Development of an integrated cognitive behavioral therapy for anxiety and opioid use disorder: Study protocol and methods

Opioid use disorder is a highly disabling psychiatric disorder, and is associated with both significant functional disruption and risk for negative health outcomes such as infectious disease and fatal overdose. Even among those who receive evidence-based pharmacotherapy for opioid use disorder, many drop out of treatment or relapse, highlighting the importance of novel treatment strategies for this population. Over 60% of those with opioid use disorder also meet diagnostic criteria for an anxiety disorder; however, efficacious treatments for this common co-occurrence have not be established. This manuscript describes the rationale and methods for a behavioral treatment development study designed to develop and test an integrated cognitive-behavioral therapy for those with co-occurring opioid use disorder and anxiety disorders. The aims of the study are (1) to develop and pilot test a new manualized cognitive behavioral therapy for co-occurring opioid use disorder and anxiety disorders, (2) to test the efficacy of this treatment relative to an active comparison treatment that targets opioid use disorder alone, and (3) to investigate the role of stress reactivity in both prognosis and recovery from opioid use disorder and anxiety disorders. Our overarching aim is to investigate whether this new treatment improves both anxiety and opioid use disorder outcomes relative to standard treatment. Identifying optimal treatment strategies for this population are needed to improve outcomes among those with this highly disabling and life-threatening disorder.This study was funded by NIDA grant DA035297. The funding source had no involvement in the study design, analysis and interpretation of data, writing of the report, or the decision to submit the article for publication. (DA035297 - NIDA)Accepted manuscrip

The detailed method of optimal regions

The detailed method of optimal regions is an extended form of the method of optimal regions which has been found effective in solving the personnel classification problem when the number of job categories is small. The automatic determination of the successive values of the v i , made possible by the more exact techniques of the detailed method, provide easier solutions for the more complex problems and provide solutions, which, for the most part, can be mechanized. In a sense the detailed method of optimal regions is more than a detailed form of the method of optimal regions. It is essentially a method of transformations by which the original matrix is reduced to a matrix from which the solution is easily obtained.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45700/1/11336_2005_Article_BF02289208.pd

Overview of charged-particle beam diagnostics for the Advanced Photon Source (APS)

Plans, prototypes, and initial test results for the charged-particle beam (e[sup [minus]],e[sup +]) diagnostic systems on the injector rings, their transport lines, and the storage ring for the Advanced Photon Source (APS) are presented. The APS will be a synchrotron radiation user facility with one of the world's brightest x-ray sources in the 10-keV to 100-keV regime. Its 200-MeV electron linac, 450-MeV positron linac, positron accumulator ring, 7-GeV booster synchrotron, 7-GeV storage ring, and undulator test lines will also demand the development and demonstration of key particle-beam characterization techniques over a wide range of parameter space. Some of these parameter values overlap or approach those projected for fourth generation light sources (linac-driven FELs and high brightness storage rings) as described at a recent workshop. Initial results from the diagnostics prototypes on the linac test stand operating at 45-MeV include current monitor data, beam loss monitor data, and video digitization using VME architecture

The mean and standard deviation of the distribution of group assembly sums

An interesting problem in linear programming is the group assembly problem which is mathematically equivalent to the general transportation problem of economics. Computer programs designed for the determination of exact and approximate optimal group assemblies have been available for some time. This paper presents formulas for the mean and squared standard deviation of the distribution of all possible group assembly sums. Computational techniques are presented and the results are related to those of the analysis of variance of a k -factor problem with n levels of each factor.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45717/1/11336_2005_Article_BF02289606.pd

CSR: Evolution of concept

Corporate social responsibility (CSR) can be defined as a “concept whereby companies decide voluntarily to contribute to a better society and a cleaner environment” (European Commission 2001, p. 4). The basic notion of CSR “is the idea that it reflects the social imperatives and the social consequences of business success” (Matten and Moon 2008, p. 405). In that sense, the European Commission presented a new definition of CSR as “the responsibility of enterprises for their impacts on society” (European Commission 2011, p. 7). The Communication of the European Commission at the end of 2011 underpinned the adverse effects of the economic and social crisis, as they have damaged consumer confidence and levels of trust in business and “have focused public attention on the social and ethical performance of enterprises” (European Commission 2011, p. 5). CSR is an umbrella term overlapping with some and being...info:eu-repo/semantics/acceptedVersio

Cross-Section Measurement of Virtual Photoproduction of Iso-Triplet Three-Body Hypernucleus, ⋀nn

Missing-mass spectroscopy with the 3H(e, e′K+) reaction was carried out at Jefferson Lab’s (JLab) Hall A in Oct–Nov, 2018. The differential cross section for the 3H(γ∗, K+)Λnn was deduced at ω = Ee − Ee′ = 2.102 GeV and at the forward K+-scattering angle (0° ≤ θγ∗K ≤ 5°) in the laboratory frame. Given typical predicted energies and decay widths, which are (BΛ, Γ) = (−0.25, 0.8) and (−0.55, 4.7) MeV, the cross sections were found to be 11.2 ± 4.8(stat.)+4.1−2.1(sys.) and 18.1 ± 6.8(stat.)+4.2−2.9(sys.) nb/sr, respectively. The obtained result would impose a constraint for interaction models particularly between Λ and neutron by comparing to theoretical calculations

A novel measurement of the neutron magnetic form factor from A=3 mirror nuclei

The electromagnetic form factors of the proton and neutron encode information on the spatial structure of their charge and magnetization distributions. While measurements of the proton are relatively straightforward, the lack of a free neutron target makes measurements of the neutron's electromagnetic structure more challenging and more sensitive to experimental or model-dependent uncertainties. Various experiments have attempted to extract the neutron form factors from scattering from the neutron in deuterium, with different techniques providing different, and sometimes large, systematic uncertainties. We present results from a novel measurement of the neutron magnetic form factor using quasielastic scattering from the mirror nuclei $^3$H and $^3$He, where the nuclear effects are larger than for deuterium but expected to largely cancel in the cross-section ratios. We extracted values of the neutron magnetic form factor for low-to-modest momentum transfer, $0.6<Q^2<2.9$ GeV$^2$, where existing measurements give inconsistent results. The precision and $Q^2$ range of this data allow for a better understanding of the current world's data, and suggest a path toward further improvement of our overall understanding of the neutron's magnetic form factor

Revealing the short-range structure of the "mirror nuclei" 3^3H and 3^3He

When protons and neutrons (nucleons) are bound into atomic nuclei, they are close enough together to feel significant attraction, or repulsion, from the strong, short-distance part of the nucleon-nucleon interaction. These strong interactions lead to hard collisions between nucleons, generating pairs of highly-energetic nucleons referred to as short-range correlations (SRCs). SRCs are an important but relatively poorly understood part of nuclear structure and mapping out the strength and isospin structure (neutron-proton vs proton-proton pairs) of these virtual excitations is thus critical input for modeling a range of nuclear, particle, and astrophysics measurements. Hitherto measurements used two-nucleon knockout or ``triple-coincidence'' reactions to measure the relative contribution of np- and pp-SRCs by knocking out a proton from the SRC and detecting its partner nucleon (proton or neutron). These measurementsshow that SRCs are almost exclusively np pairs, but had limited statistics and required large model-dependent final-state interaction (FSI) corrections. We report on the first measurement using inclusive scattering from the mirror nuclei $^3$H and $^3$He to extract the np/pp ratio of SRCs in the A=3 system. We obtain a measure of the np/pp SRC ratio that is an order of magnitude more precise than previous experiments, and find a dramatic deviation from the near-total np dominance observed in heavy nuclei. This result implies an unexpected structure in the high-momentum wavefunction for $^3$He and $^3$H. Understanding these results will improve our understanding of the short-range part of the N-N interaction

Inclusive studies of two- and three-nucleon short-range correlations in 3^3H and 3^3He

Inclusive electron scattering at carefully chosen kinematics can isolate scattering from short-range correlations (SRCs), produced through hard, short-distance interactions of nucleons in the nucleus. Because the two-nucleon (2N) SRCs arise from the same N-N interaction in all nuclei, the cross section in the SRC-dominated regime is identical up to an overall scaling factor, and the A/2H cross section ratio is constant in this region. This scaling behavior has been used to identify SRC dominance and to map out the contribution of SRCs for a wide range of nuclei. We examine this scaling behavior at lower momentum transfers using new data on $^2$H, $^3$H, and $^3$He which show that the scaling region is larger than in heavy nuclei. Based on the improved scaling, especially for $^3$H/$^3$He, we examine the ratios at kinematics where three-nucleon SRCs may play an important role. The data for the largest initial nucleon momenta are consistent with isolation of scattering from 3N-SRCs, and suggest that the very-highest momentum nucleons in $^3$He have a nearly isospin-independent momentum configuration, or a small enhancement of the proton distribution