Flight and wind-tunnel comparisons of the inlet-airframe interaction of the F-15 airplane

The design of inlets and nozzles and their interactions with the airplane which may account for a large percentage of the total drag of modern high performance aircraft is discussed. The inlet/airframe interactions program and the flight tests conducted is described. Inlet drag and lift data from a 7.5% wind-tunnel model are compared with data from an F-15 airplane with instrumentation to match the model. Pressure coefficient variations with variable cowl angles, capture ratios, examples of flow interactions and angles of attack are for Mach numbers of 0.6, 0.9, 1.2, and 1.5 are presented

Airports at Risk: The Impact of Information Sources on Security Decisions

Security decisions in high risk organizations such as airports involve obtaining ongoing and frequent information about potential threats. Utilizing questionnaire survey data from a sample of airport employees in European Airports across the continent, we analyzed how both formal and informal sources of security information affect employee's decisions to comply with the security rules and directives. This led us to trace information network flows to assess its impact on the degree employees making security decisions comply or deviate with the prescribed security rules. The results of the multivariate analysis showed that security information obtained through formal and informal networks differentially determine if employee will comply or not with the rules. Information sources emanating from the informal network tends to encourage employees to be more flexible in their security decisions while formal sources lead to be more rigid with complying with rules and protocols. These results suggest that alongside the formal administrative structure of airports, there exists a diverse and pervasiveness set of informal communications networks that are a potent factor in determining airport security levels

Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site

We introduce a novel method to screen the promoters of a set of genes with shared biological function, against a precompiled library of motifs, and find those motifs which are statistically over-represented in the gene set. The gene sets were obtained from the functional Gene Ontology (GO) classification; for each set and motif we optimized the sequence similarity score threshold, independently for every location window (measured with respect to the TSS), taking into account the location dependent nucleotide heterogeneity along the promoters of the target genes. We performed a high throughput analysis, searching the promoters (from 200bp downstream to 1000bp upstream the TSS), of more than 8000 human and 23,000 mouse genes, for 134 functional Gene Ontology classes and for 412 known DNA motifs. When combined with binding site and location conservation between human and mouse, the method identifies with high probability functional binding sites that regulate groups of biologically related genes. We found many location-sensitive functional binding events and showed that they clustered close to the TSS. Our method and findings were put to several experimental tests. By allowing a "flexible" threshold and combining our functional class and location specific search method with conservation between human and mouse, we are able to identify reliably functional TF binding sites. This is an essential step towards constructing regulatory networks and elucidating the design principles that govern transcriptional regulation of expression. The promoter region proximal to the TSS appears to be of central importance for regulation of transcription in human and mouse, just as it is in bacteria and yeast.Comment: 31 pages, including Supplementary Information and figure

Prompt, early, and afterglow optical observations of five gamma-ray bursts (GRBs 100901A, 100902A, 100905A, 100906A, and 101020A)

We present results of the prompt, early, and afterglow optical observations of five gamma-ray bursts, GRBs 100901A, 100902A, 100905A, 100906A, and 101020A, made with the Mobile Astronomical System of TElescope-Robots in Russia (MASTER-II net), the 1.5-m telescope of Sierra-Nevada Observatory, and the 2.56-m Nordic Optical Telescope. For two sources, GRB 100901A and GRB 100906A, we detected optical counterparts and obtained light curves starting before cessation of gamma-ray emission, at 113 s and 48 s after the trigger, respectively. Observations of GRB 100906A were conducted with two polarizing filters. Observations of the other three bursts gave the upper limits on the optical flux; their properties are briefly discussed. More detailed analysis of GRB 100901A and GRB 100906A supplemented by Swift data provides the following results and indicates different origins of the prompt optical radiation in the two bursts. The light curves patterns and spectral distributions suggest a common production site of the prompt optical and high-energy emission in GRB 100901A. Results of spectral fits for GRB 100901A in the range from the optical to X-rays favor power-law energy distributions with similar values of the optical extinction in the host galaxy. GRB 100906A produced a smoothly peaking optical light curve suggesting that the prompt optical radiation in this GRB originated in a front shock. This is supported by a spectral analysis. We have found that the Amati and Ghirlanda relations are satisfied for GRB 100906A. An upper limit on the value of the optical extinction on the host of GRB 100906A is obtained.Comment: 18 pages, 14 figures, 14 tables, 5 machine readable tables; accepted for publication in MNRA

Towards a strategy for the recovering of the Mediterranean monk seal in the Adriatic-Ionian Basin

Occasional but recurrent sightings indicate that the endangered Mediterranean monk seal is still present in most of its historical range within the Adriatic-Ionian region in the central Mediterranean Sea. However, in most of the adjacent countries, the species' abundance and distribution are practically unknown. An actively reproducing sub-population with a minimum of 25 adult/sub-adult seals lives in the Greek central Ionian Sea. The latter can form a nucleus from which the entire Adriatic-Ionian Basin could be re-colonized if adequate conservation measures are implemented throughout the area and in a coordinated manner. We examine the historical presence in the region as a baseline for providing a benchmark for conservation. We further look into the species' habitat availability, possibilities for a rapid population assessment and various parameters that are considered crucial for its conservation, such as the existence of Marine Protected Areas (MPAs), corridors for connectivity purposes as well as needs for raising public awareness. We recommend a series of interlinked actions within the framework of a conservation strategy the implementation of which will ensure the conditions for maintaining ecologically, demographically, and genetically viable sub-populations of this species emblematic for the entire Mediterranean Sea. To achieve this goal, a coalition of partners from this area is required in order to adopt the strategy and jointly implement the measures required

Social Participation and Disaster Risk Reduction Behaviors in Tsunami Prone Areas

This paper examines the relationships between social participation and disaster risk reduction actions. A survey of 557 households in tsunami prone areas in Phang Nga, Thailand was conducted following the 2012 Indian Ocean earthquakes. We use a multivariate probit model to jointly estimate the likelihood of undertaking three responses to earthquake and tsunami hazards (namely, (1) following disaster-related news closely, (2) preparing emergency kits and/or having a family emergency plan, and (3) having an intention to migrate) and community participation.We find that those who experienced losses from the 2004 tsunami are more likely to participate in community activities and respond to earthquake hazards. Compared to men, women are more likely to prepare emergency kits and/or have an emergency plan and have a greater intention to migrate. Living in a community with a higher proportion of women with tertiary education increases the probability of engaging in community activities and carrying out disaster risk reduction measures. Individuals who participate in village-based activities are 5.2% more likely to undertake all three risk reduction actions compared to those not engaging in community activities. This implies that encouraging participation in community activities can have positive externalities in disaster mitigation

Genome-wide association study of Tourette Syndrome

Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel, and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (p<5 × 10−8); the top signal was found in rs7868992 on chromosome 9q32 within COL27A1 (p=1.85 × 10−6). A secondary analysis including an additional 211 cases and 285 controls from two closely-related Latin-American population isolates from the Central Valley of Costa Rica and Antioquia, Colombia also identified rs7868992 as the top signal (p=3.6 × 10−7 for the combined sample of 1496 cases and 5249 controls following imputation with 1000 Genomes data). This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder

Morbidity and Mortality After Benign Prostatic Hyperplasia Surgery: Data from the American College of Surgeons National Surgical Quality Improvement Program

Background and Purpose: With the aging population, it is becoming increasingly important to identify patients at risk for postsurgical complications who might be more suited for conservative treatment. We sought to identify predictors of morbidity after surgical treatment of benign prostatic hyperplasia (BPH) using a large national contemporary population-based cohort. Methods: Relying on the American College of Surgeons National Surgical-Quality Improvement Program (ACS-NSQIP; 2006?2011) database, we evaluated outcomes after transurethral resection of the prostate (TURP), laser vaporization of the prostate (LVP), and laser enucleation of the prostate (LEP). Outcomes included blood-transfusion rates, length of stay, complications, reintervention rates, and perioperative mortality. Multivariable logistic-regression analysis evaluated the predictors of perioperative morbidity and mortality. Results: Overall, 4794 (65.2%), 2439 (33.1%), and 126 (1.7%) patients underwent TURP, LVP, and LEP, respectively. No significant difference in overall complications (P=0.3) or perioperative mortality (P=0.5) between the three surgical groups was found. LVP was found to be associated with decreased blood transfusions (odds ratio [OR]=0.21; P=0.001), length of stay (OR=0.12; P30%) levels were the only predictors of lower overall complications and perioperative mortality. Conclusions: All three surgical modalities for BPH management were found to be safe. Advanced age and non-Caucasian race were independent predictors of adverse outcomes after BPH surgery. In patients with these attributes, conservative treatment might be a reasonable alternative. Also, preoperative hematocrit and albumin levels represent reliable predictors of adverse outcomes, suggesting that these markers should be evaluated before BPH surgery.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140378/1/end.2013.0805.pd