Magnetic fields

Effects of high and low gradient magnetic fields on human performance for space flight application

Ultrasound Guided Placement of Single-Lumen Peripheral Intravenous Catheters in the Internal Jugular Vein

Introduction: The peripheral internal jugular (IJ), also called the “easy IJ,” is an alternative to peripheral venous access reserved for patients with difficult intravenous (IV) access. The procedure involves placing a single-lumen catheter in the IJ vein under ultrasound (US) guidance. As this technique is relatively new, the details regarding the ease of the procedure, how exactly it should be performed, and the safety of the procedure are uncertain. Our primary objective was to determine the success rate for peripheral IJ placement. Secondarily, we evaluated the time needed to complete the procedure and assessed for complications. Methods: This was a prospective, single-center study of US-guided peripheral IJ placement using a 2.5-inch, 18-gauge catheter on a convenience sample of patients with at least two unsuccessful attempts at peripheral IV placement by nursing staff. Peripheral IJ lines were placed by emergency medicine (EM) attending physicians and EM residents who had completed at least five IJ central lines. All physicians who placed lines for the study watched a 15-minute lecture about peripheral IJ technique. A research assistant monitored each line to assess for complications until the patient was discharged. Results: We successfully placed a peripheral IJ in 34 of 35 enrolled patients (97.1%). The median number of attempts required for successful cannulation was one (interquartile range (IQR): 1 to 2). The median time to successful line placement was 3 minutes and 6 seconds (IQR: 59 seconds to 4 minutes and 14 seconds). Two lines failed after placement, and one of the 34 successfully placed peripheral IJ lines (2.9%) had a complication – a local hematoma. There were, however, no arterial punctures or pneumothoraces. Although only eight of 34 lines were placed using sterile attire, there were no line infections. Conclusion: Our research adds to the growing body of evidence supporting US-guided peripheral internal jugular access as a safe and convenient procedure alternative for patients who have difficult IV access

Economics of Increased Beef Grader Accuracy

Carcass data from more than 38,000 cattle was used to compare the called and measured yield grade in two different periods: before and after the slaughter plant incorporated another grader in the line to improve grading accuracy. The study shows that the graders accuracy significantly increased. The higher accuracy affected all yield grades, but most notably resulted in more called yield grade 4 and 5 carcasses. This analysis will develop insight of what will be the effect of instrument grading that will be more accurate than previously called grades.The results are expressed as the conditional distribution of the called yield grade for a given value of the measured yield grade. The pricing grid currently used by the industry was used to analyze the effect of the graders errors on the expected values of the premiums on both periods and by yield grade. The results show that the company has an incentive to improve accuracy of grading. Simulating the results of measured vs. called yield grade over prices at the time and a standard industry grid showed that the plant can benefit by $1.32 per head by increasing grading accuracy.cattle, carcass grading, accuracy, economics of grading,

Geophysical exploration for groundwater resources over the volcanic rocks of the Troodos Ophiolite Complex, Cyprus

The volcanic rocks of the Troodos Ophiolite Complex in Cyprus represent a poor groundwater source. However in regions where groundwater systems are developed along fracture zones, water boreholes are capable of providing water for the local community, particularly for agriculture. In order to increase the success rate of water boreholes several geophysical methods were trialed to investigate their ability to locate and charaterise fracture zones. Azimuthal apparent resistivity (AZR), very low frequency electromagnetics (VLF) and audio-magnetotellurics (AMT) were applied at a number of test sites on the Upper and Lower Pillow Lava series and pillow lavas and dykes of the Basal Group. No distinct fracture zones were identified by the measurements. A conductive zone was identified over pillow lavas by AMT, but may have been due to a porous/more fractured layer or the conductive pillow lavas. The AZR results clearly demonstrate the heterogeneous nature of the Troodos volcanic rocks. Fracturing, where it has been identified, appears to be localised and to be of limited lateral extent. Azimuthal apparent resistivity is unlikely to be successful as a primary geophysical technique in the exploration for groundwater resources over the Troodos volcanic rocks. However it may be useful as a secondary technique, perhaps for tracing the strike of a known fracture zone which gives high water yields. Due to the conductive nature of the pillow lavas the resistivity contrast offered by any near-surface fracture zones will inevitably be small and likely to be below the detection limits of VLF

A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.

Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases. Noted issues with PZA Drug Susceptibility Testing (DST) have driven the search for alternative tests. This study provides a comprehensive assessment of PZA molecular diagnostics in M/XDR TB cases. A set of 296, mostly XDR, clinical M. tuberculosis isolates from four countries were subjected to DST for eight drugs, confirmatory Wayne's assay, and whole-genome sequencing. Three genes implicated in PZA resistance, pncA, rpsA, and panD were investigated. Assuming all non-synonymous mutations cause resistance, we report 90% sensitivity and 65% specificity for a pncA-based molecular test. The addition of rpsA and panD potentially provides 2% increase in sensitivity. Molecular heterogeneity in pncA was associated with resistance and should be evaluated as a diagnostic tool. Mutations near the N-terminus and C-terminus of PZase were associated with East-Asian and Euro-American lineages, respectively. Finally, Euro-American isolates are most likely to have a wild-type PZase and escape molecular detection. Overall, the 8-10% resistance without markers may point to alternative mechanisms of resistance. Confirmatory mutagenesis may improve the disconcertingly low specificity but reduce sensitivity since not all mutations may cause resistance

Hydrogeological classification of superficial clays: apparent resistivity measurements from the Garboldisham, Norfolk pilot study area

Three types of apparent resistivity measurements have been undertaken at the Garboldisham pilot study area in Norfolk in support of the superficial clays programme. Resistivity soundings have established the intrinsic resistivities for the strata encountered. Cover sand (possibly mixed with glacial sand) ofresistivities 100 - 200 ohm.m overlies till ofresistivities 22 - 32 ohm.m which lies directly on chalk of resistivities 65 - 85 ohm.m. At the sounding sites, depth to chalk is in the range 11 - 15 m. Azimuthal apparent resistivity measurements were made in an attempt to identify fracture sets within the till and to establish the degree of fracturing between measurement sites. These fracture sets will have an important influence on the hydrogeological regime. At only two of the five sites investigated was a fracture trend recognised and this had an orientation of 210-225 degrees. There was an indication of a change in the intensity of fracturing between the two sites. The results indicate that there is either a lack of fracturing with a consistent trend within the till or that there is an insufficient resistivity contrast between the conductive till and the fractures. Detailed dipole-dipole apparent resistivity measurements undertaken with the BGS RESCAN system were able to map the thickness ofcover sand over a suspected sand channel. The sand body has a north - south orientation with a variable depth to the till surface. Maximum depths are up to two metres. The effectiveness of the resistivity technique for mapping sand lying on till has been demonstrated in this study

Initiating haemodialysis twice-weekly as part of an incremental programme may protect residual kidney function

© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.Background: Initiating twice-weekly haemodialysis (2×HD) in patients who retain significant residual kidney function (RKF) may have benefits. We aimed to determine differences between patients initiated on twice- and thrice-weekly regimes, with respect to loss of kidney function, survival and other safety parameters. Methods: We conducted a single-centre retrospective study of patients initiating dialysis with a residual urea clearance (KRU) of ≥3 mL/min, over a 20-year period. Patients who had 2×HD for ≥3 months during the 12 months following initiation of 2×HD were identified for comparison with those dialysed thrice-weekly (3×HD). Results: The 2×HD group consisted of 154 patients, and the 3×HD group 411 patients. The 2×HD patients were younger (59 ± 15 versus 62 ± 15 years: P = 0.014) and weighed less (70 ± 16 versus 80 ± 18 kg: P < 0.001). More were females (34% versus 27%: P = 0.004). Fewer had diabetes (25% versus 34%: P = 0.04) and peripheral vascular disease (PVD) (13% versus 23%: P = 0.008). Baseline KRU was similar in both groups (5.3 ± 2.4 for 2 × HD versus 5.1 ± 2.8 mL/min for 3 × HD: P = 0.507). In a mixed effects model correcting for between-group differences in comorbidities and demographics, 3×HD was associated with increased rate of loss of KRU and separation of KRU. In separate mixed effects models, group (2×HD versus 3×HD) was not associated with differences in serum potassium or phosphate, and the groups did not differ with respect to total standard Kt/V. Survival, adjusted for age, gender, weight, baseline KRU and comorbidity (prevalence of diabetes, cardiac disease, PVD and malignancy) was greater in the 2×HD group (hazard ratio 0.755: P = 0.044). In sub-analyses, the survival benefit was confined to women, and those of less than median bodyweight. Conclusion: 2×HD initiation as part of an incremental programme with regular monthly monitoring of KRU was safe and associated with a reduced rate of loss of RKF early after dialysis initiation and improved survival. Randomized controlled trials of this approach are indicated.Peer reviewedFinal Accepted Versio

An evaluation of combined geophysical and geotechnical methods to characterize beach thickness

Beaches provide sediment stores and have an important role in the development of the coastline in response to climate change. Quantification of beach thickness and volume is required to assess coastal sediment transport budgets. Therefore, portable, rapid, non-invasive techniques are required to evaluate thickness where environmental sensitivities exclude invasive methods. Site methods and data are described for a toolbox of electrical, electromagnetic, seismic and mechanical based techniques that were evaluated at a coastal site at Easington, Yorkshire. Geophysical and geotechnical properties are shown to be dependent upon moisture content, porosity and lithology of the beach and the morphology of the beach–platform interface. Thickness interpretation, using an inexpensive geographic information system to integrate data, allowed these controls and relationships to be understood. Guidelines for efficient site practices, based upon this case history including procedures and techniques, are presented using a systematic approach. Field results indicated that a mixed sand and gravel beach is highly variable and cannot be represented in models as a homogeneous layer of variable thickness overlying a bedrock half-space

Hemoglobin genotype has minimal influence on the physiological response of juvenile atlantic cod (Gadus morhua) to environmental challenges

Hemoglobin (Hb) polymorphism in cod is associated with temperature‐related differences in biogeographical distribution, and several authors have suggested that functional characteristics of the various hemoglobin isoforms (HbIs) directly influence phenotypic traits such as growth rate. However, no study has directly examined whether Hb genotype translates into physiological differences at the whole animal level. Thus, we generated a family of juvenile Atlantic cod consisting of all three main Hb genotypes (HbI‐1/1, HbI‐2/2, and HbI‐1/2) by crossing a single pair of heterozygous parents, and we compared their metabolic and cortisol responses to an acute thermal challenge (10&deg;C to their critical thermal maximum [CTM] or 22&deg;C, respectively) and tolerance of graded hypoxia. There were no differences in routine metabolism (at 10&deg;C), maximum metabolic rate, metabolic scope, CTM (overall mean 22.9&deg; &plusmn; 0.2&deg;C), or resting and poststress plasma cortisol levels among Hb genotypes. Further, although the HbI‐1/1 fish grew more (by 15%&ndash;30% during the first 9 mo) when reared at 10&deg; &plusmn; 1&deg;C and had a slightly enhanced hypoxia tolerance at 10&deg;C (e.g., the critical O2 levels for HbI‐1/1, HbI‐2/2, and HbI‐1/2 cod were 35.56% &plusmn; 1.24%, and 40.20% &plusmn; 1.99% air saturation, respectively), these results are contradictory to expectations based on HbI functional properties. Thus, our findings (1) do not support previous assumptions that growth rate differences among cod Hb genotypes result from a more efficient use of the oxygen supply&mdash;that is, reduced standard metabolic rates and/or increased metabolic capacity&mdash;and (2) suggest that in juvenile cod, there is no selective advantage to having a particular Hb genotype with regards to the capacity to withstand ecologically relevant environmental challenges.<br /