How young people from culturally and linguistically diverse backgrounds experience mental health: some insights for mental health nurses

This article reports on a part of a study which looked at the mental health of culturally and linguistically diverse (CALD) young people. The research sought to learn from CALD young people, carers, and service providers experiences relevant to the mental health of this group of young people. The ultimate goal was to gain insights that would inform government policy, service providers, ethnic communities and most importantly the young people themselves. To this end, qualitative interviews were undertaken with 123 CALD young people, 41 carers and 14 mental health service providers in Queensland, Western Australia and South Australia. Only one aspect of the study will be dealt with here, namely the views of the young CALD participants, which included risk factors, coping strategies and recommendations about how they could be supported in their struggle to maintain mental health. One of the most important findings of the study relates to the resilience of these young people and an insight into the strategies that they used to cope. The efforts of these young people to assist us in our attempts to understand their situation deserve to be rewarded by improvements in the care that we provide. To this end this article sets out to inform mental health nurses of the results of the study so that they will be in a position to better understand the needs and strengths of their CALD clients and be in a better position to work effectively with them

BMJ Open

ObjectivesThe raising unit price of cigarette has been shown to be one of the most effective ways of reducing cigarette consumption and increasing rates of successful quitting. However, researchers have shown that price-sensitive smokers have used a variety of strategies to mitigate the effect of the rising price of cigarettes on their smoking habits. In particular, 23\ue2\u20ac\u201c34% of adult smokers in the US use cheaper brands, and 18\ue2\u20ac\u201c55% use coupons or promotions. Little is known about the discount use by type of brands. As such, the main purpose of this analysis is to evaluate the uses and price discount effects of these price-related discounts by manufacturers and major brands.SettingAn analysis based on the cross-sectional 2009\ue2\u20ac\u201c2010 National Adult Tobacco Survey (NATS).Participants11\ue2\u20ac\u2026766 current smokers aged 18 or above in the USA.Primary outcome measuresPrice-related discount was defined as smokers who used coupons, rebates, buy-one-get-one-free, two-for-one or any other special promotions for their last cigarettes purchase.ResultsThe use of price-related discounts and associated price impact vary widely by cigarette manufacturer and brand. Approximately one of three Camel, one of four Marlboro and one of eight Newport smokers used price-related discounts on their latest cigarette purchases. The average price reductions of discounts offered by Philip Morris (PM) or R.J. Reynolds (RJR) were around 29 cents per pack while that of Lorillard (Newport only) was 24 cents per pack. Cigarette brands that provided significant per pack price reductions include: PM Marlboro (28 cents), RJR brand Camel (41 cents), Doral (50 cents), Kool (73 cents) and Salem (80 cents), and Lorillard Newport (24 cents).ConclusionsPolicies that decrease price-minimisation strategies will benefit public health

Chemotherapy of Skull Base Chordoma Tailored on Responsiveness of Patient-Derived Tumor Cells to Rapamycin1,2

Skull base chordomas are challenging tumors due to their deep surgical location and resistance to conventional radiotherapy. Chemotherapy plays a marginal role in the treatment of chordoma resulting from lack of preclinical models due to the difficulty in establishing tumor cell lines and valuable in vivo models. Here, we established a cell line from a recurrent clival chordoma. Cells were cultured for more than 30 passages and the expression of the chordoma cell marker brachyury was monitored using both immunohistochemistry and Western blot. Sensitivity of chordoma cells to the inhibition of specific signaling pathways was assessed through testing of a commercially available small molecule kinase inhibitor library. In vivo tumorigenicity was evaluated by grafting chordoma cells onto immunocompromised mice and established tumor xenografts were treated with rapamycin. Rapamycin was administered to the donor patient and its efficacy was assessed on follow-up neuroimaging. Chordoma cells main- tained brachyury expression at late passages and generated xenografts closely mimicking the histology and phe- notype of the parental tumor. Rapamycin was identified as an inhibitor of chordoma cell proliferation. Molecular analyses on tumor cells showed activation of the mammalian target of rapamycin signaling pathway and mutation of KRAS gene. Rapamycin was also effective in reducing the growth of chordoma xenografts. On the basis of these results, our patient received rapamycin therapy with about six-fold reduction of the tumor growth rate upon 10-month follow-up neuroimaging. This is the first case of chordoma in whom chemotherapy was tailored on the basis of the sensitivity of patient-derived tumor cells

Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression

MicroRNAs (miRNAs) from the gene cluster miR-143–145 are diminished in cells of colorectal tumor origin when compared with normal colon epithelia. Until now, no report has addressed the coordinate action of these miRNAs in colorectal cancer (CRC). In this study, we performed a comprehensive molecular and functional analysis of the miRNA cluster regulatory network. First, we evaluated proliferation, migration, anchorage-independent growth and chemoresistance in the colon tumor cell lines after miR-143 and miR-145 restoration. Then, we assessed the contribution of single genes targeted by miR-143 and miR-145 by reinforcing their expression and checking functional recovery. Restoring miR-143 and miR-145 in colon cancer cells decreases proliferation, migration and chemoresistance. We identified cluster of differentiation 44 (CD44), Kruppel-like factor 5 (KLF5), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) as proteins targeted by miR-143 and miR- 145. Their re-expression can partially revert a decrease in transformation properties caused by the overexpression of miR-143 and miR- 145. In addition, we determined a set of mRNAs that are diminished after reinforcing miR-143 and miR-145 expression. The whole transcriptome analysis ascertained that downregulated transcripts are enriched in predicted target genes in a statistically significant manner. A number of additional genes, whose expression decreases as a direct or indirect consequence of miR-143 and miR-145, reveals a complex regulatory network that affects cell signaling pathways involved in transformation. In conclusion, we identified a coordinated program of gene repression by miR-143 and miR-145, in CRC, where either of the two miRNAs share a target transcript, or where the target transcripts share a common signaling pathway. Major mediators of the oncosuppression by miR-143 and miR-145 are genes belonging to the growth factor receptor–mitogen-activated protein kinase network and to the p53 signaling pathwa

The study protocol of a cluster-randomised controlled trial of family-mediated personalised activities for nursing home residents with dementia

<p>Abstract</p> <p>Background</p> <p>Following admission to a nursing home, the feelings of depression and burden that family carers may experience do not necessarily diminish. Additionally, they may experience feelings of guilt and grief for the loss of a previously close relationship. At the same time, individuals with dementia may develop symptoms of depression and agitation (BPSD) that may be related to changes in family relationships, social interaction and stimulation. Until now, interventions to alleviate carer stress and BPSD have treated carers and relatives separately rather than focusing on maintaining or enhancing their relationships. One-to-one structured activities have been shown to reduce BPSD and also improve the caring experience, but barriers such as a lack of resources impede the implementation of activities in aged care facilities. The current study will investigate the effect of individualised activities based on the Montessori methodology administered by family carers in residential care.</p> <p>Methods/Design</p> <p>We will conduct a cluster-randomised trial to train family carers in conducting personalised one-to-one activities based on the Montessori methodology with their relatives. Montessori activities derive from the principles espoused by Maria Montessori and subsequent educational theorists to promote engagement in learning, namely task breakdown, guided repetition, progression in difficulty from simple to complex, and the careful matching of demands to levels of competence. Persons with dementia living in aged care facilities and frequently visiting family carers will be included in the study. Consented, willing participants will be randomly assigned by facility to a treatment condition using the Montessori approach or a control waiting list condition. We hypothesise that family carers conducting Montessori-based activities will experience improvements in quality of visits and overall relationship with the resident as well as higher self-rated mastery, fewer depressive symptoms, and a better quality of life than carers in the waiting list condition.</p> <p>Discussion</p> <p>We hypothesise that training family carers to deliver personalised activities to their relatives in a residential setting will make visits more satisfying and may consequently improve the quality of life for carers and their relatives. These beneficial effects might also reduce nursing staff burden and thus impact positively on residential facilities.</p> <p>Trial Registration</p> <p>Australian New Zealand Clinical Trials Registry - <a href="http://www.anzctr.org.au/ACTRN12611000998943.aspx">ACTRN12611000998943</a></p

Stratigraphy, geochronology and evolution of the Mt. Melbourne volcanic field (North Victoria Land, Antarctica)

Mt. Melbourne (2,732 ma.s.l.) is a large quiescent stratovolcano located in Northern Victoria Land (Antarctica) and is one of a handful of volcanoes on the Antarctic plate with the potential for large-scale explosive eruptions. During the XVIII Italian Expedition in 2002– 2003, the Mt. Melbourne volcanic succession was studied in terms of stratigraphy and sampled for 40Ar/39Ar age determinations and geochemistry. The early, Lower Pleistocene, volcanism was largely alkali basaltic to hawaiitic in composition and monogenetic in style, producing tens of small scoria cones and lava flows scattered over a wide area across the Transantarctic Mountains (Random Hills Period). During the Middle Pleistocene, volcanic activity focused to the area of the Mt. Melbourne stratovolcano, where several monogenetic centres show the transition from early subglacial/ subaqueous conditions to emergent subaerial conditions (Shield Nunatak Period). The oldest exposed deposit associated with the early activity of the Mt. Melbourne stratovolcano (Mt. Melbourne Period) is a trachytic subaerial ignimbrite dated at 123.6±6.0 ka, which reflects the establishment of a crustal magma chamber. Above the ignimbrite a succession of alkali basaltic, hawaiitic, and subordinate benmoreitic lavas and scoria cones is exposed, dated at 90.7±19.0 ka. The Holocene deposits are exposed at the top of Mt. Melbourne, where the crater rim is composed of trachytic to rhyolitic pumice fall deposits, which are also extensively dispersed around the volcano, likely originated from Plinian-scale eruptions. The most recent explosive deposit proved difficult to date accurately because very low quantities of radiogenic 40Ar were released, resulting in imprecise plateau ages of 50±70 and 35±22 ka

Stratigraphy, geochronology and evolution of the Mt. Melbourne volcanic field (North Victoria Land, Antarctica)

Mt. Melbourne (2,732 m a.s.l.) is a large quiescent stratovolcano located in Northern Victoria Land (Antarctica) and is one of a handful of volcanoes on the Antarctic plate with the potential for large-scale explosive eruptions. During the XVIII Italian Expedition in 2002-2003, the Mt. Melbourne volcanic succession was studied in terms of stratigraphy and sampled for Ar-40/Ar-39 age determinations and geochemistry. The early, Lower Pleistocene, volcanism was largely alkali basaltic to hawaiitic in composition and monogenetic in style, producing tens of small scoria cones and lava flows scattered over a wide area across the Transantarctic Mountains (Random Hills Period). During the Middle Pleistocene, volcanic activity focused to the area of the Mt. Melbourne stratovolcano, where several monogenetic centres show the transition from early sub-glacial/subaqueous conditions to emergent subaerial conditions (Shield Nunatak Period). The oldest exposed deposit associated with the early activity of the Mt. Melbourne stratovolcano (Mt. Melbourne Period) is a trachytic subaerial ignimbrite dated at 123.6 +/- 6.0 ka, which reflects the establishment of a crustal magma chamber. Above the ignimbrite a succession of alkali basaltic, hawaiitic, and subordinate benmoreitic lavas and scoria cones is exposed, dated at 90.7 +/- 19.0 ka. The Holocene deposits are exposed at the top of Mt. Melbourne, where the crater rim is composed of trachytic to rhyolitic pumice fall deposits, which are also extensively dispersed around the volcano, likely originated from Plinian-scale eruptions. The most recent explosive deposit proved difficult to date accurately because very low quantities of radiogenic Ar-40 were released, resulting in imprecise plateau ages of 50 +/- 70 and 35 +/- 22 ka