ADP correspondence system: Unsolicited proposal evaluation tracking application

A complete description of a correspondence control system, designed to be used by non-ADP clerical personnel is provided. In addition to operating instructions, sufficient design and conceptual information is provided to allow use or adaption of the system in related applications. The complete COBOL program and documentation are available

Changing communication on researchgate through interface updates

Informal scholarly communication across the Web is a growing component of the scholarly communication infrastructure. This study describes the effects of three different interfaces on these informal channels. Interface design has a widely studied effect on user behavior, and new users often encounter barriers during accessing social media tools. Using a mixed methods approach, we collected and grouped 413 posts across three distinct interfaces of ResearchGate's communication platform. Our results show that scholars were more polite in the initial group discussion interface but that user interface design did not change the core communication patterns of sharing information and opinions among scholars. The site also transitioned from one-to-many discussions to one-to-one posts, but new users were generally welcomed to the scholarly communications

Sites of Biosynthesis of Outer and Inner Membrane Proteins of Neurospora crassa Mitochondria

Outer and inner membranes of Neurospora crassa mitochondria were separated by the combined swelling, shrinking, sonication procedure. Membranes were characterized by electron microscopy and by marker enzyme activities. A red carotenoid pigment was found to be concentrated in the outer membrane. The inner mitochondrial membrane was resolved into about 20 protein bands on polyacrylamide gel electrophoresis, whereas the outer membrane shows essentially one single protein band. Only negligible incorporation of radioactive amino acids occurs into outer membrane when isolated mitochondria are synthesizing polypeptide chains. In agreement with this observation labeling of outer membrane protein is almost entirely blocked, when whole Neurospora cells are incubated with radioactive amino acids in the presence of cycloheximide, an inhibitor of cytoplasmic protein synthesis. Finally, the essential electrophoretic protein band from outer membrane does not become labeled when mitochondria are incubated with radioactive amino acids either in vitro or in vivo in the presence of cycloheximide. It is concluded that the vast majority, if not all, of the outer membrane protein is synthesized by the cytoplasmic system and that polypeptide chains formed by the mitochondrial ribosomes are integrated into the inner mitochondrial membrane

John Maynard Keynes of Bloomsbury: Four short talks

Four talks on Keynes in relation to the Bloomsbury Group: I. Maynard Keynes of Bloomsbury (Craufurd Goodwin); II. Keynes as Policy Advisor (E. Roy Weintraub); III. Keynes and Economics (Kevin D. Hoover); IV. Keynes and Hayek (Bruce Caldwell). The talks were delivered as part of roundtable discussion on John Maynard Keynes of Bloomsbury, the inaugural event of the Center for the History of Political Economy at Duke University, and were held in conjunction with Vision and Design: A Year of Bloomsbury, a campus-wide interdisciplinary program surrounding an exhibition of Bloomsbury art at Duke University's Nasher Museum of Art

Answer quality characteristics and prediction on an academic QandA site: A case study on researchgate

Despite various studies on examining and predicting answer quality on generic social QandA sites such as Yahoo! Answers, little is known about why answers on academic QandA sites are voted on by scholars who follow the discussion threads to be high quality answers. Using 1021 answers obtained from the QandA part of an academic social network site ResearchGate (RG), we firstly explored whether various web-captured features and human-coded features can be the critical factors that influence the peer-judged answer quality. Then using the identified critical features, we constructed three classification models to predict the peer-judged rating. Our results identify four main findings. Firstly, responders' authority, shorter response time and greater answer length are the critical features that positively associate with the peer-judged answer quality. Secondly, answers containing social elements are very likely to harm the peer-judged answer quality. Thirdly, an optimized SVM algorithm has an overwhelming advantage over other models in terms of accuracy. Finally, the prediction based on web-captured features had better performance when comparing to prediction on human-coded features. We hope that these interesting insights on ResearchGate's answer quality can help the further design of academic QandA sites

Stable isotope values in modern bryozoan carbonate from New Zealand and implications for paleoenvironmental interpretation

Bryozoan carbonate contains useful geochemical evidence of temperate shelf paleoenvironments. Stable isotope values were determined for 103 modern marine bryozoan skeletons representing 30 species from New Zealand. δ18O values range from -1.4 to 2.8 VPDB, while δ13C range from -4.5 to 2.8 VPDB (values uncorrected for mineralogical variation). These values are distinct from those of both tropical marine skeletons and New Zealand Tertiary fossils. Most bryozoans secrete carbonate in or near isotopic equilibrium with sea water, except for Celleporina and Steginoporella. The complex and variable mineralogies of the bryozoans reported here make correction for mineralogical effects problematic. Nevertheless, mainly aragonitic forms display higher isotope values, as anticipated. Both temperature and salinity constrain δ18O and δ13C values, and vary with latitude and water depth. Ten samples from a single branch of Cinctipora elegans from the Otago shelf cover a narrow range, although the striking difference in carbon isotope values between the endozone and exozone probably reflects different mineralisation histories. Our stable isotope results from three different laboratories on a single population from a single location are encouragingly consistent. Monomineralic bryozoans, when carefully chosen to avoid species suspected of vital fractionation, have considerable potential as geochemical paleoenvironmental indicators, particularly in temperate marine environments where bryozoans are dominant sediment producers

Nonlinear software sensor for monitoring genetic regulation processes with noise and modeling errors

Nonlinear control techniques by means of a software sensor that are commonly used in chemical engineering could be also applied to genetic regulation processes. We provide here a realistic formulation of this procedure by introducing an additive white Gaussian noise, which is usually found in experimental data. Besides, we include model errors, meaning that we assume we do not know the nonlinear regulation function of the process. In order to illustrate this procedure, we employ the Goodwin dynamics of the concentrations [B.C. Goodwin, Temporal Oscillations in Cells, (Academic Press, New York, 1963)] in the simple form recently applied to single gene systems and some operon cases [H. De Jong, J. Comp. Biol. 9, 67 (2002)], which involves the dynamics of the mRNA, given protein, and metabolite concentrations. Further, we present results for a three gene case in co-regulated sets of transcription units as they occur in prokaryotes. However, instead of considering their full dynamics, we use only the data of the metabolites and a designed software sensor. We also show, more generally, that it is possible to rebuild the complete set of nonmeasured concentrations despite the uncertainties in the regulation function or, even more, in the case of not knowing the mRNA dynamics. In addition, the rebuilding of concentrations is not affected by the perturbation due to the additive white Gaussian noise and also we managed to filter the noisy output of the biological systemComment: 21 pages, 7 figures; also selected in vjbio of August 2005; this version corrects a misorder in the last three references of the published versio

Neutrino Interactions in Hot and Dense Matter

We study the charged and neutral current weak interaction rates relevant for the determination of neutrino opacities in dense matter found in supernovae and neutron stars. We establish an efficient formalism for calculating differential cross sections and mean free paths for interacting, asymmetric nuclear matter at arbitrary degeneracy. The formalism is valid for both charged and neutral current reactions. Strong interaction corrections are incorporated through the in-medium single particle energies at the relevant density and temperature. The effects of strong interactions on the weak interaction rates are investigated using both potential and effective field-theoretical models of matter. We investigate the relative importance of charged and neutral currents for different astrophysical situations, and also examine the influence of strangeness-bearing hyperons. Our findings show that the mean free paths are significantly altered by the effects of strong interactions and the multi-component nature of dense matter. The opacities are then discussed in the context of the evolution of the core of a protoneutron star.Comment: 41 pages, 25 figure