32 research outputs found
Microscopic Approach to Shear Viscosities in Superfluid Gases: From BCS to BEC
We compute the shear viscosity, , at general temperatures , in a
BCS-BEC crossover scheme which is demonstrably consistent with conservation
laws. The study of is important because it constrains microscopic
theories by revealing the excitation spectra. The onset of a normal state
pairing gap and the contribution from pair degrees of freedom imply that
at low becomes small, rather than exhibiting the upturn predicted by most
others. Using the local density approximation, we find quite reasonable
agreement with just-published experiments.Comment: 4 pages, 2 figure
Searching for Perfect Fluids: Quantum Viscosity in a Universal Fermi Gas
We measure the shear viscosity in a two-component Fermi gas of atoms, tuned
to a broad s-wave collisional (Feshbach) resonance. At resonance, the atoms
strongly interact and exhibit universal behavior, where the equilibrium
thermodynamic properties and the transport coefficients are universal functions
of the density and temperature . We present a new calibration of the
temperature as a function of global energy, which is directly measured from the
cloud profiles. Using the calibration, the trap-averaged shear viscosity in
units of is determined as a function of the reduced temperature at
the trap center, from nearly the ground state to the unitary two-body regime.
Low temperature data is obtained from the damping rate of the radial breathing
mode, while high temperature data is obtained from hydrodynamic expansion
measurements. We also show that the best fit to the high temperature expansion
data is obtained for a vanishing bulk viscosity. The measured trap-averaged
entropy per particle and shear viscosity are used to estimate the ratio of the
shear viscosity to the entropy density, which is compared that conjectured for
a perfect fluid.Comment: 20 pages, 10 figure
Observation of a pairing pseudogap in a two-dimensional Fermi gas
Pairing of fermions is ubiquitous in nature and it is responsible for a large
variety of fascinating phenomena like superconductivity, superfluidity of
He, the anomalous rotation of neutron stars, and the BEC-BCS crossover in
strongly interacting Fermi gases. When confined to two dimensions, interacting
many-body systems bear even more subtle effects, many of which lack
understanding at a fundamental level. Most striking is the, yet unexplained,
effect of high-temperature superconductivity in cuprates, which is intimately
related to the two-dimensional geometry of the crystal structure. In
particular, the questions how many-body pairing is established at high
temperature and whether it precedes superconductivity are crucial to be
answered. Here, we report on the observation of pairing in a harmonically
trapped two-dimensional atomic Fermi gas in the regime of strong coupling. We
perform momentum-resolved photoemission spectroscopy, analogous to ARPES in the
solid state, to measure the spectral function of the gas and we detect a
many-body pairing gap above the superfluid transition temperature. Our
observations mark a significant step in the emulation of layered
two-dimensional strongly correlated superconductors using ultracold atomic
gases
Unconventional particle-hole mixing in the systems with strong superconducting fluctuations
Development of the STM and ARPES spectroscopies enabled to reach the
resolution level sufficient for detecting the particle-hole entanglement in
superconducting materials. On a quantitative level one can characterize such
entanglement in terms of the, so called, Bogoliubov angle which determines to
what extent the particles and holes constitute the spatially or momentum
resolved excitation spectra. In classical superconductors, where the phase
transition is related to formation of the Cooper pairs almost simultaneously
accompanied by onset of their long-range phase coherence, the Bogoliubov angle
is slanted all the way up to the critical temperature Tc. In the high
temperature superconductors and in superfluid ultracold fermion atoms near the
Feshbach resonance the situation is different because of the preformed pairs
which exist above Tc albeit loosing coherence due to the strong quantum
fluctuations. We discuss a generic temperature dependence of the Bogoliubov
angle in such pseudogap state indicating a novel, non-BCS behavior. For
quantitative analysis we use a two-component model describing the pairs
coexisting with single fermions and study their mutual feedback effects by the
selfconsistent procedure originating from the renormalization group approach.Comment: 4 pages, 4 figure
Appearance of fluctuating stripes at the onset of the pseudogap in the high-Tc Superconductor Bi2Sr2CaCu2O8+x
Doped Mott insulators have been shown to have a strong propensity to form
patterns of holes and spins often referred to as stripes. In copper-oxides,
doping also gives rise to the pseudogap state, which transforms into a high
temperature superconductor with sufficient doping or by reducing the
temperature. A long standing question has been the interplay between pseudogap,
which is generic to all hole-doped cuprates, and stripes, whose static form
occurs in only one family of cuprates over a narrow range of the phase diagram.
Here we examine the spatial reorganization of electronic states with the onset
of the pseudogap state at T* in the high-temperature superconductor
Bi2Sr2CaCu2O8+x using spectroscopic mapping with the scanning tunneling
microscope (STM). We find that the onset of the pseudogap phase coincides with
the appearance of electronic patterns that have the predicted characteristics
of fluctuating stripes. As expected, the stripe patterns are strongest when the
hole concentration in the CuO2 planes is close to 1/8 (per Cu). While
demonstrating that the fluctuating stripes emerge with the onset of the
pseudogap state and occur over a large part of the cuprate phase diagram, our
experiments indicate that they are a consequence of pseudogap behavior rather
than its cause.Comment: preprint version, 25 pages including supplementary informatio
THE EFFICACY OF RENALTONICANDBLOOD-BOOSTINGFORMULAWITH BONE PEPTIDE INJECTION IN THE TREATMENT OF OSTEOPOROSIS
Recombinant Erythroid Kruppel-Like Factor Fused to GATA1 up-Regulates δ-Globin Expression In Erythroid Cells.
Abstract
Abstract 3752
The β-hemoglobinopathies sickle cell disease and β-thalassemia are among the most common human genetic disorders worldwide. Hemoglobin A2 (HbA2, α2δ2) and fetal hemoglobin (HbF, a2γ2) both inhibit the polymerization of hemoglobin S that results in erythrocyte sickling. Expression of erythroid Kruppel-like factor (EKLF) and GATA1 is critical for transitioning hemoglobin from HbF to hemoglobin A (HbA, α2β2) and HbA2. The lower levels of δ-globin expression compared with β-globin expression seen in adulthood are likely due to the absence of an EKLF-binding motif in the δ-globin proximal promoter. In an effort to upregulate δ-globin to increase HbA2 expression, we created a series of EKLF-GATAl fusion constructs composed of the transactivation domain of EKLF and the DNA-binding domain of GATAl and then tested their effects on hemoglobin expression. EKLF-GATAl fusion proteins activated δ-, γ-, and β-globin promoters in K562 cells, and significantly upregulated δ- and γ-globin RNA transcripts and proteins expression in K562 and CD34+ cells. The binding of EKLF-GATA1 fusion proteins at the GATA1 consensus site in the δ-globin promoter was confirmed by chromatin immunoprecipitation assay. Our studies demonstrate that EKLF-GATA1 fusion proteins can enhance δ-globin expression through interaction with the δ-globin promoter, and may represent a potentially new genetic therapeutic approach to β-hemoglobinopathies.
Disclosures:
No relevant conflicts of interest to declare.
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