The effect of lift on the wave-making resistance of multi-hull craft

A potential based panel method is presented to estimate the wave-making characteristics of multi-hull craft. In order to simulate the lifting potential flow around the sub-hulls, the method adopts mixed source/doublet distributions on the sub-hulls and their wake surface, while sources are distributed on the main hull and the free surface. In this way, the asymmetric flow characteristics of the sub-hull are properly simulated, i.e., a Kutta condition is satisfied at the trailing edge of the sub-hull. Comparison is made between the numerical and model experimental measurements, and a good correlation has been found. The wave-making characteristics and pressure distributions on the sub-hull predicted by the present method can differ from those based on a distribution of sources alone, especially the pressure distributions at the stern of the sub-hulls

A seakeeping analysis method for an air-lifted vessel

A seakeeping analysis in the frequency domain is presented to predict the motion response of an airlifted vessel (ALV) in waves. The ALV is supported by pressurised air in two separate cushion chambers; the pressure variation in the cushions has a significant effect on the motions of the vessel. The adiabatic gas law is used to couple cushion pressure and the free-surface elevation of water inside the chamber. Attention is focused on the waves generated by the pressure, and a method is presented to compute the corresponding free-surface elevation. New numerical schemes are proposed for calculating the threedimensional free-surface elevation for the four wave numbers. Numerical results of the free-surface elevation, escape area, escape volume and motion responses of the ALV are provided. & 2008 Elsevier Ltd. All rights reserved

Will I? won't I? Why do men who have sex with men present for post-exposure prophylaxis for sexual exposures?

Background: Failures of post-exposure prophylaxis following sexual exposure (PEPSE) to prevent seroconversion have been reported and are often associated with ongoing risk exposure. Understanding why men who have sex with men (MSM) access PEPSE on some occasions and not others may lead to more effective health promotion and disease prevention strategies Methods: A qualitative study design using semi-structured interviews of 15 MSM within 6 months of them initiating PEPSE treatment at an HIV outpatient service in Brighton, UK. Results: PEPSE seeking was motivated by a number of factors: an episode that related to a particular sexual partner and their behaviour; the characteristics of the venue where the risk occurred; the respondent’s state of mind and influences of alcohol and recreational drug use; and their perceived beliefs on the effectiveness of PEPSE. Help was sought in the light of a “one-off” or “unusual” event. Many respondents felt they were less likely to behave in a risky manner following PEPSE. Conclusion: If PEPSE is to be effective as a public health measure, at risk individuals need to be empowered to make improved risk calculations from an increased perception that they could be exposed to HIV if they continue their current behaviour patterns. The concern is that PEPSE was sought by a low number of MSM implying that a greater number are not using the service based on failure to make accurate risk calculations or recognise high-risk scenario

Reconsidering obstetric death and female fertility in Anglo-Saxon England

Little has been written about female fertility and maternal mortality from an archaeological perspective. Typically debates focus on the physical aspects of childbirth, ignoring an obvious truth: the biggest single cause of death for women was childbirth. Whether death took place as a result of mechanical malpresentation, infection or blood loss, the root cause was undeniable. In this article we argue that post-mortem extrusion is improbable and that young infants and women found buried together are likely to have died together. However, most deaths would not have been simultaneous and so we build on demographic data to conclude that the early Anglo-Saxons engaged institutions which controlled female sexuality. Late marriage, cultural and legal taboos and an emphasis on mature fertility acted to limit the probability of death; however, the risk to the individual was real and each funerary party was the agent that constructed death ways to manage loss

Peer review and citation data in predicting university rankings, a large-scale analysis

Most Performance-based Research Funding Systems (PRFS) draw on peer review and bibliometric indicators, two different method- ologies which are sometimes combined. A common argument against the use of indicators in such research evaluation exercises is their low corre- lation at the article level with peer review judgments. In this study, we analyse 191,000 papers from 154 higher education institutes which were peer reviewed in a national research evaluation exercise. We combine these data with 6.95 million citations to the original papers. We show that when citation-based indicators are applied at the institutional or departmental level, rather than at the level of individual papers, surpris- ingly large correlations with peer review judgments can be observed, up to r <= 0.802, n = 37, p < 0.001 for some disciplines. In our evaluation of ranking prediction performance based on citation data, we show we can reduce the mean rank prediction error by 25% compared to previous work. This suggests that citation-based indicators are sufficiently aligned with peer review results at the institutional level to be used to lessen the overall burden of peer review on national evaluation exercises leading to considerable cost savings

Mission possible: diatoms can be used to infer past duckweed (lemnoid Araceae) dominance in ponds

Compared to larger lakes, ponds have rarely been the focus of palaeoecological studies. A common feature of ponds, especially those subject to eutrophication, is mass surface coverings of lemnoid Araceae (duckweed) which have severe implications for ecological processes in small waterbodies, in particular lowered oxygen content. To help understand the implications of duckweed dominance for the long-term ecology of ponds, and to determine the potential for palaeoecological studies in ponds more generally, we develop a new diatom-based Lemna-indicator metric. Recent studies of diatom host-plant relationships have shown significant associations between duckweed and the epiphytes Lemnicola hungarica and Sellaphora saugerresii (formally known as Sellaphora seminulum). To determine the potential of these species as palaeo-indicators of long-term duckweed dynamics in ponds, we investigated the diatom composition of surface sediment assemblages in sets of duckweed and non-duckweed-dominated ponds in Norfolk, eastern England. In addition, we undertook diatom analysis of two cores from a small farmland pond (Bodham Rail Pit) subject to a known duckweed dominance event (1999–2005). Both L. hungarica and S. saugerresii were significant predictors of past Lemna dominance in the surface sediments. Further, in the core study, both diatom species accurately and closely tracked the documented “on–off” duckweed cycle. Our study suggests huge potential for using ponds in palaeoecological studies and for diatom-based investigations of floating plant histories

Immunopathological aspects of trypanosomal meningoencephalitis in vervet monkeys after relapse following BerenilR treatment

Four quarantined vervet monkeys were treated with intramuscular BerenilR in patent CNS infection after experimental trypanosome inoculation with Trypanosoma brucei rhodesiense or T. brucei brucei. All four animals relapsed in the post-therapeutic survival time of 37 to 209 days when they had fully developed meningoencephalitis in histological sections with the presence of interstitial intracerebral trypanosomes, which were confirmed in two monkeys by electron microscopy. In both, sequential samples of the serum and cerebrospinal fluid were analysed for circulating immune complexes, immunoglobulins and albumin. From these results the intracerebral IgG synthesis and the impairment of the blood-brain-barrier were calculated, both being present in advanced infection. Circulating immune complexes were present in the serum, but could not be demonstrated in the cerebrospinal fluid. The monkey model therefore permits the study of various aspects of cerebral trypanosomiasis. BerenilR treatment is inefficient in patent CNS infection and leads to a protracted, less virulent disease course with terminal meningoencephalitis and intracerebral "persister” trypanosomes. This drug-induced trypanosome shift with meningoencephalitis could be used for chemotherapeutic purposes to test new compounds in late stage diseas

Links between soil microbial communities and plant traits in a species-rich grassland under long-term climate change

Climate change can influence soil microorganisms directly by altering their growth and activity but also indirectly via effects on the vegetation, which modifies the availability of resources. Direct impacts of climate change on soil microorganisms can occur rapidly, whereas indirect effects mediated by shifts in plant community composition are not immediately apparent and likely to increase over time. We used molecular fingerprinting of bacterial and fungal communities in the soil to investigate the effects of 17 years of temperature and rainfall manipulations in a species‐rich grassland near Buxton, UK. We compared shifts in microbial community structure to changes in plant species composition and key plant traits across 78 microsites within plots subjected to winter heating, rainfall supplementation, or summer drought. We observed marked shifts in soil fungal and bacterial community structure in response to chronic summer drought. Importantly, although dominant microbial taxa were largely unaffected by drought, there were substantial changes in the abundances of subordinate fungal and bacterial taxa. In contrast to short‐term studies that report high resistance of soil fungi to drought, we observed substantial losses of fungal taxa in the summer drought treatments. There was moderate concordance between soil microbial communities and plant species composition within microsites. Vector fitting of community‐weighted mean plant traits to ordinations of soil bacterial and fungal communities showed that shifts in soil microbial community structure were related to plant traits representing the quality of resources available to soil microorganisms: the construction cost of leaf material, foliar carbon‐to‐nitrogen ratios, and leaf dry matter content. Thus, our study provides evidence that climate change could affect soil microbial communities indirectly via changes in plant inputs and highlights the importance of considering long‐term climate change effects, especially in nutrient‐poor systems with slow‐growing vegetation

Selecting Potential Pharmacological Interventions in Sarcopenia

Sarcopenia of age is prevalent and costly and proven pharmacological interventions are currently lacking. The pathophysiology of sarcopenia is incompletely understood but appears to involve multiple pathways, including inflammation, hormonal dysregulation, impaired regeneration, mitochondrial dysfunction and denervation. There are several ways in which we might select potential pharmacological interventions for testing in clinical trials. These include a 'bottom-up' approach using basic science to elucidate the molecular processes involved and identify potential targets from this knowledge-a strategy that has led to the development of myostatin inhibitors. A 'top-down' approach might use observational data to examine the association between physical function and use of certain medications, such as the association between angiotensin-converting enzyme inhibitors with slower decline in physical function. Once a pharmacological intervention has been proposed, efficacy must be demonstrated in this complex multi-morbid population. Both muscle mass and muscle function need to be measured as outcomes, but these outcomes require large sample sizes and sufficient follow-up to detect change. Biomarkers that can predict the response of sarcopenia to intervention after a short time would greatly assist our ability to select candidate interventions in short proof-of-concept trials. Further development of trial methods is required to accelerate progress in this important area of medicine for older people.</p

Priorities for International Forest Research

The world is moving towards knowledge-based societies. Economies are globalizing. The global public goods value of forests is being recognised at the same time that the traditional role of state forest agencies in production forestry is being taken over by multi-national corporations. At the same time emerging technologies are greatly enhancing our ability to assess and monitor forest attributes, process and disseminate information, and enhance forest production. All of these changes will have an impact on how forest research is organized, who does it, and who pays for it. It seems inevitable that much traditional forestry research concerned with sustainability and productivity enhancement at the stand level, will be taken over by the private sector. However, there is going to be a major challenge in finding resources for research in support of the public goods values of forests at both the local, national and global levels. There is a widely held view that we are in the midst of a world forest crisis. It is not a crisis of declining production but one of erosion of public goods, environmental values of forests. So far, we have not seen a concerted scientific response to this crisis. The Inter-Governmental Panel on Forests (IPF) has given us the mandate to orchestrate such a response and the World Forestry Congress is a valuable opportunity to provide impetus to a new vision of forest science for the 21st century