Etude de la pathologie de la reproduction chez les bovins en Afrique centrale : enquête sur la chlamydiose et la fièvre Q

Les auteurs analysent 490 sérums de vaches du Nord Cameroun ayant avorté, en comparant les résultats obtenus pour la chlamydiose et la fièvre Q par rapport à la brucellose : 11, 4 p. 100 des prélèvements sont positifs pour la chlamydiose, 2, 9 p. 100 pour la fièvre Q, contre 50, 2 p. 100 pour la brucellose. Les résultats sont commentés. Les pourcentages de positivité, pour la chlamydiose et la fièvre Q, calculés sur une enquête complémentaire effectuée sur des vaches reproductrices prises au hasard, ainsi que les taux cités par d'autres chercheurs, sont rapprochés de ceux du groupe des vaches ayant avorté. La conclusion avancée est que chlamydiose et fièvre Q semblent peu importantes dans l'étiologie de l'avortement bovin en Afrique centrale et, en tout état de cause, beaucoup moins fréquentes que la brucellos

Design of a robust railway line system for severe winter conditions in The Netherlands

Winter weather has a major impact on railway operations in The Netherlands. To stay in control, the number of trains is reduced by half in a special “winter timetable”. This results in a more robust network, but an insufficient amount of transport capacity. Adapting the line system can result in more transport capacity without losing robustness. This paper therefore focuses on the performance of a line system under extreme weather conditions. We define several criteria to assess the performance of the line system in terms of robustness and transport capacity. A case study has been conducted on the railway network in The Netherlands, which indicates that all alternatives are more robust and yield more transport capacity than the current winter timetable

Simultaneous Multi-Wavelength Observations of Sgr A* during 2007 April 1-11

We report the detection of variable emission from Sgr A* in almost all wavelength bands (i.e. centimeter, millimeter, submillimeter, near-IR and X-rays) during a multi-wavelength observing campaign. Three new moderate flares are detected simultaneously in both near-IR and X-ray bands. The ratio of X-ray to near-IR flux in the flares is consistent with inverse Compton scattering of near-IR photons by submillimeter emitting relativistic particles which follow scaling relations obtained from size measurements of Sgr A*. We also find that the flare statistics in near-IR wavelengths is consistent with the probability of flare emission being inversely proportional to the flux. At millimeter wavelengths, the presence of flare emission at 43 GHz (7mm) using VLBA with milli-arcsecond spatial resolution indicates the first direct evidence that hourly time scale flares are localized within the inner 30$\times$70 Schwarzschild radii of Sgr A*. We also show several cross correlation plots between near-IR, millimeter and submillimeter light curves that collectively demonstrate the presence of time delays between the peaks of emission up to three hours. The evidence for time delays at millimeter and submillimeter wavelengths are consistent with the source of emission being optically thick initially followed by a transition to an optically thin regime. In particular, there is an intriguing correlation between the optically thin near-IR and X-ray flare and optically thick radio flare at 43 GHz that occurred on 2007 April 4. This would be the first evidence of a radio flare emission at 43 GHz delayed with respect to the near-IR and X-ray flare emission.Comment: replaced with revised version 57 pages, 28 figures, ApJ (in press

The two states of Sgr A* in the near-infrared: bright episodic flares on top of low-level continuous variability

In this paper we examine properties of the variable source Sgr A* in the near-infrared (NIR) using a very extensive Ks-band data set from NACO/VLT observations taken 2004 to 2009. We investigate the variability of Sgr A* with two different photometric methods and analyze its flux distribution. We find Sgr A* is continuously emitting and continuously variable in the near-infrared, with some variability occurring on timescales as long as weeks. The flux distribution can be described by a lognormal distribution at low intrinsic fluxes (<~5 mJy, dereddened with A_{Ks}=2.5). The lognormal distribution has a median flux of approximately 1.1 mJy, but above 5 mJy the flux distribution is significantly flatter (high flux events are more common) than expected for the extrapolation of the lognormal distribution to high fluxes. We make a general identification of the low level emission above 5 mJy as flaring emission and of the low level emission as the quiescent state. We also report here the brightest Ks-band flare ever observed (from August 5th, 2008) which reached an intrinsic Ks-band flux of 27.5 mJy (m_{Ks}=13.5). This flare was a factor 27 increase over the median flux of Sgr A*, close to double the brightness of the star S2, and 40% brighter than the next brightest flare ever observed from Sgr~A*.Comment: 14 pages, 6 figures, accepted for publication in Ap

Bursting behavior of the Galactic Center faint X-ray transient GRS 1741.9-2853

The neutron star low-mass X-ray binary GRS 1741.9-2853 is a known type-I burster of the Galactic Center. It is transient, faint, and located in a very crowded region, only 10 arcmin from the supermassive black hole Sgr A*. Therefore, its bursting behavior has been poorly studied so far. In particular, its persistent emission has rarely been detected between consecutive bursts, due to lack of sensitivity or confusion. This is what made GRS 1741.9-2853 one of the nine "burst-only sources" identified by BeppoSAX a few years ago. The physical properties of GRS 1741.9-2853 bursts are yet of great interest since we know very little about the nuclear regimes at stake in low accretion rate bursters. We examine here for the first time several bursts in relation with the persistent emission of the source, using INTEGRAL, XMM-Newton, and Swift observations. We investigate the source flux variability and bursting behavior during its 2005 and 2007 long outbursts. The persistent luminosity of GRS 1741.9-2853 varied between ~1.7 and 10.5 10^36 erg s^-1, i.e. 0.9-5.3% of the Eddington luminosity. The shape of the spectrum as described by an absorbed power-law remained with a photon index Gamma ~ 2 and a column density $N_{\rm H} ~ 12 10^22 cm^-2 throughout the outbursts. We discovered 11 type-I bursts with INTEGRAL, and inspected 4 additional bursts: 2 recorded by XMM-Newton and 2 by Swift. From the brigthest burst, we derive an upper limit on the source distance of ~7 kpc. The observed bursts characteristics and source accretion rate suggest pure helium explosions igniting at column depths y_{ign} ~ 0.8-4.8 10^8 g cm^-1, for typical energy releases of ~1.2-7.4 10^39 erg.Comment: 11 pages, 7 figures, accepted for publication in A&

The COSPIX mission: focusing on the energetic and obscured Universe

Tracing the formation and evolution of all supermassive black holes, including the obscured ones, understanding how black holes influence their surroundings and how matter behaves under extreme conditions, are recognized as key science objectives to be addressed by the next generation of instruments. These are the main goals of the COSPIX proposal, made to ESA in December 2010 in the context of its call for selection of the M3 mission. In addition, COSPIX, will also provide key measurements on the non thermal Universe, particularly in relation to the question of the acceleration of particles, as well as on many other fundamental questions as for example the energetic particle content of clusters of galaxies. COSPIX is proposed as an observatory operating from 0.3 to more than 100 keV. The payload features a single long focal length focusing telescope offering an effective area close to ten times larger than any scheduled focusing mission at 30 keV, an angular resolution better than 20 arcseconds in hard X-rays, and polarimetric capabilities within the same focal plane instrumentation. In this paper, we describe the science objectives of the mission, its baseline design, and its performances, as proposed to ESA.Comment: 7 pages, accepted for publication in Proceedings of Science, for the 25th Texas Symposium on Relativistic Astrophysics (eds. F. Rieger &amp; C. van Eldik), PoS(Texas 2010)25

Soft gamma-ray constraints on a bright flare from the Galactic Center supermassive black hole

Sagittarius A* (Sgr A*) is the supermassive black hole residing at the center of the Milky Way. It has been the main target of an extensive multiwavelength campaign we carried out in April 2007. Herein, we report the detection of a bright flare from the vicinity of the horizon, observed simultaneously in X-rays (XMM/EPIC) and near infrared (VLT/NACO) on April 4th for 1-2 h. For the first time, such an event also benefitted from a soft gamma-rays (INTEGRAL/ISGRI) and mid infrared (VLT/VISIR) coverage, which enabled us to derive upper limits at both ends of the flare spectral energy distribution (SED). We discuss the physical implications of the contemporaneous light curves as well as the SED, in terms of synchrotron, synchrotron self-Compton and external Compton emission processes.Comment: 30 pages, 5 figures, accepted for publication in AS

Evidence for X-ray synchrotron emission from simultaneous mid-IR to X-ray observations of a strong Sgr A* flare

This paper reports measurements of Sgr A* made with NACO in L' -band (3.80 um), Ks-band (2.12 um) and H-band (1.66 um) and with VISIR in N-band (11.88 um) at the ESO VLT, as well as with XMM-Newton at X-ray (2-10 keV) wavelengths. On 4 April, 2007, a very bright flare was observed from Sgr A* simultaneously at L'-band and X-ray wavelengths. No emission was detected using VISIR. The resulting SED has a blue slope (beta > 0 for nuL_nu ~ nu^beta, consistent with nuL_nu ~ nu^0.4) between 12 micron and 3.8 micron. For the first time our high quality data allow a detailed comparison of infrared and X-ray light curves with a resolution of a few minutes. The IR and X-ray flares are simultaneous to within 3 minutes. However the IR flare lasts significantly longer than the X-ray flare (both before and after the X-ray peak) and prominent substructures in the 3.8 micron light curve are clearly not seen in the X-ray data. From the shortest timescale variations in the L'-band lightcurve we find that the flaring region must be no more than 1.2 R_S in size. The high X-ray to infrared flux ratio, blue nuL_nu slope MIR to L' -band, and the soft nuL_nu spectral index of the X-ray flare together place strong constraints on possible flare emission mechanisms. We find that it is quantitatively difficult to explain this bright X-ray flare with inverse Compton processes. A synchrotron emission scenario from an electron distribution with a cooling break is a more viable scenario.Comment: ApJ, 49 pages, 9 figure

Apparition d’anticorps anti-brucelliques après emploi d’une seringue ayant contenu du vaccin B 19

Dans cette expérimentation 6 jeunes bovins et 6 moutons indemnes de brucellose reçoivent du vaccin anti-aphteux à l’aide d’une seringue ayant contenu du vaccin B 19. On constate alors l’apparition d’agglutinines anti-brucelliques à des taux pouvant dépasser 240 Ul/ml chez certains animaux dès le quinzième jour après l’injection et susceptibles de persister encore au trentième jour. Cette formation d’anticorps est liée à la présence de Brucella résiduelles dans la seringue. L’épreuve au mercaptoéthanol confirme leur origine vaccinale. Ces résultats sont en accord avec ceux de Ch. Pilet, G. Beck et G. A. Cullen. C’est pourquoi on ne saurait apporter trop de soins au nettoyage des seringues ayant contenu du vaccin B 19 lorsque l’on doit les employer pour un autre usage

Prescribing indicators at primary health care centers within the WHO African region: a systematic analysis (1995-2015)

Abstract Background Rational medicine use is essential to optimize quality of healthcare delivery and resource utilization. We aim to conduct a systematic review of changes in prescribing patterns in the WHO African region and comparison with WHO indicators in two time periods 1995–2005 and 2006–2015. Methods Systematic searches were conducted in PubMed, Scopus, Web of science, Africa-Wide Nipad, Africa Journals Online (AJOL), Google scholar and International Network for Rational Use of Drugs (INRUD) Bibliography databases to identify primary studies reporting prescribing indicators at primary healthcare centres (PHCs) in Africa. This was supplemented by a manual search of retrieved references. We assessed the quality of studies using a 14-point scoring system modified from the Downs and Black checklist with inclusions of recommendations in the WHO guidelines. Results Forty-three studies conducted in 11 African countries were included in the overall analysis. These studies presented prescribing indicators based on a total 141,323 patient encounters across 572 primary care facilities. The results of prescribing indicators were determined as follows; average number of medicines prescribed per patient encounter = 3.1 (IQR 2.3–4.8), percentage of medicines prescribed by generic name =68.0 % (IQR 55.4–80.3), Percentage of encounters with antibiotic prescribed =46.8 % (IQR 33.7–62.8), percentage of encounters with injection prescribed =25.0 % (IQR 18.7–39.5) and the percentage of medicines prescribed from essential medicines list =88.0 % (IQR 76.3–94.1). Prescribing indicators were generally worse in private compared with public facilities. Analysis of prescribing across two time points 1995–2005 and 2006–2015 showed no consistent trends. Conclusions Prescribing indicators for the African region deviate significantly from the WHO reference targets. Increased collaborative efforts are urgently needed to improve medicine prescribing practices in Africa with the aim of enhancing the optimal utilization of scarce resources and averting negative health consequences