Propofol and sevoflurane induce distinct burst suppression patterns in rats

Burst suppression is an EEG pattern characterized by alternating periods of high-amplitude activity (bursts) and relatively low amplitude activity (suppressions). Burst suppression can arise from several different pathological conditions, as well as from general anesthesia. Here we review current algorithms that are used to quantify burst suppression, its various etiologies, and possible underlying mechanisms. We then review clinical applications of anesthetic-induced burst suppression. Finally, we report the results of our new study showing clear electrophysiological differences in burst suppression patterns induced by two common general anesthetics, sevoflurane and propofol. Our data suggest that the circuit mechanisms that generate burst suppression activity may differ among general anesthetics

Microwave Spectroscopy

Contains reports on four research projects

Unraveling Anti-Federalist Ideology through a Conceptual Framework of Natural Rights

This master thesis begins with a detailed telling of the history of the Anti-Federalist movement. At the time, the United States was undergoing a huge change. The entire government was in the process of being replaced with a fundamentally different one. Dismantling all pre-existing state and local governments, and forming one unitary government. Some people were understandably fearful of this and Anti-Federalism was born. The Anti-Federalist group was extremely diverse, with internal disagreements on nearly every concept. The author argues that the one thing that all Anti-Federalists mutually agreed upon was the existence of inalienable natural rights including the natural right to self-ownership and the ownership of legitimately gained property. The Anti-Federalists worried that the Constitution contained unsuitable and unspecified objectives for an excessive government, and therefore threatened these natural rights. It was this worry of the extinguishing of natural rights that the Anti-Federalists universally opposed. The author concludes with reflections on researching and writing for the thesis

Unraveling Anti-Federalist Ideology through a Conceptual Framework of Natural Rights

Abstract was created by repository to aid in discovery.This master thesis begins with a detailed telling of the history of the Anti-Federalist movement. At the time, the United States was undergoing a huge change. The entire government was in the process of being replaced with a fundamentally different one. Dismantling all pre-existing state and local governments, and forming one unitary government. Some people were understandably fearful of this and Anti-Federalism was born. The Anti-Federalist group was extremely diverse, with internal disagreements on nearly every concept. The author argues that the one thing that all Anti-Federalists mutually agreed upon was the existence of inalienable natural rights including the natural right to self-ownership and the ownership of legitimately gained property. The Anti-Federalists worried that the Constitution contained unsuitable and unspecified objectives for an excessive government, and therefore threatened these natural rights. It was this worry of the extinguishing of natural rights that the Anti-Federalists universally opposed. The author concludes with reflections on researching and writing for the thesis.SUNY BrockportEducation and Human DevelopmentMaster of Science in Education (MSEd)Education and Human Development Master's These

Why A Few? And Why Not *A Many?

The expressions few and a few are typically considered to be separate quantifiers. I challenge this assumption, showing that with the appropriate definition of few, a few can be derived compositionally as a + few. The core of the analysis is a proposal that few has a denotation as a one-place predicate which incorporates a negation operator. From this, argument interpretations can be derived for expressions such as few students and a few students, differing only in the scope of negation. I show that this approach adequately captures the interpretive differences between few and a few. I further show that other such pairs are blocked by a constraint against the vacuous application of a

Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats

BACKGROUND: Although emergence from general anesthesia is clinically treated as a passive process driven by the pharmacokinetics of drug clearance, agents that hasten recovery from general anesthesia may be useful for treating delayed emergence, emergence delirium, and postoperative cognitive dysfunction. Activation of central monoaminergic neurotransmission with methylphenidate has been shown to induce reanimation (active emergence) from general anesthesia. Cholinergic neurons in the brainstem and basal forebrain are also known to promote arousal. The objective of this study was to test the hypothesis that physostigmine, a centrally acting cholinesterase inhibitor, induces reanimation from isoflurane anesthesia in adult rats. METHODS: The dose-dependent effects of physostigmine on time to emergence from a standardized isoflurane general anesthetic were tested. It was then determined whether physostigmine restores righting during continuous isoflurane anesthesia. In a separate group of rats with implanted extradural electrodes, physostigmine was administered during continuous inhalation of 1.0% isoflurane, and the electroencephalogram changes were recorded. Finally, 2.0% isoflurane was used to induce burst suppression, and the effects of physostigmine and methylphenidate on burst suppression probability (BSP) were tested. RESULTS: Physostigmine delayed time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg (n = 9). During continuous isoflurane anesthesia (0.9% ± 0.1%), physostigmine did not restore righting (n = 9). Blocking the peripheral side effects of physostigmine with the coadministration of glycopyrrolate (a muscarinic antagonist that does not cross the blood-brain barrier) produced similar results (n = 9 each). However, during inhalation of 1.0% isoflurane, physostigmine shifted peak electroencephalogram power from δ ( < 4 Hz) to θ (4-8 Hz) in 6 of 6 rats. During continuous 2.0% isoflurane anesthesia, physostigmine induced large, statistically significant decreases in BSP in 6 of 6 rats, whereas methylphenidate did not. CONCLUSIONS: Unlike methylphenidate, physostigmine does not accelerate time to emergence from isoflurane anesthesia and does not restore righting during continuous isoflurane anesthesia. However, physostigmine consistently decreases BSP during deep isoflurane anesthesia, whereas methylphenidate does not. These findings suggest that activation of cholinergic neurotransmission during isoflurane anesthesia produces arousal states that are distinct from those induced by monoaminergic activation.National Institutes of Health (U.S.) (Grant TR01-GM104948)National Institutes of Health (U.S.) (Grant DP1-OD003646)National Institutes of Health (U.S.) (Grant K08-GM094394

Muon spin rotation and relaxation in magnetic materials

A review of the muon spin rotation and relaxation ($\mu$SR) studies on magnetic materials published from July 1993 is presented. It covers the investigation of magnetic phase diagrams, of spin dynamics and the analysis of the magnetic properties of superconductors. We have chosen to focus on selected experimental works in these different topics. In addition, a list of published works is provided.Comment: Review article, 59 pages, LaTeX with IoP macro

Characteristics of Play Therapy Students in Training.

This study examined if there were characteristic differences between play therapy students and non-play therapy students in training. Specifically, this study was designed to explore what, if any, characteristic differences between play therapy students and non-play therapy students in training exist in the following two areas: (a) personality variables, as measured by the NEO Personality Inventory-Revised (NEO PI-R) and (b) attitude toward children, and measured by the Barnett's Liking of Children Scale (BLOCS). Additionally, this study examined whether certain personality traits and the general attitude toward children for the play therapy student group correlated with the play therapy students' effectiveness ratings assigned to them by their play therapy supervisors. This study found statistically significant differences at the .05 alpha level between the play therapy (N=105) and non-play therapy students (N=79) in training in both the Extraversion personality trait on the NEO PI-R assessment and attitude toward children on the BLOCS. Non-play therapy students were in the High range for Extraversion, whereas play therapy students in training were in the Average range. According to this finding, play therapy students are less extraverted than non-play therapy students. Specifically, a statistically significant difference occurred on the Gregariousness scale of the Extraversion domain between the play therapy and non-play therapy group. Additionally, the play therapy student group scored a statistically significant higher mean total score on the BLOCS, indicating that play therapy students have a more favorable attitude toward children as compared to non-play therapy students in training. No other statistically significant results were indicated on the other personality scales of the NEO PI-R between the play therapy and non-play therapy students in training group. Statistical significance was found on the BLOCS total mean scores between play therapy students rated as "Highly Effective" and play therapy students rated as "Effective" by their play therapy supervisors. This result indicated that play therapists rated as highly effective had an overall more favorable attitude toward children then students rated as effective. Interestingly, the Conscientiousness personality domain was approaching statistical significance for the play therapists rated highly effective as compared to the play therapists that were rated effective. Furthermore, the results of this study quantitatively supported the personal characteristic qualities of play therapists as discussed by Axline (1969) and Landreth (2002)

Microwave Spectroscopy

Contains reports on four research projects

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference