Clinical submission of supernumerary head of adducter brevis muscle

Adductor brevis is an important member of the adductor family occupying the medial compartment of the thigh executing the function of adduction and medial rotation. Deviations from normal anatomy are unusual and rarely reported. A survey of anatomical archives revealed occasional mention of additional bellies of adductor brevis muscle. The present study reports a double belly of adductor brevis muscle (AB) found during a cadaveric dissection class for medical students. The left sided AB displayed two bellies disposed in the same plane. This case report attempts to present the clinical applications of supernumerary bellies of this important adductor muscle of the thigh. It is feasible to categorize these muscular variations upon specialized radiological procedures such as CT and MRI scans only if the radiologist possesses satisfactory understanding of variant anatomy of this region. It is thereafter inferred that upon recognition these muscles present a fair chance of being of utilitised in reconstructions. A biomechanical overview of the present anomaly is also attempte

Airborne coherent continuous wave CO2 Doppler lidars for aerosol backscatter measurement

Two focused coherent, continuous wave (CW) lidars have been developed by the Marshall Space Flight Center (MSFC) for airborne and ground-based measurement of aerosol backscatter coefficients. The first of these instruments uses a mixture of CO2 and other gases, and measures backscatter at 10.6 m. The second lidar uses an isotope of carbon dioxide, which enables lasing at 9.1 m. The 10.6 m backscatter measurement serves as a reference to allow variations in backscatter due to aerosol concentration to be distinguished from variations due to spectral variability. The 10.6 m lidar has been used in airborne field programs since 1981. Development of the 9.1 m lidar was completed in early 1989. Recently, both lidars were flown on the NASA/Ames Research Center DC-8 research aircraft in the remote Pacific Basin as part of the NASA GLObal Backscatter Experiment (GLOBE) survey missions. The GLOBE program, of which the survey missions are the centerpieces, supports design and simulation studies for NASA's prospective Laser Atmospheric Wind Sounder (LAWS)

Phase-plane analysis of driven multi-lane exclusion models

We show how a fixed point based boundary-layer analysis technique can be used to obtain the steady-state particle density profiles of driven exclusion processes on two-lane systems with open boundaries. We have considered two distinct two-lane systems. In the first, particles hop on the lanes in one direction obeying exclusion principle and there is no exchange of particles between the lanes. The hopping on one lane is affected by the particle occupancies on the other, which thereby introduces an indirect interaction among the lanes. Through a phase plane analysis of the boundary layer equation, we show why the bulk density undergoes a sharp change as the interaction between the lanes is increased. The second system involves one lane with driven exclusion process and the other with biased diffusion of particles. In contrast to the previous model, here there is a direct interaction between the lanes due to particle exchange between them. In this model, we have looked at two possible scenarios with constant (flat) and non-constant bulk profiles. The fixed point based boundary layer method provides a new perspective on several aspects including those related to maximal/minimal current phases, possibilities of shocks under very restricted boundary conditions for the flat profile but over a wide range of boundary conditions for the non-constant profile.Comment: 13 pages, 17 figure

A Significant Population of Very Luminous Dust-Obscured Galaxies at Redshift z ~ 2

Observations with Spitzer Space Telescope have recently revealed a significant population of high-redshift z~2 dust-obscured galaxies (DOGs) with large mid-IR to UV luminosity ratios. These galaxies have been missed in traditional optical studies of the distant universe. We present a simple method for selecting this high-z population based solely on the ratio of the observed mid-IR 24um to optical R-band flux density. In the 8.6 sq.deg Bootes NDWFS Field, we uncover ~2,600 DOG candidates (= 0.089/sq.arcmin) with 24um flux densities F24>0.3mJy and (R-[24])>14 (i.e., F[24]/F[R] > 1000). These galaxies have no counterparts in the local universe, and become a larger fraction of the population at fainter F24, representing 13% of the sources at 0.3~mJy. DOGs exhibit evidence of both star-formation and AGN activity, with the brighter 24um sources being more AGN- dominated. We have measured spectroscopic redshifts for 86 DOGs, and find a broad z distribution centered at ~2.0. Their space density is 2.82E-5 per cubic Mpc, similar to that of bright sub-mm-selected galaxies at z~2. These redshifts imply very large luminosities LIR>~1E12-14 Lsun. DOGs contribute ~45-100% of the IR luminosity density contributed by all z~2 ULIRGs, suggesting that our simple selection criterion identifies the bulk of z~2 ULIRGs. DOGs may be the progenitors of ~4L* present-day galaxies seen undergoing a luminous,short- lived phase of bulge and black hole growth. They may represent a brief evolution phase between SMGs and less obscured quasars or galaxies. [Abridged]Comment: Accepted for publication in the Astrophysical Journa

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.

Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.PURPOSE: In spite of intense research efforts, pancreatic ductal adenocarcinoma remains one of the most deadly malignancies in the world. We and others have previously identified a subpopulation of pancreatic cancer stem cells within the tumor as a critical therapeutic target and additionally shown that the tumor stroma represents not only a restrictive barrier for successful drug delivery, but also serves as a paracrine niche for cancer stem cells. Therefore, we embarked on a large-scale investigation on the effects of combining chemotherapy, hedgehog pathway inhibition, and mTOR inhibition in a preclinical mouse model of pancreatic cancer. EXPERIMENTAL DESIGN: Prospective and randomized testing in a set of almost 200 subcutaneous and orthotopic implanted whole-tissue primary human tumor xenografts. RESULTS: The combined targeting of highly chemoresistant cancer stem cells as well as their more differentiated progenies, together with abrogation of the tumor microenvironment by targeting the stroma and enhancing tissue penetration of the chemotherapeutic agent translated into significantly prolonged survival in preclinical models of human pancreatic cancer. Most pronounced therapeutic effects were observed in gemcitabine-resistant patient-derived tumors. Intriguingly, the proposed triple therapy approach could be further enhanced by using a PEGylated formulation of gemcitabine, which significantly increased its bioavailability and tissue penetration, resulting in a further improved overall outcome. CONCLUSIONS: This multimodal therapeutic strategy should be further explored in the clinical setting as its success may eventually improve the poor prognosis of patients with pancreatic ductal adenocarcinoma

Competition between normal and intruder states inside the "Island of Inversion"

The beta decay of the exotic 30Ne (N=20) is reported. For the first time, the low-energy level structure of the N=19, 30Na (Tz = 4), is obtained from beta-delayed gamma spectroscopy using fragment-beta-gamma-gamma coincidences. The level structure clearly displays "inversion", i.e., intruder states with mainly 2p2h configurations displacing the normal states to higher excitation energies. The good agreement in excitation energies and the weak and electromagnetic decay patterns with Monte Carlo Shell Model calculations with the SDPF-M interaction in the sdpf valence space illustrates the small d3/2 - f7/2 shell gap. The relative position of the "normal dominant" and "intruder dominant" excited states provides valuable information to understand better the N=20 shell gap.Comment: 4 pages, 5 figure

Distribution of the color fields around static quarks: Flux tube profiles

We report detailed calculations of the profiles of energy and action densities in the quark-antiquark string in SU(2) lattice gauge theory.Comment: 40 pages, LSUHE 94-15