Report from the first snake genomics and integrative biology meeting

Animal science

Detecting the Dependent Evolution of Biosequences

A probabilistic graphical model is developed in order to detect the dependent evolution between different sites in biological sequences. Given a multiple sequence alignment for each molecule of interest and a phylogenetic tree, the model can predict potential interactions within or between nucleic acids and proteins. Initial validation of the model is carried out using tRNA sequence data. The model is able to accurately identify the secondary structure of tRNA as well as several known tertiary interactions

The performance of missing transverse momentum reconstruction and its significance with the ATLAS detector using 140 fb-1 of √s = 13 TeV TeV pp collisions

Abstract This paper presents the reconstruction of missing transverse momentum ( $$p_{\text {T}}^{\text {miss}}$$ p T miss ) in proton–proton collisions, at a center-of-mass energy of 13 TeV. This is a challenging task involving many detector inputs, combining fully calibrated electrons, muons, photons, hadronically decaying $$\tau$$ τ -leptons, hadronic jets, and soft activity from remaining tracks. Possible double counting of momentum is avoided by applying a signal ambiguity resolution procedure which rejects detector inputs that have already been used. Several $$p_{\text {T}}^{\text {miss}}$$ p T miss ‘working points’ are defined with varying stringency of selections, the tightest improving the resolution at high pile-up by up to 39% compared to the loosest. The $$p_{\text {T}}^{\text {miss}}$$ p T miss performance is evaluated using data and Monte Carlo simulation, with an emphasis on understanding the impact of pile-up, primarily using events consistent with leptonic Z decays. The studies use $$140~\text {fb}^{-1}$$ 140 fb - 1 of data, collected by the ATLAS experiment at the Large Hadron Collider between 2015 and 2018. The results demonstrate that $$p_{\text {T}}^{\text {miss}}$$ p T miss reconstruction, and its associated significance, are well understood and reliably modelled by simulation. Finally, the systematic uncertainties on the soft $$p_{\text {T}}^{\text {miss}}$$ p T miss component are calculated. After various improvements the scale and resolution uncertainties are reduced by up to $$76\%$$ 76 % and $$51\%$$ 51 % , respectively, compared to the previous calculation at a lower luminosity

Improved reconstruction of highly boosted τ -lepton pairs in the τ τ → (μνμντ )(hadrons + ντ ) decay channels with the ATLAS detector

This paper presents a new τ -lepton reconstruction and identification procedure at the ATLAS detector at the Large Hadron Collider, which leads to significantly improved performance in the case of physics processes where a highly boosted pair of τ -leptons is produced and one τ -lepton decays into a muon and two neutrinos (τμ), and the other decays into hadrons and one neutrino (τhad). By removing the muon information from the signals used for reconstruction and identification of the τhad candidate in the boosted pair, the efficiency is raised to the level expected for an isolated τhad. The new procedure is validated by selecting a sample of highly boosted Z → τμτhad candidates from the data sample of 140 fb−1 of proton–proton collisions at 13 TeV recorded with the ATLAS detector. Good agreement is found between data and simulation predictions in both the Z → τμτhad signal region and in a background validation region. The results presented in this paper demonstrate the effectiveness of the τhad reconstruction with muon removal in enhancing the signal sensitivity of the boosted τμτhad channel at the ATLAS detector

Reconstruction and identification of pairs of collimated τ-leptons decaying hadronically using sqrt{s}=13 TeV pp collision data with the ATLAS detector

This paper describes an algorithm for reconstructing and identifying a highly collimated hadronically decaying τ -lepton pair with low transverse momentum. When two τ -leptons are highly collimated, their visible decay products might overlap, degrading the reconstruction performance for each of the τ -leptons. A dedicated treatment attempting to tag the τ -lepton pair as a single object is required. The reconstruction algorithm is based on a large radius jet and its associated two leading subjets, and the identification uses a boosted decision tree to discriminate between signatures from τ +τ − systems and those arising from QCD jets. The efficiency of the identification algorithm is measured in Zγ events using proton–proton collision data at √s = 13 TeV collected by the ATLAS experiment at the Large Hadron Collider between 2015 and 2018, corresponding to an integrated luminosity of 139 fb−1. The resulting data-to-simulation scale factors are close to unity with uncertainties ranging from 26 to 37%

Cross-section measurements for the production of a W-boson in association with high-transverse-momentum jets in pp collisions at √s = 13 TeV with the ATLAS detector

A set of measurements for the production of a W-boson in association with high-transverse-momentum jets is presented using 140 fb−1 of proton–proton collision data at a centre-of-mass energy of √s = 13 TeV collected by the ATLAS detector at the LHC. The measurements are performed in final states in which the W-boson decays into an electron or muon plus a neutrino and is produced in association with jets with pT > 30 GeV, where the leading jet has pT > 500 GeV. The angular separation between the lepton and the closest jet with pT > 100 GeV is measured and used to define a collinear phase space, wherein measurements of kinematic properties of the W-boson and the associated jet are performed. The collinear phase space is populated by dijet events radiating a W-boson and events with a W-boson produced in association with several jets and it serves as an excellent data sample to probe higher-order theoretical predictions. Measured differential distributions are compared with predictions from state-of-the-art next-to-leading order multi-leg merged Monte Carlo event generators and a fixedorder calculation of the W +1-jet process computed at nextto-next-to-leading order in the strong coupling constant