Myocardial interleukin-6 in the setting of left ventricular mechanical assistance: relation with outcome and C-reactive protein

Background: In left ventricular assist device (LVAD) recipients, plasma levels of interleukin (IL)-6 are associated with Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profiles, reflecting postoperative risk. However, it is not clear how the cardiac. Conclusions: Cardiac IL-6 levels do not contribute to improve risk profile of LVAD recipients in relation to clinical inpatient post-implantation. Instead, plasma IL-6 and serum CRP concentrations are more effective in predicting the severity of the clinical course in the early phase of LVAD therapy. level of IL-6, detectable on the tissue samples at the time of implantation, can contribute to predict the post-operative outcome

Significance testing of rank cross-correlations between autocorrelated time series with short-range dependence

Statistical dependency measures such as Kendall’s Tau or Spearman’s Rho are frequently used to analyse the coherence between time series in environmental data analyses. Autocorrelation of the data can, however, result in spurious cross correlations if not accounted for. Here, we present the asymptotic distribution of the estimators of Spearman’s Rho and Kendall’s Tau, which can be used for statistical hypothesis testing of cross-correlations between autocorrelated observations. The results are derived using U-statistics under the assumption of absolutely regular (or β-mixing) processes. These comprise many short-range dependent processes, such as ARMA-, GARCH- and some copula-based models relevant in the environmental sciences. We show that while the assumption of absolute regularity is required, the specific type of model does not have to be specified for the hypothesis test. Simulations show the improved performance of the modified hypothesis test for some common stochastic models and small to moderate sample sizes under autocorrelation. The methodology is applied to observed climatological time series of flood discharges and temperatures in Europe. While the standard test results in spurious correlations between floods and temperatures, this is not the case for the proposed test, which is more consistent with the literature on flood regime changes in Europe

Flood trends in Europe: Are changes in small and big floods different?

Recent studies have revealed evidence of trends in the median or mean flood discharge in Europe over the last 5 decades, with clear and coherent regional patterns. The aim of this study is to assess whether trends in flood discharges also occurred for larger return periods, accounting for the effect of catchment scale. We analyse 2370 flood discharge records, selected from a newly available pan-European flood database, with record length of at least 40 years over the period 1960-2010 and with contributing catchment area ranging from 5 to 100 000 km2. To estimate regional flood trends, we use a non-stationary regional flood frequency approach consisting of a regional Gumbel distribution, whose median and growth factor can vary in time with different strengths for different catchment sizes. A Bayesian Markov chain Monte Carlo (MCMC) approach is used for parameter estimation. We quantify regional trends (and the related sample uncertainties), for floods of selected return periods and for selected catchment areas, across Europe and for three regions where coherent flood trends have been identified in previous studies. Results show that in northwestern Europe the trends in flood magnitude are generally positive. In small catchments (up to 100 km2), the 100-year flood increases more than the median flood, while the opposite is observed in medium and large catchments, where even some negative trends appear, especially in northwestern France. In southern Europe flood trends are generally negative. The 100-year flood decreases less than the median flood, and, in the small catchments, the median flood decreases less compared to the large catchments. In eastern Europe the regional trends are negative and do not depend on the return period, but catchment area plays a substantial role: the larger the catchment, the more negative the trend

Flood trends in Europe: are changes in small and big floods different?

Abstract. Recent studies have revealed evidence of trends in the median or mean flood discharge in Europe over the last 5 decades, with clear and coherent regional patterns. The aim of this study is to assess whether trends in flood discharges also occurred for larger return periods, accounting for the effect of catchment scale. We analyse 2370 flood discharge records, selected from a newly available pan-European flood database, with record length of at least 40 years over the period 1960–2010 and with contributing catchment area ranging from 5 to 100 000 km2. To estimate regional flood trends, we use a non-stationary regional flood frequency approach consisting of a regional Gumbel distribution, whose median and growth factor can vary in time with different strengths for different catchment sizes. A Bayesian Markov chain Monte Carlo (MCMC) approach is used for parameter estimation. We quantify regional trends (and the related sample uncertainties), for floods of selected return periods and for selected catchment areas, across Europe and for three regions where coherent flood trends have been identified in previous studies. Results show that in northwestern Europe the trends in flood magnitude are generally positive. In small catchments (up to 100 km2), the 100-year flood increases more than the median flood, while the opposite is observed in medium and large catchments, where even some negative trends appear, especially in northwestern France. In southern Europe flood trends are generally negative. The 100-year flood decreases less than the median flood, and, in the small catchments, the median flood decreases less compared to the large catchments. In eastern Europe the regional trends are negative and do not depend on the return period, but catchment area plays a substantial role: the larger the catchment, the more negative the trend

Corrigendum to "Spatial moments of catchment rainfall: rainfall spatial organisation, basin morphology, and flood response" published in Hydrol. Earth Syst. Sci., 15, 3767–3783, 2011

No abstract available