Transferrin changes in haemodialysed patients

Transferrin (Tf) is a glycoprotein responsible for iron transport in the human body. Physiologically in reaction with Concanavalin A, Tf occurs in four distinct variants Tf1, Tf2, Tf3 (apo-Tf) and Tf4. It was reported recently that Tf is changing, particularly during acute phase response, taking place among others in end-stage renal disease. In this study, we wanted to find the answer to three main questions: firstly, how Tf is changing in patients treated with maintenance haemodialysis (mHD), secondly, whether there are any Tf changes in the course of mHD treatment, and thirdly, what factors can affect Tf microheterogeneity in these patients. Studies were performed on 80 haemodialysed patients and 21 healthy volunteers. The Tf concentration was determined by the rocket immunoelectrophoresis, and its microheterogeneity was assessed by the ConA crossed immunoaffinity electrophoresis. During the annual observation of the distribution of the Tf variants, we have found both changes of the percentage contents of all Tf variants in the whole Tf concentration and a significant decrease in Tf2, Tf3 and Tf4 serum concentrations. Moreover, we found that decrease in the renal function, duration of mHD, and inflammation may contribute to these above-mentioned changes, which are probably the factors that should be taken into account when explaining the mechanisms of persistence of anaemia in haemodialysed patients

Trust predicts COVID-19 prescribed and discretionary behavioral intentions in 23 countries

The worldwide spread of a new coronavirus (SARS-CoV-2) since December 2019 has posed a severe threat to individuals well-being. While the world at large is waiting that the released vaccines immunize most citizens, public health experts suggest that, in the meantime, it is only through behavior change that the spread of COVID-19 can be controlled. Importantly, the required behaviors are aimed not only at safeguarding one s own health. Instead, individuals are asked to adapt their behaviors to protect the community at large. This raises the question of which social concerns and moral principles make people willing to do so. We considered in 23 countries (N = 6948) individuals willingness to engage in prescribed and discretionary behaviors, as well as country-level and individual-level factors that might drive such behavioral intentions. Results from multilevel multiple regressions, with country as the nesting variable, showed that publicized number of infections were not significantly related to individual intentions to comply with the prescribed measures and intentions to engage in discretionary prosocial behaviors. Instead, psychological differences in terms of trust in government, citizens, and in particular toward science predicted individuals behavioral intentions across countries. The more people endorsed moral principles of fairness and care (vs. loyalty and authority), the more they were inclined to report trust in science, which, in turn, statistically predicted prescribed and discretionary behavioral intentions. Results have implications for the type of intervention and public communication strategies that should be most effective to induce the behavioral changes that are needed to control the COVID-19 outbreak

Naturally occurring variation in tadpole morphology and performance linked to predator regime

Divergent natural selection drives a considerable amount of the phenotypic and genetic variation observed in natural populations. For example, variation in the predator community can generate conflicting selection on behavioral, life-history, morphological, and performance traits. Differences in predator regime can subsequently increase phenotypic and genetic variations in the population and result in the evolution of reproductive barriers (ecological speciation) or phenotypic plasticity. We evaluated morphology and swimming performance in field collected Bronze Frog larvae (Lithobates clamitans) in ponds dominated by predatory fish and those dominated by invertebrate predators. Based on previous experimental findings, we hypothesized that tadpoles from fish-dominated ponds would have small bodies, long tails, and large tail muscles and that these features would facilitate fast-start speed. We also expected to see increased tail fin depth (i.e., the tail-lure morphology) in tadpoles from invertebrate-dominated ponds. Our results support our expectations with respect to morphology in affecting swimming performance of tadpoles in fish-dominated ponds. Furthermore, it is likely that divergent natural selection is playing a role in the diversification on morphology and locomotor performance in this system

Effects of Psychological Distance on Mental Abstraction: A Registered Report of Four Tests of Construal Level Theory

Construal level theory (CLT) proposes that psychological distance influences the level of abstraction at which something is mentally construed: things perceived as less probable (likelihood) or further away from the here (spatial distance), now (temporal distance), or self (social distance) are thought about more abstractly. This international multi-lab study tests four basic hypotheses derived from core assumptions of CLT and explores potential moderators and boundary conditions of the effects. Participants (N = 11,775) from 27 countries and regions were randomly assigned to one of four experimental protocols focused on different types of psychological distance (temporal, spatial, social, or likelihood), and each experiment manipulated psychological distance (close vs. distant). The protocols for temporal distance (N = 2,941) and spatial distance (N = 2,973) were direct replications of Liberman and Trope (1998, Study 1) and Fujita et al. (2006, Study 1), respectively. The remaining two protocols were paradigmatic replications, applying to social distance (N = 2,926) and likelihood (N = 2,936). The effects of psychological distance on construal level for the four present studies were (original effects within parentheses; positive effects are consistent with hypotheses): dtemporal = 0.08, 95% CI [0.003, 0.16] (cf. d = 0.92); dspatial = 0.04, 95% CI [-0.03, 0.11] (cf. d = 0.55); dsocial = -0.27, 95% CI [-0.34, -0.19]; and dlikelihood = 0.03, 95% CI [-0.05, 0.11]. Pretests indicated that valence and abstraction were confounded in response options on the outcome measure. Controlling for this confound eliminated the hypothesis-inconsistent effect of social distance, d = 0.006, 95% CI [-0.05, 0.07]. These findings provide limited evidence for the predictions of the theory and present a critical challenge for CLT