%. Conclusion Based on our results, we recommend delaying the 1st repeat biopsy at low PSA range but to have a shorter interval to repeat biopsies at intermediate and higher PSA ranges

Fuel Cell Fed BLDC Motor Drive

Fuel cell provides ultra clean, high efficient electric energy rather than other energy resources. It is suitable for hybrid electric vehicle application since it does not emit any pollutant. Hence the fuel cell is used as source in this paper. A non isolated resonant PWM ZVZCS high step up DC-DC converter is used to boost the voltage level obtained from the full cell. This converter reduces the switching loss, eliminates the diode reverse recovery problem thereby increases the step up ratio and efficiency. The boosted voltage is given to the three phase inverter circuit to supply the stator current of BLDC motor. This model is simulated using MATLAB software and performance parameters were analyzed. Keywords - Resonant PWM, ZVZCS, high step up, step up rati

Video frame data conversion of the RGB feature sequence

Query Video has been send from base station to relay station. Base station sending video signal. And then user extract the video.Thus the video has been convert into several frame. Thus the video frame is covert into data conversion. Finally synchronization of the video frame.Hash code will be generation. This code can be used to the video secured purpose. Rijndael algorithm can be used to the formation of frame. Thus the encrypted conversion has been send from base station to relay station. Finally finding the RGB color.View conversion can be used to read the video data file. Calculate the time stamp, sequence,data length,and calculate the frame of the dimension(Width,Height). The proposed DTW-based synchronization method can achieve automatic synchronization for not only FH vectors, but also other types of video hashing methods. Shows the benefits of the proposed synchronization method to hash code generation. Again, the detection performance is significantly improved comparing with random recuperation

Elastic and Raman scattering of 9.0 and 11.4 MeV photons from Au, Dy and In

Monoenergetic photons between 8.8 and 11.4 MeV were scattered elastically and in elastically (Raman) from natural targets of Au, Dy and In.15 new cross sections were measured. Evidence is presented for a slight deformation in the 197Au nucleus, generally believed to be spherical. It is predicted, on the basis of these measurements, that the Giant Dipole Resonance of Dy is very similar to that of 160Gd. A narrow isolated resonance at 9.0 MeV is observed in In.Comment: 31 pages, 11 figure

SYNTHESIS, CHARACTERISATION AND APPLICATION OF PHENOL-FORMALDEHYDE RESIN BLENDED WITH SULPHONATED PHYLLANTHUS EMBLICA, LINN., CARBON

Phenol – Formaldehyde Resin (PFR) is blended with Sulphonated Phyllanthus emblica, Linn., Carbon (SPEC) in various proportions by weight percentage (0-50%w/w). A few composite cation-exchangers were prepared by varying the amount of SPEC (a source of cheap and renevable plant material) in the blends from 10 to 50% (w/w). Reaction conditions for the preparation of blends were optimised. IR spectra, TGA traces, and SEM photos were taken for the characterization of  resins. Physico-chemical, properties of the composite resins have been determined. The composites are insoluble in various solvents and reagents and stable towards heat.   Cation exchange capacity (CEC) of the composite resins, decreased with the increasing percentage of SPEC in the blend. Thermodynamic equilibrium constants (lnK) are calculated for H+ - Zn2+ exchanges on the resins having a different amount of SPEC. Thermodynamic parameters are also calculated and suitable explanations are given. The composites up to 20% (w/w) blending retains all the essential properties of the original PFR, since the Phyllanthus emblica, Linn., is the low cost, freely available plant material. Therefore, the composites could be used as low cost ion-exchangers, when SPEC partly replaces the original PFR up to 20% (w/w) blending without affecting the properties of PFR

"We live from mother nature":neoliberal globalization, commodification, the 'war on drugs', and biodiversity in Colombia since the 1990s

This article explores how macroeconomic and environmental policies instituted since the 1990s have altered meanings, imaginaries, and the human relationship to nature in Colombia. The Colombian nation-state is pluri-ethnic, multilingual, and megabiodiverse. In this context, indigenous peoples, Afro-Colombians, and some peasant communities survive hybridization of their cultures. They have developed their own ways of seeing, understanding, and empowering the world over centuries of European rule. However, threats to relatively discrete cultural meanings have increased since major changes in the 1990s, when Colombia experienced the emergence of new and modern interpretations of nature, such as “biodiversity,” and a deepening of globalized neoliberal economic and political management. These policies involve a modern logic of being in the world, the establishment of particular regulatory functions for economies, societies, and the environment, and their spread has been facilitated by webs of political and economic power. We trace their local effects with reference to three indigenous groups

Culturally Sensitive Interventions in Pediatric Primary Care Settings: A Systematic Review.

CONTEXT: Culturally sensitive interventions in the pediatric primary care setting may help reduce health disparities. Less is known on the development of these interventions, their target groups, and their feasibility, acceptability, and impact on health outcomes. OBJECTIVE: We conducted a systematic review to describe culturally sensitive interventions developed for the pediatric primary care setting. DATA SOURCES: PubMed, Web of Science, Cumulative Index to Nursing and Allied Health Literature, and PsycInfo (January 2000 to July 2020). STUDY SELECTION: Studies were eligible for inclusion if they were (1) original research on an intervention with an evaluation, (2) within a pediatric primary care setting, (3) not limited to education for providers, (4) not limited to interpreter use, and (5) based in the United States. DATA EXTRACTION: The following were extracted: study topic, study design, intervention, cultural sensitivity strategies and terminology, setting, target group, sample size, feasibility, acceptability, and health outcomes. RESULTS: Twenty-five studies described 23 interventions targeting a variety of health topics. Multiple cultural sensitivity strategies were used, most commonly sociocultural (83%). Most interventions (57%) were focused on Hispanic/Latino families. Interventions were generally reported as being feasible and acceptable; some also changed health outcomes. LIMITATIONS: Small samples and heterogenous methods subject to bias were used. Relevant articles may have been missed because of the variety of terms used to describe cultural sensitivity. CONCLUSIONS: The included articles provide preliminary evidence that culturally sensitive interventions can be feasible and effective and may help eliminate disparities for patients from communities with barriers to equitable care

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

The Jacobi Factoring Circuit: Quantum Factoring with Near-Linear Gates and Sublinear Space and Depth

We present a compact quantum circuit for factoring a large class of integers, including some whose classical hardness is expected to be equivalent to RSA (but not including RSA integers themselves). To our knowledge, it is the first polynomial-time circuit to achieve sublinear qubit count for a classically-hard factoring problem; the circuit also achieves sublinear depth and nearly linear gate count. We build on the quantum algorithm for squarefree decomposition discovered by Li, Peng, Du and Suter (Nature Scientific Reports 2012), which relies on computing the Jacobi symbol in quantum superposition. Our circuit completely factors any number $N$, whose prime decomposition has distinct exponents, and finds at least one non-trivial factor if not all exponents are the same. In particular, to factor an $n$-bit integer $N=P^2 Q$ (with $P$ and $Q$ prime, and $Q<2^m$ for some $m$), our circuit uses $\widetilde{O}(m)$ qubits and has depth at most $\widetilde{O}(m + n/m)$, with $\widetilde{O}(n)$ quantum gates. When $m=\Theta(n^a)$ with $2/3 < a < 1$, the space and depth are sublinear in $n$, yet no known classical algorithms exploit the relatively small size of $Q$ to run faster than general-purpose factoring algorithms. We thus believe that factoring such numbers has potential to be the most concretely efficient classically-verifiable proof of quantumness currently known. The technical core of our contribution is a new space-efficient quantum algorithm to compute the Jacobi symbol of $A$ mod $B$, in the regime where $B$ is classical and much larger than $A$. Crucially, our circuit reads the bits of the classical value $B$ in a streaming fashion, never storing more than $\widetilde{O}(\log A)$ qubits of quantum information at one time. In the context of the larger Jacobi algorithm for factoring $N = P^2Q$, this reduces the overall qubit count to be roughly proportional to the length of $Q$, rather than the length of $N$. Our circuit for computing the Jacobi symbol is also highly gate-efficient and parallelizable, achieving gate count $\widetilde{O}(\log B)$ and depth at most $\widetilde{O}(\log A + \log B/\log A)$. Finally, we note that our circuit for computing the Jacobi symbol generalizes to related problems, such as computing the greatest common divisor, and thus could be of independent interest

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication