Optimal cloning of mixed Gaussian states

We construct the optimal 1 to 2 cloning transformation for the family of displaced thermal equilibrium states of a harmonic oscillator, with a fixed and known temperature. The transformation is Gaussian and it is optimal with respect to the figure of merit based on the joint output state and norm distance. The proof of the result is based on the equivalence between the optimal cloning problem and that of optimal amplification of Gaussian states which is then reduced to an optimization problem for diagonal states of a quantum oscillator. A key concept in finding the optimum is that of stochastic ordering which plays a similar role in the purely classical problem of Gaussian cloning. The result is then extended to the case of n to m cloning of mixed Gaussian states.Comment: 8 pages, 1 figure; proof of general form of covariant amplifiers adde

Dissolved noble gases and stable isotopes as tracers of preferential fluid flow along faults in the Lower Rhine Embayment, Germany

Groundwater in shallow unconsolidated sedimentary aquifers close to the Bornheim fault in the Lower Rhine Embayment (LRE), Germany, has relatively low δ2H and δ18O values in comparison to regional modern groundwater recharge, and 4He concentrations up to 1.7 × 10−4 cm3 (STP) g–1 ± 2.2 % which is approximately four orders of magnitude higher than expected due to solubility equilibrium with the atmosphere. Groundwater age dating based on estimated in situ production and terrigenic flux of helium provides a groundwater residence time of ∼107 years. Although fluid exchange between the deep basal aquifer system and the upper aquifer layers is generally impeded by confining clay layers and lignite, this study’s geochemical data suggest, for the first time, that deep circulating fluids penetrate shallow aquifers in the locality of fault zones, implying  that sub-vertical fluid flow occurs along faults in the LRE. However, large hydraulic-head gradients observed across many faults suggest that they act as barriers to lateral groundwater flow. Therefore, the geochemical data reported here also substantiate a conduit-barrier model of fault-zone hydrogeology in unconsolidated sedimentary deposits, as well as corroborating the concept that faults in unconsolidated aquifer systems can act as loci for hydraulic connectivity between deep and shallow aquifers. The implications of fluid flow along faults in sedimentary basins worldwide are far reaching and of particular concern for carbon capture and storage (CCS) programmes, impacts of deep shale gas recovery for shallow groundwater aquifers, and nuclear waste storage sites where fault zones could act as potential leakage pathways for hazardous fluids

Ten Years of Experience Training Non-Physician Anesthesia Providers in Haiti.

Surgery is increasingly recognized as an effective means of treating a proportion of the global burden of disease, especially in resource-limited countries. Often non-physicians, such as nurses, provide the majority of anesthesia; however, their training and formal supervision is often of low priority or even non-existent. To increase the number of safe anesthesia providers in Haiti, Médecins Sans Frontières has trained nurse anesthetists (NAs) for over 10 years. This article describes the challenges, outcomes, and future directions of this training program. From 1998 to 2008, 24 students graduated. Nineteen (79%) continue to work as NAs in Haiti and 5 (21%) have emigrated. In 2008, NAs were critical in providing anesthesia during a post-hurricane emergency where they performed 330 procedures. Mortality was 0.3% and not associated with lack of anesthesiologist supervision. The completion rate of this training program was high and the majority of graduates continue to work as nurse anesthetists in Haiti. Successful training requires a setting with a sufficient volume and diversity of operations, appropriate anesthesia equipment, a structured and comprehensive training program, and recognition of the training program by the national ministry of health and relevant professional bodies. Preliminary outcomes support findings elsewhere that NAs can be a safe and effective alternative where anesthesiologists are scarce. Training non-physician anesthetists is a feasible and important way to scale up surgical services resource limited settings

Cochlea-inspired tonotopic resonators

The cochlea has long been the subject of investigation in various research fields due to its intriguing spiral architecture and unique sensing characteristics. One of its most interesting features is tonotopy, the ability to sense acoustic waves at different spatial locations based on their frequency content. In this work, we propose a novel design for a tonotopic resonator, based on a cochlea-inspired spiral, which can discriminate the frequency content of elastic waves without the use of sub-wavelength resonators. The structure is the result of an optimization process to display a uniform distribution of displacement maxima along its centreline for frequencies spanning nearly a two-decade range, while maintaining a compact design. Numerical simulations are performed to demonstrate the concept and experimental measurements to validate it on a 3D printed structure. The resulting frequency-dependent distribution is also shown to be a viable means to discriminate signals with various frequency components. We also show that for appropriate parameter ranges, the tonotopic behaviour can be inverted, i.e., lower frequencies can be made to concentrate in narrower regions, as happens in the real cochlea. The harnessed tonotopic features can be used as a fundamental principle to design structures with applications in areas such as non-destructive testing and vibration attenuation

Bottom up ethics - neuroenhancement in education and employment

Neuroenhancement involves the use of neurotechnologies to improve cognitive, affective or behavioural functioning, where these are not judged to be clinically impaired. Questions about enhancement have become one of the key topics of neuroethics over the past decade. The current study draws on in-depth public engagement activities in ten European countries giving a bottom-up perspective on the ethics and desirability of enhancement. This informed the design of an online contrastive vignette experiment that was administered to representative samples of 1000 respondents in the ten countries and the United States. The experiment investigated how the gender of the protagonist, his or her level of performance, the efficacy of the enhancer and the mode of enhancement affected support for neuroenhancement in both educational and employment contexts. Of these, higher efficacy and lower performance were found to increase willingness to support enhancement. A series of commonly articulated claims about the individual and societal dimensions of neuroenhancement were derived from the public engagement activities. Underlying these claims, multivariate analysis identified two social values. The Societal/Protective highlights counter normative consequences and opposes the use enhancers. The Individual/Proactionary highlights opportunities and supports use. For most respondents these values are not mutually exclusive. This suggests that for many neuroenhancement is viewed simultaneously as a source of both promise and concern

Cochlea-inspired tonotopic resonators

The cochlea has long been the subject of investigation in various research fields due to its intriguing spiral architecture and unique sensing characteristics. One of its most interesting features is tonotopy, the abil- ity to sense acoustic waves at different spatial locations based on their frequency content. In this work, we propose a novel design for a tonotopic resonator, based on a cochlea-inspired spiral, which can dis- criminate the frequency content of elastic waves without the use of sub-wavelength resonators. The structure is the result of an optimization process to obtain a uniform distribution of displacement max- ima along its centreline for frequencies spanning nearly two-decades, while maintaining a compact design. Numerical simulations are performed to demonstrate the concept and experimental measure- ments to validate it on a 3D printed structure. The resulting frequency-dependent distribution is also shown to be a viable means to discriminate signals with various frequency components. We also show that for appropriate parameter ranges, the tonotopic behaviour can be inverted, i.e., lower frequencies can be made to concentrate in narrower regions, as happens in the real cochlea. The harnessed tonotopic features can be used as a fundamental principle to design structures with applications in areas such as non-destructive testing and vibration attenuation

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.

Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb uses the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT), which induces necrosis by an unknown mechanism. Here we show that TNT gains access to the cytosol of Mtb-infected macrophages, where it hydrolyzes the essential coenzyme NAD(+). Expression or injection of a noncatalytic TNT mutant showed no cytotoxicity in macrophages or in zebrafish zygotes, respectively, thus demonstrating that the NAD(+) glycohydrolase activity is required for TNT-induced cell death. To prevent self-poisoning, Mtb produces an immunity factor for TNT (IFT) that binds TNT and inhibits its activity. The crystal structure of the TNT-IFT complex revealed a new NAD(+) glycohydrolase fold of TNT, the founding member of a toxin family widespread in pathogenic microorganisms

Revisiting the transatlantic divergence over GMOs: Toward a cultural-political analysis

'Revisiting the transatlantic divergence over GMOs: towards a cultural-political analysis' applies a constructivist perspective to the persistent transatlantic divergence over the regulation of GM foods and crops. Political economy and institutionalism have so far dominated the literature. Notwithstanding their crucial insights, this article argues that to achieve a better understanding of the nature and depth of transatlantic regulatory divergence, one should also study prevalent cultural values and identity-related public concerns regarding food and agriculture. These factors can be identified in public opinion trends and have fuelled Europeans' resistance, while contributing to relative regulatory stability in the US. By conceptualizing cultural contexts as catalytic structures, the article also differs from more explicitly discursive accounts of political mobilization. The cultural politics of agricultural biotechnology (agbiotech) relies both on pre-existing values and identities, on the one hand, and on the strategies (and material or other power resources) of political agents

Tiny Publics and Social Worlds—Toward a Sociology of the Local. Gary Alan Fine in Conversation With Reiner Keller

Gary Alan FINE gehört weltweit zu den prominentesten Persönlichkeiten der zeitgenössischen soziologischen Ethnografie. In diesem Gespräch spricht er über Einflüsse in seiner akademischen Laufbahn und prägende intellektuelle Entscheidungen. Er gilt als "serieller Ethnograf", der in zahlreichen Feldkontexten gearbeitet hat und dabei einerseits Kleingruppen und eine von Menschen bevölkerte Ethnografie favorisiert, sich andererseits mit Gerüchten, Klatsch und moralischen Geschichten beschäftigt, die in kleinen und größeren Publiken erzählt werden. FINE beschreibt sein theoretisches Kerninteresse als die Untersuchung des Wechselspiels von Struktur, Interaktion und Kultur. In seinem Werk analysiert er die vielfältigen ortsgebundenen Arten und Weisen, in denen Gesellschaft von Menschen in formellen und informellen sozialen Settings verwirklicht wird, angefangen bei Baseballteams über Restaurantküchen oder die Wetterberichterstattung bis hin zum Schachspielen –um nur einige wenige Gegenstände seiner Forschungen zu nennen. Wesentlich beeinflusst durch symbolisch-interaktionistisches Denken und im Rekurs auf weitere wichtige Perspektiven auf soziale Welten plädiert er für eine selbstbewusste Haltung der ethnografischen Forschung und des ethnografischen Schreibens sowie für die Bedeutung der Konzeptarbeit in einer theorie-informierten empirischen Soziologie dessen, was Menschen zusammen tun.Gary Alan FINE is among the most prominent figures in contemporary sociological ethnography worldwide. In this conversation, he talks about influences in his academic career and key intellectual choices. Considered to be a "serial ethnographer" who has worked in multiple settings, his work focuses on small groups and peopled ethnography, as well as on rumors, gossip, and moral story telling in tiny and larger publics. FINE describes his core theoretical interest as residing in the interplay of structure, interaction, and culture and discusses the multiple local ways society is realized by people in formal and informal social settings: ranging from baseball teams, restaurant kitchens, weather reporting to chess players—to name but a few research sites. Influenced by symbolic interactionist thinking and other important approaches to social worlds, he argues for a confident voice of ethnographic research and writing as well as the importance of conceptual work in a theory-informed empirical sociology of what people do together

Instructed late binding

Integration of a decentralised pattern matching is a technique that enables a recent solution to the Expression Problem. The single former implementation of this technique was in Scala. In this paper, we highlight the C++ implementation of the same technique to solve the Expression Problem in C++. Unlike the former implementation which relies on stackability of Scala traits, this new implementation relies on compile-time metaprogramming for automatic iterative pointer introspection at runtime. That iteration enables late binding using overload resolution, which the compiler is already capable of. The C++ implementation outperforms the Scala one by providing strong static type safety and offering considerably easier usage