The Sensitivity of First Generation Epoch of Reionization Observatories and Their Potential for Differentiating Theoretical Power Spectra

Statistical observations of the epoch of reionization (EOR) power spectrum provide a rich data set for understanding the transition from the cosmic "dark ages" to the ionized universe we see today. EOR observations have become an active area of experimental cosmology, and three first generation observatories--MWA, PAST, and LOFAR--are currently under development. In this paper we provide the first quantitative calculation of the three dimensional power spectrum sensitivity, incorporating the design parameters of a planned array. This calculation is then used to explore the constraints these first generation observations can place on the EOR power spectrum. The results demonstrate the potential of upcoming power spectrum observations to constrain theories of structure formation and reionization.Comment: 7 pages with 5 figures. Submitted to Ap

S-PRAC: Fast Partial Packet Recovery with Network Coding in Very Noisy Wireless Channels

Well-known error detection and correction solutions in wireless communications are slow or incur high transmission overhead. Recently, notable solutions like PRAC and DAPRAC, implementing partial packet recovery with network coding, could address these problems. However, they perform slowly when there are many errors. We propose S-PRAC, a fast scheme for partial packet recovery, particularly designed for very noisy wireless channels. S-PRAC improves on DAPRAC. It divides each packet into segments consisting of a fixed number of small RLNC encoded symbols and then attaches a CRC code to each segment and one to each coded packet. Extensive simulations show that S-PRAC can detect and correct errors quickly. It also outperforms DAPRAC significantly when the number of errors is high

Electroweak Phase Transition in the U(1)' MSSM

In this work, we have investigated the nature of the electroweak phase transition in the U(1) extended minimal supersymmetric standard model without introducing any exotic fields. The effective potential has been estimated exactly at finite temperature taking into account the whole particle spectrum. For reasonable values of the lightest Higgs and neutralino, we found that the electroweak phase transition could be strongly first order due to: (1) the interactions of the singlet with the doublets in the effective potential, and (2) the evolution of the wrong vacuum that delays the transition.Comment: substantial changes, references added, 18 pages, 4 figure

Lessons from LIMK1 enzymology and their impact on inhibitor design

LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis. Herein, we use X-ray crystallography and activity assays to describe how LIMK1 accomplishes substrate specificity, to suggest a unique ‘rock-and-poke’ mechanism of catalysis and to explore the regulation of the kinase by activation loop phosphorylation. Based on these findings, a differential scanning fluorimetry assay and a RapidFire mass spectrometry activity assay were established, leading to the discovery and confirmation of a set of small-molecule LIMK1 inhibitors. Interestingly, several of the inhibitors were inactive towards the closely related isoform LIMK2. Finally, crystal structures of the LIMK1 kinase domain in complex with inhibitors (PF-477736 and staurosporine, respectively) are presented, providing insights into LIMK1 plasticity upon inhibitor binding

Rapid generation of angular momentum in bounded magnetized plasma

Direct numerical simulations of two-dimensional decaying MHD turbulence in bounded domains show the rapid generation of angular momentum in nonaxisymmetric geometries. It is found that magnetic fluctuations enhance this mechanism. On a larger time scale, the generation of a magnetic angular momentum, or angular field, is observed. For axisymmetric geometries, the generation of angular momentum is absent; nevertheless, a weak magnetic field can be observed. The derived evolution equations for both the angular momentum and angular field yield possible explanations for the observed behavior

A deep level set method for image segmentation

This paper proposes a novel image segmentation approachthat integrates fully convolutional networks (FCNs) with a level setmodel. Compared with a FCN, the integrated method can incorporatesmoothing and prior information to achieve an accurate segmentation.Furthermore, different than using the level set model as a post-processingtool, we integrate it into the training phase to fine-tune the FCN. Thisallows the use of unlabeled data during training in a semi-supervisedsetting. Using two types of medical imaging data (liver CT and left ven-tricle MRI data), we show that the integrated method achieves goodperformance even when little training data is available, outperformingthe FCN or the level set model alone

Spectral and localization properties of the Dirichlet wave guide with two concentric Neumann discs

Bound states of the Hamiltonian describing a quantum particle living on three dimensional straight strip of width $d$ are investigated. We impose the Neumann boundary condition on the two concentric windows of the radii $a$ and $b$ located on the opposite walls and the Dirichlet boundary condition on the remaining part of the boundary of the strip. We prove that such a system exhibits discrete eigenvalues below the essential spectrum for any $a,b>0$. When $a$ and $b$ tend to the infinity, the asymptotic of the eigenvalue is derived. A comparative analysis with the one-window case reveals that due to the additional possibility of the regulating energy spectrum the anticrossing structure builds up as a function of the inner radius with its sharpness increasing for the larger outer radius. Mathematical and physical interpretation of the obtained results is presented; namely, it is derived that the anticrossings are accompanied by the drastic changes of the wave function localization. Parallels are drawn to the other structures exhibiting similar phenomena; in particular, it is proved that, contrary to the two-dimensional geometry, at the critical Neumann radii true bound states exist.Comment: 25 pages, 7 figure

Pulsatile blood flow through a constricted porous artery

In this paper a speculative study of an incompressible Newtonian blood flow through a constricted porous channel and pulsatile nature is inspected. Porosity parameter λ is incorporated in the momentum equation. Governing nonlinear differential equations are numerically evaluated by employing the perturbation method technique for a very small perturbation parameter ε 1 such that ε ≠ 0 and with conformable boundary conditions. Numerical results of the flow velocity profile and volumetric flow rate have been derived numerically and detailed graphical analysis for different physical parameters porosity, Reynolds number and stenosis has been presented. It is found that arterial blood velocity is dependent upon all of these factors and that the relationship of fluid velocity and flow is more complex and nonlinear than heretofore generally believe. Furthermore the flow velocity enhanced with Reynolds number, porosity parameter and at maximum position of the stenosis/constriction