10 research outputs found
Protein quantification in ecological studies: A literature review and empirical comparisons of standard methodologies
No full textHomocysteine fibrillar assemblies display cross-talk with Alzheimer’s disease β-amyloid polypeptide
Full text linkSignificance
The accumulation of homocysteine, a key metabolite, is considered a risk factor for Alzheimer’s disease. This work demonstrates the ability of homocysteine to form ordered fibrillar structures. The toxicity of these structures is demonstrated in a yeast model that accumulates homocysteine. We further show the association of this observation with Alzheimer's disease pathology, including induced aggregation of a pathological protein and the presence of homocysteine structures in the brain of model mice. We suggest the targeting of homocysteine structure formation as a direction for Alzheimer's disease therapeutics.</jats:p
Oxidized low-density lipoprotein stimulates dendritic cells maturation via LOX-1-mediated MAPK/NF-κB pathway
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A representação do consumo de bebidas alcoólicas para adolescentes atendidos em uma Unidade de Saúde da Família
No full textFibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
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