A comparison of mother and father reports of children’s theory of mind: further validation of the children’s social understanding scale

The reliability and validity of the Children’s Social Understanding Scale (CSUS) was further assessed by examining fathers’ as well as mothers’ reports of children’s social understanding, along with behavioural measures of children’s mental state understanding. 112 families with children aged 38 to 64 months participated with both parents filling out the CSUS, while children were administered a language test and a battery of Theory of Mind (ToM) tasks. Internal consistency of the CSUS was high for both mothers and fathers, and maternal and paternal CSUS scores were moderately-highly correlated. In addition, mothers’ and fathers’ CSUS responses were each associated with children’s behavioural ToM, even after controlling for age and verbal ability. Finally, both parents appeared to have roughly equally strong insights into their children’s ToM and each parent’s insight did not appear to add novel information about ToM over and above that of the other parent. These findings suggest that the CSUS is a reliable and valid tool in assessment of ToM by both mothers and fathers, and that researchers can safely use either one or the other as a complement to behavioural performance in studying ToM

A PRELIMINARY REPORT OF PEDIATRIC AUTOIMMUNE NEUROPSYCHIATRIC DISORDERS ASSOCIATED WITH STREPTOCOCCUS (PANDAS) RELATED MATERNAL AUTOIMMUNITY

WOS: 000215799101008

False allegation in abuse cases: A case report [Istismar olgularinda asilsiz bildiri: Bir olgu sunumu]

Abuse and its complications are the important part of child and adolescent psychiatry services. Professionals who worked in this area can be faced with false abuse allegation. Treatment, ethic and forensic necessity are the most important difficulties in these cases. The aims of this study are to inform about of the false allegation case whose legal reporting procedures initiated by clinicians and to discuss this case from psychiatric, forensic and ethical point of views

Comparison of two methods for hemoglobin A2 measurement

31st Congress of the Federation-of-European-Biochemical-Societies (FEBS) -- JUN 24-29, 2006 -- Istanbul, TURKEYWOS: 000238914002430…Federat European Biochem So

MitraClip therapy in patients with acute severe mitral regurgitation

Abstract Background There is a lack of data to support the optimal management of high-risk patients with acute severe mitral regurgitation (MR). The role of the MitraClip implantation in treatment of acute severe mitral regurgitation (MR) is undetermined. Methods We screened all patients who underwent MitraClip implantation at the Hadassah Medical Center between October 2015 and December 2019. We evaluated immediate, 30-day and 1-year outcomes after the procedure. We evaluated patients with severe MR due to ruptured cord because of degenerative disease and acute-on-chronic functional MR due to ischemic (after a recent myocardial infarction (MI)) or non-ischemic etiology (secondary to decompensated HF). Results From a cohort of 151 patients, who underwent MitraClip implantation in our center, we identified 35 patients (23.2%) with acute severe mitral regurgitation (4+) and decompensated refractory heart failure. Patients' mean age was 74.15 years, 66.9% - were males. One, 2, or 3 clips were implanted. Reduction of MR from 4+ to 1+ was achieved in 34 patients (66.7%). Twenty-eight patients (80%) had acute-on-chronic severe MR and refractory heart failure including 6 cases after recent MI, other 7 patients presented with heart failure and acute severe MR secondary to ruptured cord due to degenerative disease. After MitraClip implantation, reduction of MR severity was achieved in all patients. Seven patients were withdrawn from intravenous therapy and intra-aortic balloon pump 2–3 days after the procedure. Four patients died during hospitalization, three of them due to sepsis. 30-day follow-up showed improvement of NYHA functional class and a tendency toward improvement in left ventricle systolic function with signs of reverse remodeling. Nevertheless, we observed high 30-day and 1-year mortality rate (11.4 and 23.8% respectively). Conclusions MitraClip therapy could be an alternative option for treatment of patients with acute and acute-on-chronic severe MR of ischemic and non-ischemic etiology. Funding Acknowledgement Type of funding source: None </jats:sec

The effect of a de novo pericentric inversion (10)(p11.1;q22.1) on aggressive behavior and hyperactivity

PubMedID: 19400544[No abstract available

ASSOCIATION BETWEEN OBSESSIVE COMPULSIVE DISORDER AND TUMOR NECROSIS FACTOR-alpha GENE-308 (G > A) AND-850 (C > T) POLYMORPHISMS IN TURKISH CHILDREN

WOS: 000318406300008PubMed ID: 24052733Obsessive compulsive disorder (OCD) is a neurobio-logical disease characterized with obsessions and compulsions. Obsessive compulsive disorder occurs with an autoimmune mechanism after Group A beta hemolytic streptococcus (GABHS) infection. Tumor necrosis factor (TNF) is an important cytokine, as well as having an important role in the apoptosis mechanism of autoimmune diseases. It is expressed by the TNF-alpha gene. The aim of this study was to examine the relationship between the TNF-a gene promoter region -308 (G>A) and -850 (C>T) polymor-phisms and OCD. In this study, ages of the OCD patients and the control group ranged between 4 and 12 years. We studied two patient groups, one included childhood onset OCD patients (n = 49) and the control group was composed of healthy children (n = 58). Patients were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorder (DSM-IV) criteria and with Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime (KSAD-S-PL) version. For identifying the poly-morphisms, polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and polyacryl-amide gel electrophoresis (PAGE) methods were used. For the -308 polymorphism, 45 of 49 OCD patients' results were completed, and for the -850 polymorphism, 47 of 49 OCD patients' results were completed. According to our statistical results, there is a positive relationship between OCD and the -308 polymorphism (p <0.001) but no association between OCD and the -850 polymorphism (p = 0.053). There is no positive relationship between antistreptolysin O (ASO) titers and the -308 polymorphism (p = 0.953) but there is an important significance between the -850 polymorphism and ASO (p = 0.010). There is no positive relationship between gender of patients and OCD (p = 0.180) and no positive association between ASO and gender (p = 0.467). According to our results, we hypothesize that we can propose the mutant AA genotype for the -308 polymorphism, and that the mutant CT genotype for the -850 polymorphism may be used as molecular indicators for OCD

Mannose-binding lectin 2 gene polymorphism in PANDAS patients

Introduction: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a subgroup of obsessive-compulsive disorder (OCD), has received much attention even though the specific underlying mechanisms remain unknown. Mannose-binding lectin (MBL) is a key factor in the innate immune response. The aim of this study was to investigate the role of MBL2 gene polymorphisms in pediatric OCD patients diagnosed as PANDAS, PANDAS-Variant and non-PANDAS. Methods: The study included 102 pediatric OCD patients (59 [57.8% ] PANDAS, 20 [19.6% ] non-PANDAS, and 23 [22.5% ] PANDAS-Variant) and 60 healthy controls. Polymorphisms at codon 52, 54 and 57 of the MBL2 gene were investigated. Results: Codon 54 polymorphism and any variant of MBL2 gene were significantly more frequent in the OCD group than in the control group (OR=2.97, 95% CI: 1.26–6.97; and OR=2.66, 95% CI: 1.32–5.38, respectively). According to regression analysis, the presence of any variant of MBL2 gene was found in 14.50-fold increased frequency in the PANDAS subgroup compared with the non-PANDAS subgroup (95% CI: 2.49–84.19). Conclusions: Our findings support an association between MBL2 genotypes and pediatric OCD, particularly PANDAS-OCD. © 2018 by Turkish Association of Neuropsychiatry.TF2011BAP36Acknowledgements: This study was presented as a poster at the 21st National Child and Adolescent Psychiatry Meeting, Antalya, Turkey, 2011. This study received the Best Research Project Award from the National Association for Child and Adolescent Psychiatry in 2010. Ethics Committee Approval: The project was approved by the Ethics Committee of the Çukurova University (B.10 OTHG. 0.79.00.07). Informed Consent: Informed consent was obtained from all of the patients and their parents. Peer-review: Externally peer-reviewed. Author Contributions: Concept - GGÇ, DAT; Design - GS, EE; Supervision - AA, PÇR; Resource - AYT; Materials - EE; Data Collection and/ or Processing - GGÇ; Analysis and/ or Interpretation - GS, GGÇ; Literature Search -PY, GGÇ; Writing - GGÇ, AYT; Critical Reviews - DAT, AA, GGÇ. Conflict of Interest: The authors do not have any conflict of interest to report regarding this study. Financial Disclosure: The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: The work was supported by grants from the Çukurova University Scientific Research Department, Adana, Turkey (TF2011BAP36)