Verification of flow in the vortex chamber devices

За результатами верифікації математичного моделювання у вихрових клапанах і вихрекамерних нагнітачах із закритим виходом, отримано, що найбільш підходящою для розрахунків моделлю є модель нестисливої рідини з урахуванням кривизни ліній струму та обертання потоку на основі SST моделі турбулентності. Вихрекамерні нагнітачі в режимі закритого вихідного каналу та клапани поєднують гідродинамічні особливості течії рідини через них і схожість розподілу тиску вздовж радіусу вихрової камери, а також наявність істотного градієнту тиску вздовж радіусу. Верифікація проведена шляхом порівняння з результатами експериментальних досліджень за інтегральними параметрами: тиск на виході із пристрою, витрата в каналі живлення, витрата, що всмоктується в апарат із зовнішнього середовища. Також вироблялося порівняння за кінематичними параметрами на основі порівняння статичного тиску на верхній торцевій кришці вихрової камери. Більш точні результати отримані для вихрового апарата з радіальним дифузором.Purpose. On the basis of the numerical decision of the Reynolds equations verification of mathematical modeling of vortex valves and vortex chamber superchargers in a mode of the closed exit channel when distributions of pressure along radius of these two devices are similar is conducted. Approach. Verification is made by comparison with results of experimental researches on integrated parameters: pressure upon an exit from the device, the flow rate in the supply channel, the flow rate, which is sucked up in the device from environment. Findings. It is as a result received that the most suitable model is the model of an incompressible fluid with rotation-curvature correction on the basis of SST turbulence model. This model provides the least error at vacuum calculation on an axis of a rotating stream is not dependent on device geometry. Also comparison on kinematics parameters on the basis of static pressure comparison on the top end cover of the vortex chamber was made. More exact results are received for the vortex device with radial diffuser.В результате верификации математического моделирования в вихревых клапанах и вихрекамерных нагнетателях с закрытым выходом, получено, что наиболее подходящей для расчетов моделью является модель несжимаемой жидкости с учетом кривизны линий тока и вращения потока на основе SST модели турбулентности. Вихрекамерные нагнетатели в режиме закрытого выходного канала, и клапаны объединяют гидродинамические особенности течения жидкости через них и схожесть распределения давления вдоль радиуса вихревой камеры, а также наличие существенного градиента давления вдоль радиуса. Верификация проведена путем сравнения с результатами экспериментальных исследований по интегральным параметрам: давление на выходе из устройства, расход в питающем канале, расход, всасываемый в аппарат из внешней среды. Также производилось сравнение и по кинематическим параметрам на основе сравнения статического давления на верхней торцевой крышке вихревой камеры. Более точные результаты получены для вихревого аппарата с радиальным диффузором

Mosquitoes LTR Retrotransposons: A Deeper View into the Genomic Sequence of Culex quinquefasciatus

A set of 67 novel LTR-retrotransposon has been identified by in silico analyses of the Culex quinquefasciatus genome using the LTR_STRUC program. The phylogenetic analysis shows that 29 novel and putatively functional LTR-retrotransposons detected belong to the Ty3/gypsy group. Our results demonstrate that, by considering only families containing potentially autonomous LTR-retrotransposons, they account for about 1% of the genome of C. quinquefasciatus. In previous studies it has been estimated that 29% of the genome of C. quinquefasciatus is occupied by mobile genetic elements

Фотодинамическая терапия в лечении плоскоклеточного рака слизистой оболочки полости рта и нижней губы

Treatment outcomes in 82 patients with primary and recurrent oral and lower lip cancer after photodynamic therapy with photosensitizer Photolon alone or combined with other methods of cancer treatment are represented. According to type and extent of the tumor the single dose of Photolon for intravenous administration accounted for 0.8–2.5 mg/kg, light dose – 100–400 J/cm2 (with wave length of 661 nm). 57 patients had PDT alone; 5 patients – in combination with distant radotherapy; 11 – with distant radiotherapy and polychemotherapy; 9 – with 252Cf interstitial therapy and polychemotherapy. For these patients 3-year overall survival rates were 85.1±4.8%, 3-year reccurence-free survival – 72.2±4.7%. The PDT for recurrent tumors, in cases when other methods were exhausted or impossible, allowed complete tumor response in 82.9% of patients, in 72.9% of them – 3-year disease free survivance. For PDT combined with distant radiotherapy (including concurrent polychemotherapy) the complete response was observed in 100% of patients with primary tumor and in 66.7% of patients with recurrent tumor. For PDT combined with interstitial neutron therapy all patients had complete tumor response. The study showed that this combination allowed decreasing the total radiation dose and radiation dose on adjacent normal tissue, thus, decreasing radiation injury. Приведены результаты лечения 82 пациентов с первичным и рецидивным раком слизистой оболочки полости рта и нижней губы методом фотодинамической терапии (ФДТ) с фотосенсибилизатором фотолон как в самостоятельном варианте, так и в различных сочетаниях с другими видами противоопухолевой терапии. В зависимости от формы и распространенности опухоли доза фотолона для однократного внутривенного введения составляла 0,8–2,5 мг/кг массы тела, световая доза облучения – 100-400 Дж/см2 (на длине волны 661 нм). 57 больным ФДТ была проведена в режиме монотерапии; 5 пациентам – в сочетании с дистанционной лучевой терапией; 11 – в сочетании с дистанционной лучевой терапией и полихимиотерапией; 9 – в сочетании с внутритканевой терапией 252Cf и полихимиотерапией. После проведенного лечения трёхлетняя общая выживаемость пациентов составила 85,1±4,8%, трёхлетняя безрецидивная – 72,2±4,7%. Применение ФДТ при рецидивных новообразованиях, когда другие методы лечения были исчерпаны или невозможны, позволило у 82,9% больных достичь полной резорбции опухоли, из них у 72,9% – стойкого излечения в течение трех лет. При применении ФДТ в сочетании с дистанционной лучевой терапией (в том числе одновременно с полихимиотерпией) у 100% пациентов с первичной опухолью и у 66,7% пациентов с рецидивной опухолью эффектом лечения была полная резорбция. При сочетании ФДТ с внутритканевой нейтронной терапией полной регрессии опухоли удалось достичь у всех пролеченных пациентов. Исследования показали, что в таком сочетании ФДТ позволяет снизить дозу лучевой терапии и уменьшить лучевую нагрузку на здоровые окружающие ткани, то есть снизить вероятность развития лучевых повреждений.

Issledovanie vlijanija tormoznogo ustrojjstva na dinamicheskie kharakteristiki ehlektropnevmaticheskogo klapana

The results of mathematical simulation of dynamic processes of opening and closing electro-pneumatic valve and optimization of geometrical parameters of brake device are presented.Приведены результаты математического моделирования динамических процессов при открытии и закрытии электропневматического клапана и оптими

Endovideosurgical aspects of treatment of bilateral inguinal hernias

OBJECTIVE. The article detected risk factors of supravesial hernia formation and its recurrence in patients with bilateral inguinal hernias after laparoscopic herniaplasty. The authors would like to develop strategy in order to solve this problem. MATERIAL AND METHODS. An analysis of treatment results was made in 84 patients. The research was based on ultrasound clinical data at the period of 3-5 years after operation. RESULTS. Factors of high recurrence rate and supravesial herhia formation were identified as combination of features of work activity and increased physical exertion accompanied by chronic diseases and regular intra-abdominal rise of pressure. The algorithm of choice among various laparoscopic methods of surgery was designed. Total prosthesis of supravesial and inguinal regions using developed original technique is recommended for application in cases of high risk group. Standard separate hernioplasty could be used in an absence of high risk. CONCLUSIONS. The proposed algorithm allowed doctors to reduce the rate of recurrence and formation of supravesial hernias

Diagnosis and surgical treatment of acute intestinal obstruction caused by extragenital form of endometriosis

Damage to the gastrointestinal tract with extragenital endometriosis is a very rare pathology. According to the literature, the frequency of damage to the gastrointestinal tract in endometriosis, after previously performed gynecological operations, is less than 1%. At the same time, involvement in the pathological process of the intestine is noted in 337% of women of childbearing age with diagnosed genital endometriosis. In most clinical cases extragenital endometriosis occurs intraoperatively due to the complexity of early diagnosis.&#x0D; This article presents a clinical case of successful surgical treatment of a 43-year-old patient admitted to a surgical department with signs of intestinal obstruction. According to the anamnesis the patient had been suffering from recurrent pains in the lower abdomen in the right mesogastrium and constipation. The day before hospitalization, the above mentioned symptoms become worse with additional nausea, vomiting, lack of gases and feces. Based on the clinical laboratory and instrumental data the diagnosis of acute intestinal obstruction was established; and the urgent surgical treatment was carried out. Two formations were revealed intraoperatively (in the terminal ileum and in the elongated loop of the sigmoid colon). Both formations circularly narrowed the intestinal lumen, however the ileum was the cause of obstruction. Due to the lack of histological verification and the inability to exclude the malignant nature of the formation, the surgical treatment was carried out taking into account oncological standard in the amount of ileum resection and obstructive resection of the sigmoid colon with lymphadenectomy and small intestine intubation. Pathohistological examination confirmed intestinal endometriosis. The course of the postoperative period revealed no complications. The patient was discharged on the 12th day for outpatient treatment under the supervision of a surgeon and a gynecologist at the place of residence with recommendations and subsequent planned hospitalization in order to conduct reconstructive surgery to restore intestinal patency.</jats:p

Endovideosurgical aspects of treatment of bilateral inguinal hernias

OBJECTIVE. The article detected risk factors of supravesial hernia formation and its recurrence in patients with bilateral inguinal hernias after laparoscopic herniaplasty. The authors would like to develop strategy in order to solve this problem. MATERIAL AND METHODS. An analysis of treatment results was made in 84 patients. The research was based on ultrasound clinical data at the period of 3-5 years after operation. RESULTS. Factors of high recurrence rate and supravesial herhia formation were identified as combination of features of work activity and increased physical exertion accompanied by chronic diseases and regular intra-abdominal rise of pressure. The algorithm of choice among various laparoscopic methods of surgery was designed. Total prosthesis of supravesial and inguinal regions using developed original technique is recommended for application in cases of high risk group. Standard separate hernioplasty could be used in an absence of high risk. CONCLUSIONS. The proposed algorithm allowed doctors to reduce the rate of recurrence and formation of supravesial hernias.</jats:p