Study of the performance of a large scale water-Cherenkov detector (MEMPHYS)

MEMPHYS (MEgaton Mass PHYSics) is a proposed large-scale water Cherenkov experiment to be performed deep underground. It is dedicated to nucleon decay searches, neutrinos from supernovae, solar and atmospheric neutrinos, as well as neutrinos from a future Super-Beam or Beta-Beam to measure the CP violating phase in the leptonic sector and the mass hierarchy. A full simulation of the detector has been performed to evaluate its performance for beam physics. The results are given in terms of "Migration Matrices" of reconstructed versus true neutrino energy, taking into account all the experimental effects.Comment: Updated after JCAP's referee's comment

Future large-scale water-Cherenkov detector

MEMPHYS (MEgaton Mass PHYSics) is a proposed large-scale water-Cherenkov experiment to be performed deep underground. It is dedicated to nucleon decay searches and the detection of neutrinos from supernovae, solar, and atmospheric neutrinos, as well as neutrinos from a future beam to measure the CP violating phase in the leptonic sector and the mass hierarchy. This paper provides an overview of the latest studies on the expected performance of MEMPHYS in view of detailed estimates of its physics reach, mainly concerning neutrino beams

Motor neurone and muscle nuclear changes in development and disease

The primary gene defects of hereditary neuromuscular disorders have not, as yet, been determined. Research has contributed much to our understanding of many aspects of these diseases, but since this has been directed towards the secondary phenomena, the exact role of the nucleus in the pathogenesis of these genetic disorders remains unclear. It was felt that a study of the motor neurone and muscle nucleus in development and disease might reveal the extent of its participation in some of these disease processes. 1. A quantitative histochemical and histometric study of the developing anterior horn cell nucleus during fetal life was undertaken. The result suggested that the 12th to 14th week period is critical for the differentiation of the spinal motor neurone. 2. In contrast to this, a similar study of the deve¬ loping muscle cell nuclei revealed no major changes in muscle nuclear size or composition. During normal post-natal muscle growth an increase in the number of nuclei per muscle fibre seems to be responsible for the maintenance of a constant nucleo-cytoplasmic ratio. 3. The nuclear size of multinucleated myoblasts arising from both normal and dystrophic muscle in tissue culture was measured. Myoblasts from dystrophic muscle exhibited larger nuclei than those from normal muscle. 4. An increase in muscle nuclear size was also detected in a number of muscle samples from male fetuses at risk for Duchenne muscular dystrophy. Both of these findings suggest possible changes in the nucleo-cytoplasmic relationship. 5. In an attempt to elucidate the extent of the parti¬ cipation of the muscle nucleus in the pathogenic process of a number of characteristic neuromuscular disorders, the nuclear size and/or the number of nuclei per cross-sectioned muscle fibre, were estimated. An increased nuclear size was observed in Duchenne muscular dystrophy and an increase in the number of nuclei was detected in chronic neurogenic atrophies, in diabetic neuropathy and in myotonic dystrophy. Such a finding would seem to indicate a fundamental difference in the response of the muscle fibre nucleus to the neurogenic and myopathic processes. 6. In addition, the growth of the human cervical vertebral canal and spinal cord during normal fetal development was studied. The results suggested that these two parts of the developing body exhibit the same developmental pattern. The rate of this parallel growth is lower than that of the body as a whole, but similar to that reported for the brain. In conclusion, although the techniques used did not reveal a direct relationship in the developmental pattern of anterior horn cell nuclei and myonuclei, they did provide normal values for comparison with data obtained from diseased neural and muscle tissue. The finding that in Duchenne muscular dystrophy (from tissue culture, fetuses at risk and juvenile biopsies) the muscle nuclei are enlarged, points to an underlying difference from various neuropathies in which the nuclei are increased in number

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function

Clathrins are cytoplasmic proteins that play essential roles in endocytosis and other membrane traffic pathways. Upon recruitment to intracellular membranes, the canonical clathrin triskelion assembles into a polyhedral protein coat that facilitates vesicle formation and captures cargo molecules for transport. The triskelion is formed by trimerization of three clathrin heavy-chain subunits. Most vertebrates have two isoforms of clathrin heavy chains, CHC17 and CHC22, generating two clathrins with distinct cellular functions. CHC17 forms vesicles at the plasma membrane for receptor-mediated endocytosis and at the trans-Golgi network for organelle biogenesis. CHC22 plays a key role in intracellular targeting of the insulin-regulated glucose transporter 4 (GLUT4), accumulates at the site of GLUT4 sequestration during insulin resistance, and has also been implicated in neuronal development. Here, we demonstrate that CHC22 and CHC17 share morphological features, in that CHC22 forms a triskelion and latticed vesicle coats. However, cellular CHC22-coated vesicles were distinct from those formed by CHC17. The CHC22 coat was more stable to pH change and was not removed by the enzyme complex that disassembles the CHC17 coat. Moreover, the two clathrins were differentially recruited to membranes by adaptors, and CHC22 did not support vesicle formation or transferrin endocytosis at the plasma membrane in the presence or absence of CHC17. Our findings provide biochemical evidence for separate regulation and distinct functional niches for CHC17 and CHC22 in human cells. Furthermore, the greater stability of the CHC22 coat relative to the CHC17 coat may be relevant to its excessive accumulation with GLUT4 during insulin resistance. [Abstract copyright: Copyright © 2017, The American Society for Biochemistry and Molecular Biology.

Search for composite and exotic fermions at LEP 2

A search for unstable heavy fermions with the DELPHI detector at LEP is reported. Sequential and non-canonical leptons, as well as excited leptons and quarks, are considered. The data analysed correspond to an integrated luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172 GeV and 161 GeV. The search for pair-produced new leptons establishes 95% confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2, depending on the channel. The search for singly produced excited leptons and quarks establishes upper limits on the ratio of the coupling of the excited fermio

High intensity neutrino oscillation facilities in Europe

The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fréjus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of μ+ and μ− beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He6 and Ne18, also stored in a ring. The far detector is also the MEMPHYS detector in the Fréjus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive

Search for lightest neutralino and stau pair production in light gravitino scenarios with stau NLSP

Promptly decaying lightest neutralinos and long-lived staus are searched for in the context of light gravitino scenarios. It is assumed that the stau is the next to lightest supersymmetric particle (NLSP) and that the lightest neutralino is the next to NLSP (NNLSP). Data collected with the Delphi detector at centre-of-mass energies from 161 to 183 \GeV are analysed. No evidence of the production of these particles is found. Hence, lower mass limits for both kinds of particles are set at 95% C.L.. The mass of gaugino-like neutralinos is found to be greater than 71.5 GeV/c^2. In the search for long-lived stau, masses less than 70.0 to 77.5 \GeVcc are excluded for gravitino masses from 10 to 150 \eVcc . Combining this search with the searches for stable heavy leptons and Minimal Supersymmetric Standard Model staus a lower limit of 68.5 \GeVcc may be set for the stau mas

Neutrinos from Stored Muons nuSTORM: Expression of Interest

The nuSTORM facility has been designed to deliver beams of electron and muon neutrinos from the decay of a stored muon beam with a central momentum of 3.8 GeV/c and a momentum spread of 10%. The facility is unique in that it will: serve the future long- and short-baseline neutrino-oscillation programmes by providing definitive measurements of electron-neutrino- and muon-neutrino-nucleus cross sections with percent-level precision; allow searches for sterile neutrinos of exquisite sensitivity to be carried out; and constitute the essential first step in the incremental development of muon accelerators as a powerful new technique for particle physics. Of the world's proton-accelerator laboratories, only CERN and FNAL have the infrastructure required to mount nuSTORM. Since no siting decision has yet been taken, the purpose of this Expression of Interest (EoI) is to request the resources required to: investigate in detail how nuSTORM could be implemented at CERN; and develop options for decisive European contributions to the nuSTORM facility and experimental programme wherever the facility is sited. The EoI defines a two-year programme culminating in the delivery of a Technical Design Report

Search for Neutral Heavy Leptons Produced in Z Decays

Weak isosinglet Neutral Heavy Leptons ($\nu_m$) have been searched for using data collected by the DELPHI detector corresponding to $3.3\times 10^{6}$ hadronic~Z$^{0}$ decays at LEP1. Four separate searches have been performed, for short-lived $\nu_m$ production giving monojet or acollinear jet topologies, and for long-lived $\nu_m$ giving detectable secondary vertices or calorimeter clusters. No indication of the existence of these particles has been found, leading to an upper limit for the branching ratio $BR($Z$^0\rightarrow \nu_m \overline{\nu})$ of about $1.3\times10^{-6}$ at 95\% confidence level for $\nu_m$ masses between 3.5 and 50 GeV/$c^2$. Outside this range the limit weakens rapidly with the $\nu_m$ mass. %Special emphasis has been given to the search for monojet--like topologies. One event %has passed the selection, in agreement with the expectation from the reaction: %$e^+e^- \rightarrow\ell \bar\ell \nu\bar\nu$. The results are also interpreted in terms of limits for the single production of excited neutrinos