Depression, anxiety, and within-person variability in adults aged 18 to 85 years

Mild depression and anxiety were investigated in relation to measures of within-person (WP) variability and mean RT from psychomotor, executive function, visual search, and word recognition tasks in a continuous age range (18 to 85 years, M = 50.33, SD = 20.37) of 300 community-dwelling adults. Structural equation modeling identified a significant Age x Depression interaction in relation to visual search for measures of WP variability but not for mean RT. Older more depressed adults exhibited greater variability. WP variability in executive function and other cognitive constructs covaried, and the significant Age x Depression interaction with visual search was accounted for by WP variability in executive control. The findings suggest that age-, and depression-related reductions in attentional resources may contribute to increased variability in visual search, and that variability in executive control may be the mechanism underlying these effects.This article may not exactly replicate the final version published in the APA journal. It is not the copy of record.This paper has not (yet) been published

Squeezed noise due to two-level system defects in superconducting resonator circuits

Motivated by recent surprising experimental results for the noise output of superconducting microfabricated resonators used in quantum computing applications and astronomy, we develop a fully quantum theoretical model to describe quantum dynamics of these circuits. Building on theoretical techniques from quantum optics, we calculate the noise in the output voltage due to two-level system (TLS) defects. The theory predicts squeezing for the noise in the amplitude quadrature with respect to the input noise, which qualitatively reproduces the noise ellipse observed in experiment. We show that noise enhancement along the phase direction persists for pump frequencies away from resonance. Our results also suggest that intrinsic TLS fluctuations must be incorporated in the model in order to describe the experimentally observed dependence of the phase noise on input power.Comment: 4 pages, 4 figure

Gravitational energy in a small region for the modified Einstein and Landau-Lifshitz pseudotensors

The purpose of the classical Einstein and Landau-Lifshitz pseudotensors is for determining the gravitational energy. Neither of them can guarantee a positive energy in holonomic frames. In the small sphere approximation, it has been required that the quasilocal expression for the gravitational energy-momentum density should be proportional to the Bel-Robinson tensor $B_{\alpha\beta\mu\nu}$. However, we propose a new tensor $V_{\alpha\beta\mu\nu}$ which is the sum of certain tensors $S_{\alpha\beta\mu\nu}$ and $K_{\alpha\beta\mu\nu}$, it has certain properties so that it gives the same gravitational "energy-momentum" content as $B_{\alpha\beta\mu\nu}$ does. Moreover, we show that a modified Einstein pseudotensor turns out to be one of the Chen-Nester quasilocal expressions, while the modified Landau-Lifshitz pseudotensor becomes the Papapetrou pseudotensor; these two modified pseudotensors have positive gravitational energy in a small region.Comment:

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization induced by ultraviolet light C (UVC) or the cancer therapeutic cisplatin, is followed by diversion from the canonical endocytic pathway. Instead of lysosomal degradation or plasma membrane recycling, EGFR accumulates in a subset of LBPA-rich perinuclear multivesicular bodies (MVBs) distinct from those carrying EGF-stimulated EGFR. Stress-internalized EGFR co-segregates with exogenously expressed pre-melanosomal markers OA1 and fibrillar PMEL, following early endosomal sorting by the actin polymerization-promoting WASH complex. Stress-internalized EGFR is retained intracellularly by continued p38 activity in a mechanism involving ubiquitin-independent, ESCRT/ALIX-dependent incorporation onto intraluminal vesicles (ILVs) of MVBs. In contrast to the internalization-independent EGF-stimulated activation, UVC/cisplatin-triggered EGFR activation depends on EGFR internalization and intracellular retention. EGFR signalling from this MVB subpopulation delays apoptosis and might contribute to chemoresistance

Neural Network Model for Apparent Deterministic Chaos in Spontaneously Bursting Hippocampal Slices

A neural network model that exhibits stochastic population bursting is studied by simulation. First return maps of inter-burst intervals exhibit recurrent unstable periodic orbit (UPO)-like trajectories similar to those found in experiments on hippocampal slices. Applications of various control methods and surrogate analysis for UPO-detection also yield results similar to those of experiments. Our results question the interpretation of the experimental data as evidence for deterministic chaos and suggest caution in the use of UPO-based methods for detecting determinism in time-series data.Comment: 4 pages, 5 .eps figures (included), requires psfrag.sty (included

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND)

A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new technique, 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND), for registering medical images with 3D histology to overcome these limitations. Ex vivo 120 × 120 × 200 μm resolution diffusion-MRI (dMRI) data was acquired at 7 T from adult C57Bl/6 mouse hippocampus. Tissue was then optically cleared using CLARITY and stained with cellular markers and confocal microscopy used to produce high-resolution images of the 3D-tissue microstructure. For each sample, a dense array of hippocampal landmarks was used to drive registration between upsampled dMRI data and the corresponding confocal images. The cell population in each MRI voxel was determined within hippocampal subregions and compared to MRI-derived metrics. 3D-BOND provided robust voxel-wise, cellular correlates of dMRI data. CA1 pyramidal and dentate gyrus granular layers had significantly different mean diffusivity (p > 0.001), which was related to microstructural features. Overall, mean and radial diffusivity correlated with cell and axon density and fractional anisotropy with astrocyte density, while apparent fibre density correlated negatively with axon density. Astrocytes, axons and blood vessels correlated to tensor orientation

Evaluating the psychometric properties of the multigroup ethnic identity measure (MEIM) within the United Kingdom

In the present study, we examined the psychometric properties of the Multigroup Ethnic Identity Measure (MEIM) (Phinney, 1992; Phinney & Alipuria, 1990) among an ethnically diverse sample within the United Kingdom. In initial analyses, we evaluated the goodness-of-fit of a one-factor model (i.e., global ethnic identity) and the goodness-of-fit of a two-factor model (i.e., correlated but distinct Exploration and Commitment components). Results of initial confirmatory factor analyses led us to reject both the one-factor and two-factor models. Results of subsequent exploratory and confirmatory factor analyses revealed a three-factor structure (i.e., correlated but distinct Behavioral, Cognitive, and Affective components of ethnic identity) among the sample as a whole (n = 234) and among Asian Indian persons (n = 88) in particular, though resulst were mixed among White U.K./Irish persons (n = 54) in particular. Implications for the study of ethnicity-related concepts in the incerasibgly multi-cultural U.K. are discussed

New positive small vacuum region gravitational energy expressions

We construct an infinite number of new holonomic quasi-local gravitational energy-momentum density pseudotensors with good limits asymptotically and in small regions, both materially and in vacuum. For small vacuum regions they are all a positive multiple of the Bel-Robinson tensor and consequently have positive energy.Comment: 4 page