Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function.

Background/objectiveYouth with obesity have an altered high-density lipoprotein (HDL) subspecies profile characterized by depletion of large apoE-rich HDL particles and an enrichment of small HDL particles. The goal of this study was to test the hypothesis that this atherogenic HDL profile is reversible and that HDL function would improve with metabolic surgery.MethodsSerum samples from adolescent males with severe obesity mean±s.d. age of 17.4±1.6 years were studied at baseline and 1 year following vertical sleeve gastrectomy (VSG). HDL subspecies and HDL function were evaluated pre and post VSG using paired t-tests. A lean group of adolescents was included as a reference group.ResultsAfter VSG, body mass index decreased by 32% and insulin resistance as estimated by homeostatic model assessment of insulin resistance decreased by 75% (both P<0.01). Large apoE-rich HDL subspecies increased following VSG (P<0.01) and approached that of lean adolescents despite participants with considerable residual obesity. In addition, HDL function improved compared with baseline (cholesterol efflux capacity increased by 12%, HDL lipid peroxidation potential decreased by 30% and HDL anti-oxidative capacity improved by 25%, all P<0.01).ConclusionsMetabolic surgery results in a significant improvement in the quantity of large HDL subspecies and HDL function. Our data suggest metabolic surgery may improve cardiovascular risk in adolescents and young adults

Rabbit Production in Selected Urban Areas of Southern Ghana: Status and Implications for Policy and Research

A survey was conducted to elicit information on rabbit keeping in 26 urban areas of southern Ghana. The average age of the rabbit keepers was 44.3 years, and 95.5% of the keepers had formal education. Most of the producers got into rabbit keeping for money to meet urgent family needs, while household consumption was a major factor influencing the decision for rearing rabbits. Personal savings was the main source of income for the establishment of the rabbit enterprises. The major breeds of rabbits kept were the California White, New Zealand White and crossbreds of varied genetic variations. Backyard, small-scale and medium-scale commercial rabbit holdings were held by 18.2, 51.7 and 30.2% of the keepers respectively. The average rabbit population per farm was 77.8, with an average of 8.4 bucks, 21.6 does. Young rabbits formed 70.0% of the rabbit population. Owners of rabbitries usually cared for their animals as hired labour was expensive and often not available. High cost of feed was the most significant constraint to rabbit keeping, and mange was the most common disease affecting the rabbits. Marketing of rabbits was not organized, and this served as a disincentive to expanding the holdings. The rabbits were mostly sold either life or as fresh carcasses at the farm gate. To ensure a rapid growth of the rabbit industry, research should be undertaken to address the identified constraints to production while appropriate policies are put in place to enhance the growth of the industry

Safety of overlapping inpatient orthopaedic surgery: A multicenter study

BackgroundAlthough overlapping surgery is used to maximize efficiency, more empirical data are needed to guide patient safety. We conducted a retrospective cohort study to evaluate the safety of overlapping inpatient orthopaedic surgery, as judged by the occurrence of perioperative complications.MethodsAll inpatient orthopaedic surgical procedures performed at 5 academic institutions from January 1, 2015, to December 31, 2015, were included. Overlapping surgery was defined as 2 skin incisions open simultaneously for 1 surgeon. In comparing patients who underwent overlapping surgery with those who underwent non-overlapping surgery, the primary outcome was the occurrence of a perioperative complication within 30 days of the surgical procedure, and secondary outcomes included all-cause 30-day readmission, length of stay, and mortality. To determine if there was an association between overlapping surgery and a perioperative complication, we tested for non-inferiority of overlapping surgery, assuming a null hypothesis of an increased risk of 50%. We used an inverse probability of treatment weighted regression model adjusted for institution, procedure type, demographic characteristics (age, sex, race, comorbidities), admission type, admission severity of illness, and clustering by surgeon.ResultsAmong 14,135 cases, the frequency of overlapping surgery was 40%. The frequencies of perioperative complications were 1% in the overlapping surgery group and 2% in the non-overlapping surgery group. The overlapping surgery group was non-inferior to the non-overlapping surgery group (odds ratio [OR], 0.61 [90% confidence interval (CI), 0.45 to 0.83]; p < 0.001), with reduced odds of perioperative complications (OR, 0.61 [95% CI, 0.43 to 0.88]; p = 0.009). For secondary outcomes, there was a significantly lower chance of all-cause 30-day readmission in the overlapping surgery group (OR, 0.67 [95% CI, 0.52 to 0.87]; p = 0.003) and shorter length of stay (e, 0.94 [95% CI, 0.89 to 0.99]; p = 0.012). There was no difference in mortality.ConclusionsOur results suggest that overlapping inpatient orthopaedic surgery does not introduce additional perioperative risk for the complications that we evaluated. The suitability of this practice should be determined by individual surgeons on a case-by-case basis with appropriate informed consent.Level of evidenceTherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence

Inclusive production of a pair of hadrons separated by a large interval of rapidity in proton collisions

We consider within QCD collinear factorization the inclusive process $p+p\to h_1+h_2+X$, where the pair of identified hadrons, $h_1,h_2$, having large transverse momenta is produced in high-energy proton-proton collisions. In particular, we concentrate on the kinematics where the two identified hadrons in the final state are separated by a large interval of rapidity $\Delta y$. In this case the (calculable) hard part of the reaction receives large higher order corrections $\sim \alpha^n_s \Delta y^n$. We provide a theoretical input for the resummation of such contributions with next-to-leading logarithmic accuracy (NLA) in the BFKL approach. Specifically, we calculate in NLA the vertex (impact-factor) for the inclusive production of the identified hadron. This process has much in common with the widely discussed Mueller-Navelet jets production and can be also used to access the BFKL dynamics at proton colliders. Another application of the obtained identified-hadron vertex could be the NLA BFKL description of inclusive forward hadron production in DIS.Comment: 29 pages, 9 figures; corrected few typos and added an acknowledgment; version to be published on JHEP. arXiv admin note: substantial text overlap with arXiv:1202.108

High-efficiency Urban-traffic Management in Context-aware Computing and 5G Communication

With the increasing number of vehicle and traffic jams, urban-traffic management is becoming a serious issue. In this article, we propose novel four-tier architecture for urban-traffic management with the convergence of vehicle ad hoc networks (VANETs), 5G wireless network, software-defined network (SDN), and mobile-edge computing (MEC) technologies. The proposed architecture provides better communication and rapider responsive speed in a more distributed and dynamic manner. The practical case of rapid accident rescue can significantly cut down the time for rescue. Key technologies with respect to vehicle localization, data pre-fetching, traffic lights control, and traffic prediction are also discussed. Obviously, the novel architecture shows noteworthy potential for alleviating the traffic congestion and improving the efficiency of urban-traffic management

Investigation of Current Methods to Identify Helicopter Gear Health

This paper provides an overview of current vibration methods used to identify the health of helicopter transmission gears. The gears are critical to the transmission system that provides propulsion, lift and maneuvering of the helicopter. This paper reviews techniques used to process vibration data to calculate conditions indicators (CI's), guidelines used by the government aviation authorities in developing and certifying the Health and Usage Monitoring System (HUMS), condition and health indicators used in commercial HUMS, and different methods used to set thresholds to detect damage. Initial assessment of a method to set thresholds for vibration based condition indicators applied to flight and test rig data by evaluating differences in distributions between comparable transmissions are also discussed. Gear condition indicator FM4 values are compared on an OH58 helicopter during 14 maneuvers and an OH58 transmission test stand during crack propagation tests. Preliminary results show the distributions between healthy helicopter and rig data are comparable and distributions between healthy and damaged gears show significant differences

The next-to-leading order forward jet vertex in the small-cone approximation

We consider within QCD collinear factorization the process p+p to jet + jet +X, where two forward high-$p_T$ jets are produced with a large separation in rapidity $\Delta y$ (Mueller-Navelet jets). In this case the (calculable) hard part of the reaction receives large higher-order corrections $\sim \alpha^n_s (\Delta y)^n$, which can be accounted for in the BFKL approach. In particular, we calculate in the next-to-leading order the impact factor (vertex) for the production of a forward high-$p_T$ jet, in the approximation of small aperture of the jet cone in the pseudorapidity-azimuthal angle plane. The final expression for the vertex turns out to be simple and easy to implement in numerical calculations.Comment: 32 pages, 4 figures; a few comments and one reference added; a few inessential misprints removed; version to appear on JHE

A Survey of Satisfiability Modulo Theory

Satisfiability modulo theory (SMT) consists in testing the satisfiability of first-order formulas over linear integer or real arithmetic, or other theories. In this survey, we explain the combination of propositional satisfiability and decision procedures for conjunctions known as DPLL(T), and the alternative "natural domain" approaches. We also cover quantifiers, Craig interpolants, polynomial arithmetic, and how SMT solvers are used in automated software analysis.Comment: Computer Algebra in Scientific Computing, Sep 2016, Bucharest, Romania. 201

On relativization of the Sommerfeld-Gamow-Sakharov factor

The Sommerfeld-Gamow-Sakharov factor is considered for the general case of arbitrary masses and energies. It is shown that the scalar triangular one-loop diagram gives the Coulomb singularity in radiative corrections at the threshold. The singular part of the correction is factorized at the complete Born cross section regardless of its partial wave decomposition. Different approaches to generalize the factor are discussed.Comment: 9 pages, 4 figures; references and discussion are extende