Self-administration of methohexital, midazolam and ethanol: effects on the pituitary–adrenal axis in rhesus monkeys

There is disagreement in the literature with respect to how drugs of abuse affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis, and whether these changes in endocrine function may be related to the rewarding effects of these drugs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46363/1/213_2004_Article_1986.pd

ELM and ELM-control Simulations

In recent years, increased HPC resources and performance has enabled significant advances in the quality and reliability of non-linear MHD simulations of tokamak instabilities. In the domain of Edge-Localised-Modes, validation of the JOREK code has been achieved by addressing various characteristics of this instability. The necessity to control ELMs, in order to reduce divertor heat-fluxes in ITER, while maximising the flushing of high-Z impurities, motivates a thorough validation of the numerical and physical model, so that reliable predictions can be provided for future devices. With increasing concordance between simulation results and experimental observations, non-linear MHD is starting to provide insight into several open questions about ELM physics and ELM-control techniques, in time for the development and exploitation of ITER operation