Fifty Years Of Disability Law: The Relevance Of The Universal Declaration

This discussion is about the relevance of the Universal Declaration to disability rights law. There has been a good deal of discussion historically about the status of the Declaration

Population Studies of the Unidentified EGRET Sources

The third EGRET catalog contains a large number of unidentified sources. This subset of objects is expected to include known gamma-ray emitters of Galactic origin such as pulsars and supernova remnants, in addition to an extragalactic population of blazars. However, current data allows the intriguing possibility that some of these objects may represent a new class of yet undiscovered gamma-ray sources. Many theoretically motivated candidate emitters (e.g. clumps of annihilating dark matter particles) have been suggested to account for these detections. We take a new approach to determine to what extent this population is Galactic and to investigate the nature of the possible Galactic component. By assuming that galaxies similar to the Milky Way should host comparable populations of objects, we constrain the allowed Galactic abundance and distribution of various classes of gamma-ray sources using the EGRET data set. We find it is highly improbable that a large number of the unidentified sources are members of a Galactic halo population, but that a distribution of the sources entirely in the disk and bulge is plausible. Finally, we discuss the additional constraints and new insights that GLAST will provide.Comment: 6 pages, 2 figures, to appear in proceedings of "The Multi-Messenger Approach to High Energy Gamma-Ray Sources", Barcelona, 4-7 July, 2006; comments welcom

Unresolved Unidentified Source Contribution to the Gamma-ray Background

The large majority of EGRET point sources remain without an identified low-energy counterpart, and a large fraction of these sources are most likely extragalactic. Whatever the nature of the extragalactic EGRET unidentified sources, faint unresolved objects of the same class must have a contribution to the diffuse extragalactic gamma-ray background (EGRB). Understanding this component of the EGRB, along with other guaranteed contributions from known sources, is essential if we are to use this emission to constrain exotic high-energy physics. Here, we follow an empirical approach to estimate whether a potential contribution of unidentified sources to the EGRB is likely to be important, and we find that it is. Additionally, we show how upcoming GLAST observations of EGRET unidentified sources, as well as of their fainter counterparts, can be combined with GLAST observations of the Galactic and extragalactic diffuse backgrounds to shed light on the nature of the EGRET unidentified sources even without any positional association of such sources with low-energy counterparts.Comment: 11 pages, 5 figures, submitted to Ap

Emergence of switch-like behavior in a large family of simple biochemical networks

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing the network topologies that can exhibit bistability remains a challenge, in part due to the exceedingly large variety of GRNs that exist for even a small number of components. We begin to address this problem by employing chemical reaction network theory in a comprehensive in silico survey to determine the capacity for bistability of more than 40,000 simple networks that can be formed by two transcription factor-coding genes and their associated proteins (assuming only the most elementary biochemical processes). We find that there exist reaction rate constants leading to bistability in ~90% of these GRN models, including several circuits that do not contain any of the TF cooperativity commonly associated with bistable systems, and the majority of which could only be identified as bistable through an original subnetwork-based analysis. A topological sorting of the two-gene family of networks based on the presence or absence of biochemical reactions reveals eleven minimal bistable networks (i.e., bistable networks that do not contain within them a smaller bistable subnetwork). The large number of previously unknown bistable network topologies suggests that the capacity for switch-like behavior in GRNs arises with relative ease and is not easily lost through network evolution. To highlight the relevance of the systematic application of CRNT to bistable network identification in real biological systems, we integrated publicly available protein-protein interaction, protein-DNA interaction, and gene expression data from Saccharomyces cerevisiae, and identified several GRNs predicted to behave in a bistable fashion.Comment: accepted to PLoS Computational Biolog

Gamma-ray signatures of annihilation to charged leptons in dark matter substructure

Due to their higher concentrations and small internal velocities, Milky Way subhalos can be at least as important as the smooth halo in accounting for the GeV positron excess via dark matter annihilation. After showing how this can be achieved in various scenarios, including in Sommerfeld models, we demonstrate that, in this case, the diffuse inverse-Compton emission resulting from electrons and positrons produced in substructure leads to a nearly-isotropic signal close to the level of the isotropic GeV gamma-ray background seen by Fermi. Moreover, we show that HESS cosmic-ray electron measurements can be used to constrain multi-TeV internal bremsstrahlung gamma rays arising from annihilation to charged leptons.Comment: 8 pages, 4 figures; minor updates to match published versio

Unidentified EGRET Sources and the Extragalactic Gamma-Ray Background

The large majority of EGRET point sources remain to this day without an identified low-energy counterpart. Whatever the nature of the EGRET unidentified sources, faint unresolved objects of the same class must have a contribution to the diffuse gamma-ray background: if most unidentified objects are extragalactic, faint unresolved sources of the same class contribute to the background, as a distinct extragalactic population; on the other hand, if most unidentified sources are Galactic, their counterparts in external galaxies will contribute to the unresolved emission from these systems. Understanding this component of the gamma-ray background, along with other guaranteed contributions from known sources, is essential in any attempt to use gamma-ray observations to constrain exotic high-energy physics. Here, we follow an empirical approach to estimate whether a potential contribution of unidentified sources to the extragalactic gamma-ray background is likely to be important, and we find that it is. Additionally, we comment on how the anticipated GLAST measurement of the diffuse gamma-ray background will change, depending on the nature of the majority of these sources.Comment: 6 pages, 3 figures, to appear in proceedings of "The Multi-Messenger Approach to High Energy Gamma-Ray Sources", Barcelona, 4-7 July 2006; comments welcom

A luminosity constraint on the origin of unidentified high energy sources

The identification of point sources poses a great challenge for the high energy community. We present a new approach to evaluate the likelihood of a set of sources being a Galactic population based on the simple assumption that galaxies similar to the Milky Way host comparable populations of gamma-ray emitters. We propose a luminosity constraint on Galactic source populations which complements existing approaches by constraining the abundance and spatial distribution of any objects of Galactic origin, rather than focusing on the properties of a specific candidate emitter. We use M31 as a proxy for the Milky Way, and demonstrate this technique by applying it to the unidentified EGRET sources. We find that it is highly improbable that the majority of the unidentified EGRET sources are members of a Galactic halo population (e.g., dark matter subhalos), but that current observations do not provide any constraints on all of these sources being Galactic objects if they reside entirely in the disk and bulge. Applying this method to upcoming observations by the Fermi Gamma-ray Space Telescope has the potential to exclude association of an even larger number of unidentified sources with any Galactic source class.Comment: 18 pages, 4 figures, to appear in JPhys

Deference and Its Dangers: Congress\u27 Power to Define ... Offenses Against the Law of Nations

This Article has not sought to argue that we are today bound to the framers\u27 limited conception of the law of nations. The way that law develops has changed dramatically in 200 years; there is no reason to believe that the framers would not have supported an evolving definition of offenses against the law of nations. And, even if they did not, an originalist interpretation of the offenses clause is still not warranted. Nor has this Article argued that Congress has no leeway in defining offenses; its points are less strict. When Congress determines that a certain set of actions constitutes an offense against the law of nations, it is doing more than establishing a domestic crime. It is putting its imprimatur on certain international practice and saying that that practice has reached a level at which it is binding upon nations. Congress has every reason to be especially careful before reaching such a conclusion. Obviously, if Congress bestows legal status on rules that lack the requisites of a norm--practice and opinio juris--international law suffers. It is hard enough to convince people of the reality of international law without debasing it by giving a false status to some rules. Moreover, where the proposed norm undermines a fundamental right granted by the Constitution, Congress should be wary of codifying its transient views of international practice or the domestic practice of nations with different fundamental values. One of the ironies of Boos is that, now that many nations have begun to march to the beat of the United States\u27 drummer, the United States in one--albeit quite small-way is arguing that it must turn around. Why Congress should deviate from a fundamental domestic norm to achieve at best a minimal foreign policy objective is totally unclear. Determining the norms of customary international law is a complex and often indeterminate enterprise. Congress must exercise its best judgment in making that determination. But there is no reason in theory or practice for the courts to defer to Congress\u27 determination, especially when the resulting laws conflict with the first amendment