Effects of Alzheimer’s Disease on Visual Target Detection: A “Peripheral Bias”

Visual exploration is an omnipresent activity in everyday life, and might represent an important determinant of visual attention deficits in patients with Alzheimer’s Disease (AD). The present study aimed at investigating visual search performance in AD patients, in particular target detection in the far periphery, in daily living scenes. Eighteen AD patients and 20 healthy controls participated in the study. They were asked to freely explore a hemispherical screen, covering ±90°, and to respond to targets presented at 10°, 30°, and 50° eccentricity, while their eye movements were recorded. Compared to healthy controls, AD patients recognized less targets appearing in the center. No difference was found in target detection in the periphery. This pattern was confirmed by the fixation distribution analysis. These results show a neglect for the central part of the visual field for AD patients and provide new insights by mean of a search task involving a larger field of view

Principales dispositivos tecnol?gicos que intervienen en el proceso de aprendizaje en los alumnos de grado d?cimo de la instituci?n educativa San Bernardo del municipio de Ibagu?

40 p. Recurso Electr?nicoEn este art?culo se presentan los resultados de una investigaci?n adelantada con estudiantes de d?cimo grado de la Instituci?n Educativa San Bernardo ubicada en la zona rural del municipio de Ibagu?. El objetivo era determinar si los dispositivos tecnol?gicos usados por alguno(as) estudiantes incid?an en su proceso de aprendizaje. El enfoque metodol?gico que se utiliz? fue de car?cter mixto; Desde una perspectiva cualitativa, se recurri? a la entrevista semiestructurada, observaciones a la poblaci?n seleccionada, y desde la cuantitativa, a la encuesta de tipo abierta; el muestreo es probabil?stico no intencional, con 20 estudiantes entre los 15 y 18 a?os. Tambi?n, participaron algunos docentes que orientan diferentes ?reas en este grado. En los resultados encontrados se evidencia que en la poblaci?n seleccionada la mayor?a de los estudiantes hacen uso de los dispositivos tecnol?gicos en horas de clase; Adem?s, el manejo que le hacen a estos equipos es de forma inapropiada en (Redes sociales, juegos, chat y llamadas) causando distracci?n en sus actividades acad?micas. La investigaci?n permiti? concluir que son m?ltiples los factores que inducen a los estudiantes a utilizar tales dispositivos en el aula de clase; entre ellos, el poco inter?s de los estudiante por los aprendizajes te?ricos, la escasa motivaci?n por parte del docente al momento de desarrollar sus clases dado que privilegia las clases magistrales, por su parte, los docentes expresan el precario inter?s de los estudiante por formarse acad?micamente.In this article shows the results of an advanced research with 10 grade high school from San Bernardo educational institution of Ibagu? (Instituci?n eductiva San Bernardo del municipio de Ibagu?). The main goal was to determine if technological devices used for some students would influence in their learning process. The methodological focus that was used is about mixed character; from a qualitative perspective, it is used to half-estructured interview, observations to the target population from this research, and since the cuantitative character one, to the open type survey; the sampling is probabilistic sampling is unintentional, with a population of 20 students between 15 and 18 years old. In other hand, some teachers have been population participant who lead different subjects in that grade of high school. In the found results it may show that in the chosen populace the majority of students make use of technological devices in time class; In addition, the usages which make to those devices is in an inappropriate way in social media, games, chat and calls causing distraction in their academic activities. Keywords: Technological devices, learning process, school performance

Lava flow morphology at an erupting andesitic stratovolcano: a satellite perspective on El Reventador, Ecuador

Lava flows pose a significant hazard to infrastructure and property located close to volcanoes, and understanding how flows advance is necessary to manage volcanic hazard during eruptions. Compared to low-silica basaltic flows, flows of andesite composition are infrequently erupted and so relatively few studies of their characteristics and behaviour exist. We use El Reventador, Ecuador as a target to investigate andesitic lava flow properties during a 4.5 year period of extrusive eruption between February 2012 and August 2016. We use satellite radar to map the dimensions of 43 lava flows and look at variations in their emplacement behaviour over time. We find that flows descend the north and south flanks of El Reventador, and were mostly emplaced during durations shorter than the satellite repeat interval of 24 days.Flows ranged in length from 0.3 to 1.7 km, and the length of these flows decreased over the observation period. We measure a decrease in flow volume with time that is correlated with a long-term exponential decrease in eruption rate, and propose that this behaviour is caused by temporary magma storage in the conduit acting as a melt capacitor between the magma reservoir and the surface. We use the dimensions of the flow levees and widths to estimate the flow yield strengths, which were of the order of 10-100 kPa. We observe that some flows were diverted by topographic obstacles, and compare measurements of decreased channel width and increased flow thickness at the obstacles with observations from laboratory experiments. Radar observations, such as those presented here, could be used to map and measure properties of evolving lava flow fields at other remote or difficult to monitor volcanoes

La Pileta (Benaoján, Málaga) cien años después. Aportaciones al conocimiento de su secuencia arqueológica

La cueva de La Pileta es un yacimiento muy conocido por la riqueza de las manifestaciones artísticas parietales prehistóricas que atesora. Sin embargo, el conocimiento de la secuencia cronocultural documentada en las excavaciones arqueológicas llevadas a cabo en 1912 y 1942 es muy pobre. En este trabajo hacemos un repaso del registro arqueológico de La Pileta a partir de la revisión historiográfica y del estudio de los materiales depositados en el Museo de Málaga y de algunos documentos del archivo de esta institución. Los resultados, aunque limitados, permiten deducir la existencia de una secuencia más amplia de la conocida por lo general, compuesta por niveles del Paleolítico medio, Paleolítico superior; Neolítico, Calcolítico, Edad del Bronce y Edad Media

Overexpression of caveolin-1 results in increased plasma membrane trageting of phosphofructokinase: The structural basis for a membrane associated metabolic compartment

Abstract only availablePrevious work from our laboratory has shown that glycolysis and gluconeogenesis occur in separate compartments within the vascular smooth muscle cell ( VSM ) and that their intermediates do not mix freely in the cytoplasm. We have previously found that the glycolytic -specific enzyme phosphofructokinase ( PFK ) appeared to colocalize with the fairly ubiquitous plasma membrane protein caveolin -1 ( CAV - 1 ), consistent with a role for CAV - 1 as an anchor for glycolysis to the plasma membrane. We hypothesized that CAV - 1 serves as a scaffolding protein for PFK and may play a role for the organization of cell metabolism. To test this hypothesis , we over -expressed the CAV - 1 gene in cultured A7r5 ( rat aorta VSM ) cells by transfection with a CAV - 1 coding plasmid. Immunoflorescence and confocal microscopy were used to study the distribution of PFK and CAV - 1 in the transfected cells. Areas of Interest ( AOI ) were analyzed in a central z -plane across the cell transvesing the perinuclear region. To quantify any shift in PFK localization resulting from CAV - 1 over -expression , we calculated a periphery to center ( PC ) index by taking the average of the two outer AOIs from each membrane region and dividing by the central one or two AOIs. We found that the PC was 2. 2 5 + / - 0. 8 5 ( mean + / - SEM, N = 5 ) for transfected cells and was 0. 4 7 + / - 0. 1 6 for control cells. These results demonstrate that CAV - 1 creates binding sites for PFK that may be of higher affinity than those localized in the cytoplasm ( such as microtubules and the actin cytoskeleton ). We therefore conclude that CAV - 1 functions as a scaffolding protein for PFK and that this may contribute to the elucidation of the basis for carbohydrate compartmentation to the plasma membrane in VSM. Support provided by NIH 60668 (to Christopher D. Hardin) and Life Sciences Undergraduate Research Opportunity Program (LS UROP).Life Sciences Undergraduate Research Opportunity Progra

First results in the study of the morphology present status of the andalusian black cattle breed

Andalusian Black cattle breed is in danger of extinction alter to go out of the border of the disappearance. Moreover, the present situation of the Spanish farming, its belonging to the Iberian Black branch, producing a high pressure from other related breeds with a better productive potentiality. Studies for the breed conservation have begun, among them, the morphological study. By the moment 3 different farms without known influences from other breeds and 24 adult females have been recorded for 14 quantitative morphological traits, and some qualitative such as front profile and coat colour. Studied individuals presented few morphological variation and it put the breed near of the breed morphological pattern updating.La raza Negra Andaluza se encuentra en peligro de extinción tras haber estado al borde de la desaparición. Además de la actual situación de la ganadería española, a lo anterior ha contribuido su pertenencia al tronco Negro Ibérico, y la gran presión que razas con un potencial más desarrollado han ejercido sobre ésta. Se han comenzado los estudios necesarios para la conservación de este recurso genético, entre ellos, el estudio morfológico. Hasta el momento se han estudiado 3 ganaderías diferentes sin influencia genética de otras razas y un total de 24 hembras adultas en las que se han tomado 14 medidas morfológicas. Además se han observado variables cualitativas, como el perfil y la capa. Los individuos estudiados presentan poca variación morfológica entre ellos y, por tanto, acercan a la actualización del patrón morfológico de la raza

Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.

N-acetyltransferase 2 (NAT2), an important enzyme in clinical pharmacology, metabolizes antibiotics such as isoniazid and sulfamethoxazole, and catalyzes the transformation of aromatic and heterocyclic amines from the environment and diet into carcinogenic intermediates. Polymorphisms in NAT2 account for variability in the acetylator phenotype and the pharmacokinetics of metabolized drugs. Native Americans, settled in rural areas and large cities of Latin America, are under-represented in pharmacogenetics studies; therefore, we sequenced the coding region of NAT2 in 456 chromosomes from 13 populations from the Americas, and two from Siberia, detecting nine substitutions and 11 haplotypes. Variants *4 (37%), *5B (23%) and *7B (24%) showed high frequencies. Average frequencies of fast, intermediate and slow acetylators across Native Americans were 18, 56 and 25%, respectively. NAT2 intra-population genetic diversity for Native Americans is higher than East Asians and similar to the rest of the world, and NAT2 variants are homogeneously distributed across native populations of the continent

Trending in Probability of Collision Measurements

A simple model is proposed to predict the behavior of Probabilities of Collision (P(sub c)) for conjunction events. The model attempts to predict the location and magnitude of the peak P(sub c) value for an event by assuming the progression of P(sub c) values can be modeled to first order by a downward-opening parabola. To incorporate prior information from a large database of past conjunctions, the Bayes paradigm is utilized; and the operating characteristics of the model are established through a large simulation study. Though the model is simple, it performs well in predicting the temporal location of the peak (P(sub c)) and thus shows promise as a decision aid in operational conjunction assessment risk analysis