Ambulatory Care Pharmacy Resident

Objectives: 1. Review the background, epidemiology, and diagnostic criteria for the antiphospholipid syndrome 2. List clinical manifestations associated with antiphospholipid syndrome 3. Describe the pathophysiology of thrombosis in the antiphospholipid syndrome 4. Evaluate the evidence for the different intensities of oral anticoagulation in the 1. Background 1-3 i. Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL)

A computational group theoretic symmetry reduction package for the SPIN model checker

Symmetry reduced model checking is hindered by two problems: how to identify state space symmetry when systems are not fully symmetric, and how to determine equivalence of states during search. We present TopSpin, a fully automatic symmetry reduction package for the Spin model checker. TopSpin uses the Gap computational algebra system to effectively detect state space symmetry from the associated Promela specification, and to choose an efficient symmetry reduction strategy by classifying automorphism groups as a disjoint/wreath product of subgroups. We present encouraging experimental results for a variety of Promela examples

“Ain’t Nuthin Wrong with Being a Trojan Man”: Discourse on Safe-Sex in Rap Music, 1985-1995

This essay methodically tracks references to safe-sex in rap music and analyzes their implications. Reviewing over 3,000 songs from 1985 to 1995, the authors found that the tone and messages of these references differed substantially. While many artists celebrated risky and indiscriminate sexual behavior– their work marred by a misogny and homophobia that often stigmatized persons living with sexually transmitted diseases (STDs)– many other artists portrayed safe-sex in a positive light, either as a responsible approach to sexual behavior, or as a pragmatic tool of urban survival. These songs normalized the use of condoms, and educated listeners by raising awareness about STDs and encouraging positive sexual-health practices. Some artists offered an expanded commentary, critical of the government’s inadequate response to the HIV/AIDS crisis in the African-American community. The essay contends that during the time period under examination, rap music was an invaluable source of information about safe-sex and sexual health practices fot a segment of the population that traditional educational forums had trouble reaching or establishing credibility among. That by 1992 mainstream media outlets were utilizing rap artists to reach and educate a younger, more extensive audience supports the conclusion that this type of messaging was understood as effective

Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics

Background In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts (WI-38 human diploid fibroblasts) is considered as logistic only. Results We demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy. Conclusions These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy

atToc159 is a selective transit peptide receptor for the import of nucleus-encoded chloroplast proteins

The members of the Toc159 family of GTPases act as the primary receptors for the import of nucleus-encoded preproteins into plastids. Toc159, the most abundant member of this family in chloroplasts, is required for chloroplast biogenesis (Bauer, J., K. Chen, A. Hiltbunner, E. Wehrli, M. Eugster, D. Schnell, and F. Kessler. 2000. Nature. 403:203–207) and has been shown to covalently cross-link to bound preproteins at the chloroplast surface (Ma, Y., A. Kouranov, S. LaSala, and D.J. Schnell. 1996. J. Cell Biol. 134:1–13; Perry, S.E., and K. Keegstra. 1994. Plant Cell. 6:93–105). These reports led to the hypothesis that Toc159 functions as a selective import receptor for preproteins that are required for chloroplast development. In this report, we provide evidence that Toc159 is required for the import of several highly expressed photosynthetic preproteins in vivo. Furthermore, we demonstrate that the cytoplasmic and recombinant forms of soluble Toc159 bind directly and selectively to the transit peptides of these representative photosynthetic preproteins, but not representative constitutively expressed plastid preproteins. These data support the function of Toc159 as a selective import receptor for the targeting of a set of preproteins required for chloroplast biogenesis

African tropical rainforest net carbon dioxide fluxes in the twentieth century

The African humid tropical biome constitutes the second largest rainforest region, significantly impacts global carbon cycling and climate, and has undergone major changes in functioning owing to climate and land-use change over the past century. We assess changes and trends in CO2 fluxes from 1901 to 2010 using nine land surface models forced with common driving data, and depict the inter-model variability as the uncertainty in fluxes. The biome is estimated to be a natural (no disturbance) net carbon sink (−0.02 kg C m−2 yr−1 or −0.04 Pg C yr−1, p < 0.05) with increasing strength fourfold in the second half of the century. The models were in close agreement on net CO2 flux at the beginning of the century (σ1901 = 0.02 kg C m−2 yr−1), but diverged exponentially throughout the century (σ2010 = 0.03 kg C m−2 yr−1). The increasing uncertainty is due to differences in sensitivity to increasing atmospheric CO2, but not increasing water stress, despite a decrease in precipitation and increase in air temperature. However, the largest uncertainties were associated with the most extreme drought events of the century. These results highlight the need to constrain modelled CO2 fluxes with increasing atmospheric CO2 concentrations and extreme climatic events, as the uncertainties will only amplify in the next century

Intraoperative detection of insufficient surgical margins in head and neck cancer resection using dual aperture fluorescence ratio imaging

Please click Additional Files below to see the full abstract

Laser photosensitization and metabolic inhibition of tissue culture cells treated with quinacrine hydrochloride

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32698/1/0000065.pd