Sustainable Innovative Development of Belarus in the Context of Digitalization

В данном исследовании рассматриваются проблемы инновационного развития в условиях цифровизации. Показаны самые современные инновации в Республике Беларусь.In this article we will analyze innovative development, the problems that society faces with innovative development, and the policy of sustainable development. The article shows the most modern innovations in the Republic of Belarus

The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing

Background The gut microbiome is recognized as a pivotal factor in the pathophysiology of sarcopenia—a condition marked by the accelerated loss of muscle strength, mass and function with ageing. Despite this well-known gut-muscle axis, the potential links between other microbial ecosystems and sarcopenia remain largely unexplored. The oral microbiome has been linked to various age-related health conditions such as rheumatoid arthritis and colorectal cancer. However, its potential association with sarcopenia is unknown. The Saliva and Muscle (SaMu) study seeks to address this knowledge gap. Methods The SaMu study comprises three sequential phases. In phase 1, a cross-sectional analysis will be conducted on a cohort of 200 individuals aged 70 years or older to examine the relationship between salivary microbiome and sarcopenia status. Participants will be recruited in the three main places of living: general community, assisted living facilities and nursing homes. The salivary microbiome composition will be evaluated utilizing shotgun metagenomics sequencing, while sarcopenia status will be determined through muscle mass (determined by whole-body bioelectrical impedance analysis and calf circumference), muscle strength (grip strength and the 5-times-sit-to-stand test) and physical performance (usual walking speed). In addition to investigating the microbiome composition, the study aims to elucidate microbiome functions by exploring potential omic associations with sarcopenia. To achieve this, salivary proteomics, metabolomics and quorum sensing peptidomics will be performed. Covariates that will be measured include clinical variables (sociodemographic factors, health status, health-related behaviours, oral health and quality of life) as well as blood variables (immune profiling, hormones, kidney and liver function, electrolytes and haematocrit). In phase 2, an in-depth mechanistic analysis will be performed on an envisaged subcohort of 50 participants. This analysis will explore pathways in muscle tissue using histology, genomics and transcriptomics, focusing on (maximal) 25 healthy older adults and (maximal) 25 with severe sarcopenia. Phase 3 involves a two-year clinical follow-up of the initial participants from the cross-sectional analysis, along with a resampling of blood and saliva. Additionally, secondary outcomes like falls, hospitalization and mortality will be examined. Discussion Using a salivary multi-omics approach, SaMu primarily aims to clarify the associations between the oral microbiome and sarcopenia. SaMu is expected to contribute to the discovery of predictive biomarkers of sarcopenia as well as to the identification of potential novel targets to prevent/tackle sarcopenia. This study-protocol is submitted for registration at the ISRCTN registry.publishedVersio

The interstellar medium towards the Ara OB1 region

We present high resolution (R ~ 4 km/s) absorption measurements of the interstellar NaI and CaII lines measured towards 14 early-type stars of distance 123 pc - 1650 pc, located in the direction of the Ara OB1 stellar cluster. The line profiles can broadly be split into four distinct groupings of absorption component velocity, and we have attempted to identify an origin and distance to each of these interstellar features. For gas with absorption covering the velocity range -10 km/s < V_helio < +10 km/s, we can identify the absorbing medium with local gas belonging to the Lupus-Norma interstellar cavity located between 100 and 485 pc in this galactic direction. Gas with velocities spanning the range -20 km/s < V_helio < +20 km/s is detected towards stars with distances of 570-800 pc. We identify a wide-spread interstellar feature at V_helio ~ -15 km/s with the expanding HI shell called GSH 337+00-05, which is now placed at a distance of ~530 pc.Comment: 12 pages, 5 figures, accepted for publication in Astrophysics & Space Scienc

High-resolution observations of interstellar Na I and Ca II towards the southern opening of the 'Local Interstellar Chimney': probing the disc—halo connection

We present high-resolution (R = 400 000) observations of interstellar Ca II and Na I absorption lines towards seven stars in the direction of the southern opening of the recently identified Local Interstellar Chimney. These lines of sight probe the lower Galactic halo (0.3 ≲∣z∣≲ 2.5 kpc), without the complication of sampling dense foreground interstellar material. In addition to components with velocities expected from Galactic rotation, these stars also exhibit components with negative local standard of rest velocities, which are contrary to the sense of Galactic rotation for the sightlines observed. After a discussion of possible origins for these peculiar velocities, we conclude that at least some of them result from gas falling towards the Galactic plane from distances of ∣z∣≳ 300 pc. The narrow linewidths are generally inconsistent with temperatures as high as the ∼6000 K generally assumed for the so-called Lockman layer. Rather, the picture that emerges is one of a scattered, generally infalling, population of high-∣z∣ diffuse clouds, seemingly not very different from those encountered in the local interstellar medium. Overall, we argue that our results are most consistent with a ‘Galactic fountain’ model

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Riboflavin Binding Protein Chiral Stationary Phase: Investigation on the Retention Mechanism.

The chiral recognition mechanism of Riboflavin Binding Protein (RfBP) stationary phase has been investigated by studying the influence of temperature on the retention process. The effect of temperature on retention and resolution of two analytes was studied between 15°C and 55°C and van't Hoff plots of lnk and ln versus 1/T were acquired. The thermodynamic parameters were calculated and the data were used to derive some information regarding the retention mechanism in this chromatographic system. Quantitative structure-enantioselective retention relationships (QSERR) were derived by multiple regression analysis using various molecular descriptors and the retention data determined on RfBP-stationary phase. The results were interpreted in terms of structural requirements of the specific binding site on the biomacromolecule to provide an insight of the recognition mechanism