Effects of microgravity on rat muscle

It is well known that humans exposed to long term spaceflight experience undesirable progressive muscle weakness and increased fatigability. This problem has prompted the implementation of inflight exercise programs because most investigators believe that the major cause of diminished muscle performance is a combination of disuse and decreased workload. Inflight exercise has improved muscle health, but deficits have persisted, indicating that either the regimens utilized were suboptimal or there existed additional debilitating factors which were not remedied by exercise. Clarification of this question requires an improved understanding of the cellular and molecular basis of spaceflight-induced muscle deterioration. To this end, multiple investigations have been performed on the muscles from rats orbited 5 to 22 days in Cosmos biosatellites and Spacelab-3 (2,4,5,8,10 to 14,16,18,19,21 to 23,25,27,28). The eight Cosmos 1887 investigations examined the structural and biochemical changes in skeletal and cardiac muscles of rats exposed to microgravity for 12.5 days and returned to terrestrial gravity 2.3 days before tissues were collected. Even though interpretation of these results was complicated by the combination of inflight and postflight induced alterations, the consensus is that there is marked heterogeneity in both degree and type of responses from the whole muscle level down to the molecular level. Collectively, the muscle investigations of Cosmos 1887 clearly illustrate the wide diversity of muscle tissue responses to spaceflight. Judging from the summary report of this mission, heterogeneity of responses is not unique to muscle tissue. Elucidating the mechanism underlying this heterogeneity holds the key to explaining adaptation of the organism to prolonged spaceflight

The role of proteases in pathologies of the synovial joint

Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation. Pathologies of the synovial joint are an important cause of patient morbidity and can affect each of the constituent tissues. A common feature of these pathologies is degenerative changes in the structure of the tissue which is mediated, at least in part, by proteolytic activity. Most tissues of the synovial joint are composed primarily of extracellular matrix and key pathological roles in the degeneration of this matrix are performed by metalloproteinases such as matrix metallproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS). However, other proteases such as cathepsin K are likely to play an important role, especially in bone turnover. In addition to the cleavage of structural proteins, proteolytic activities are employed to regulate the activity of other proteases, growth factors, cytokines and other inflammatory mediators. Proteases combine to form complex regulatory networks, the correct functioning of which is required for tissue homeostasis and the imbalance of which may be a feature of pathology. A precise understanding of the proteases involved in these networks is required for a true understanding of the associated pathology

A note on leapfrogging vortex rings

In this paper we provide examples, by numerical simulation using the Navier-Stokes equations for axisymmetric laminar flow, of the 'leapfrogging' motion of two, initially identical, vortex rings which share a common axis of symmetry. We show that the number of clear passes that each ring makes through the other increases with Reynolds number, and that as long as the configuration remains stable the two rings ultimately merge to form a single vortex ring

Power law burst and inter-burst interval distributions in the solar wind: turbulence or dissipative SOC ?

We calculate for the first time the probability density functions (PDFs) P of burst energy e, duration T and inter-burst interval tau for a known turbulent system in nature. Bursts in the earth-sun component of the Poynting flux at 1 AU in the solar wind were measured using the MFI and SWE experiments on the NASA WIND spacecraft. We find P(e) and P(T) to be power laws, consistent with self-organised criticality (SOC). We find also a power law form for P(tau) that distinguishes this turbulent cascade from the exponential P(tau) of ideal SOC, but not from some other SOC-like sandpile models. We discuss the implications for the relation between SOC and turbulence.Comment: 3 pages, 1 figure. Submitted to PRL on 25th February 2000. Revised version re-submitted on 9th May 2000. Second revised version submitted Phys. Rev. E on 26th June, 200

Development of a low-cost, electricity-generating Rankine cycle, alcohol-fuelled cooking stove for rural communities

This article describes a novel design and construction of a helical tube flash boiler that uses a 2kW nominal methylated spirit burner to heat an approximately 2.5m long coil of copper pipe fed by a nominal 8 bar electrically operated solenoid water pump. The final embodiment is for superheated steam to be converted to electricity and the waste exit heat from the generator used either for cooking or for ethanol pro duction for low-income families in developing countries. The performance of the flash boiler has been evaluated experimentally based on the well-known “Direct-Method”; by carefully measuring both the flow of the fuel and the steam. It found that the pressure inside the pipe can reach up to 7.4 bar and the temperature of the steam released by the flashing process can reach 255°C utilising a low-cost water pump. The research results prese nted in this paper demonstrate that flash boiler stove has a great potential for generating high-temperature steam for developing a low-cost cooking stove

Simulator study of the effect of visual-motion time delays on pilot tracking performance with an audio side task

The effect of time delay was determined in the visual and motion cues in a flight simulator on pilot performance in tracking a target aircraft that was oscillating sinusoidally in altitude only. An audio side task was used to assure the subject was fully occupied at all times. The results indicate that, within the test grid employed, about the same acceptable time delay (250 msec) was obtained for a single aircraft (fighter type) by each of two subjects for both fixed-base and motion-base conditions. Acceptable time delay is defined as the largest amount of delay that can be inserted simultaneously into the visual and motion cues before performance degradation occurs. A statistical analysis of the data was made to establish this value of time delay. Audio side task provided quantitative data that documented the subject's work level

Comparison of analytical predictions of longitudinal short period pilot-induced oscillations with results from a simulation study of the space shuttle orbiter

An analytical analysis of conditions producing pilot induced oscillations (PIO's) was made for the space shuttle orbiter in a landing approach configuration for the task of milling the elevation angle of the line of sight to a target vehicle. The analysis yielded a value of PIO frequency and a value for the amount of total system time delay (pilot + control system) that can be tolerated before instability results. Calculations were performed showing the effect of varying the range to the target and of varying the handling qualities of the orbiter vehicle. Analytical predictions were compared with simulation results obtained using a visual motion simulator

Factors Influencing Marketing Margins in Cattle and Beef Markets

Livestock Production/Industries,