An Electron Paramagnetic Resonance (EPR) spectroscopy study on the γ-irradiation sterilization of the pharmaceutical excipient l-histidine: Regeneration of the radicals in solution

The effects of γ-radiation sterilization on the parenteral excipient L-histidine were analysed by means of EPR spectroscopy. The irradiation process was found to induce the formation of a deamination radical which was persistent in the solid state. The nature and reactivity of the radicals following dissolution in water was evaluated using spin-trapping EPR experiments. The deamination radical was found to regenerate in solution in the presence of trace metals, potentially leading to radical induced degradation reactions occurring up to an hour after the dissolution process. Understanding this process is significant for the improved design of parental pharmaceutical formulations in which unwanted radical reactions after γ radiation sterilization could lead to degradation of active ingredients

Very high energy observations of the BL Lac objects 3C 66A and OJ 287

Using the Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE), we have observed the BL Lac objects 3C 66A and OJ 287. These are members of the class of low-frequency-peaked BL Lac objects (LBLs) and are two of the three LBLs predicted by Costamante and Ghisellini to be potential sources of very high energy (>100 GeV) gamma-ray emission. The third candidate, BL Lacertae, has recently been detected by the MAGIC collaboration. Our observations have not produced detections; we calculate a 99% CL upper limit of flux from 3C 66A of 0.15 Crab flux units and from OJ 287 our limit is 0.52 Crab. These limits assume a Crab-like energy spectrum with an effective energy threshold of 185 GeV.Comment: 24 pages, 15 figures, Accepted for publication in Astroparticle Physic

Perspectives in visual imaging for marine biology and ecology: from acquisition to understanding

Durden J, Schoening T, Althaus F, et al. Perspectives in Visual Imaging for Marine Biology and Ecology: From Acquisition to Understanding. In: Hughes RN, Hughes DJ, Smith IP, Dale AC, eds. Oceanography and Marine Biology: An Annual Review. 54. Boca Raton: CRC Press; 2016: 1-72

Prevalence of radio jets associated with galactic outflows and feedback from quasars

We present 1–7 GHz high-resolution radio imaging (VLA and e-MERLIN) and spatially-resolved ionized gas kinematics for ten z<0.2 type 2 ‘obscured’ quasars (log [LAGN/erg s−1]≳45) with moderate radio luminosities (log [L1.4 GHz/W Hz−1]=23.3–24.4). These targets were selected to have known ionized outflows based on broad [O iii] emission-line components (FWHM≈800–1800 km s−1). Although ‘radio-quiet’ and not ‘radio AGN’ by many traditional criteria, we show that for nine of the targets, star formation likely accounts for ≲10 per cent of the radio emission. We find that ∼80–90 per cent of these nine targets exhibit extended radio structures on 1–25 kpc scales. The quasars’ radio morphologies, spectral indices and position on the radio size-luminosity relationship reveals that these sources are consistent with being low power compact radio galaxies. Therefore, we favour radio jets as dominating the radio emission in the majority of these quasars. The radio jets we observe are associated with morphologically and kinematically distinct features in the ionized gas, such as increased turbulence and outflowing bubbles, revealing jet-gas interaction on galactic scales. Importantly, such conclusions could not have been drawn from current low-resolution radio surveys such as FIRST. Our observations support a scenario where compact radio jets, with modest radio luminosities, are a crucial feedback mechanism for massive galaxies during a quasar phase

The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review

Objectives: Inflammatory Breast cancer (IBC) is a rare but aggressive form of breast cancer. Its incidence and behaviour in the UK is poorly characterised. We collected retrospective data from hospitals in the UK and Ireland to describe the presentation, pathology, treatment and clinical course of IBC in the UK. Materials and methods: Patients with IBC diagnosed between 1997–2014 at fourteen UK and Irish hospitals were identified from local breast unit databases. Patient characteristics, tumour pathology and stage, and details of surgical, systemic and radiotherapy treatment and follow-up data were collected from electronic patient records and medical notes. Result: This retrospective review identified 445 patients with IBC accounting for 0.4–1.8% of invasive breast cancer cases. Median follow-up was 4.2 years. 53.2% of tumours were grade 3, 56.2% were oestrogen receptor positive, 31.3% were HER2 positive and 25.1% were triple negative. 20.7% of patients had distant metastases at presentation. Despite trimodality treatment in 86.4%, 40.1% of stage III patients developed distant metastases. Five-year overall survival (OS) was 61.0% for stage III and 21.4% for stage IV patients. Conclusions: This is the largest series of UK IBC patients reported to date. It indicates a lower incidence than in American series, but confirms that IBC has a high risk of recurrence with poor survival despite contemporary multi-modality therapy. A national strategy is required to facilitate translational research into this aggressive disease

KILOPARSEC-SCALE DUST DISKS IN HIGH-REDSHIFT LUMINOUS SUBMILLIMETER GALAXIES

We present high-resolution (0farcs16) 870 μm Atacama Large Millimeter/submillimeter Array (ALMA) imaging of 16 luminous (${L}_{\mathrm{IR}}\sim 4\times {10}^{12}\,{L}_{\odot }$) submillimeter galaxies (SMGs) from the ALESS survey of the Extended Chandra Deep Field South. This dust imaging traces the dust-obscured star formation in these $z\sim 2.5$ galaxies on ~1.3 kpc scales. The emission has a median effective radius of R e = 0farcs24 ± 0farcs02, corresponding to a typical physical size of ${R}_{e}=$ 1.8 ± 0.2 kpc. We derive a median Sérsic index of n = 0.9 ± 0.2, implying that the dust emission is remarkably disk-like at the current resolution and sensitivity. We use different weighting schemes with the visibilities to search for clumps on 0farcs12 (~1.0 kpc) scales, but we find no significant evidence for clumping in the majority of cases. Indeed, we demonstrate using simulations that the observed morphologies are generally consistent with smooth exponential disks, suggesting that caution should be exercised when identifying candidate clumps in even moderate signal-to-noise ratio interferometric data. We compare our maps to comparable-resolution Hubble Space Telescope ${H}_{160}$-band images, finding that the stellar morphologies appear significantly more extended and disturbed, and suggesting that major mergers may be responsible for driving the formation of the compact dust disks we observe. The stark contrast between the obscured and unobscured morphologies may also have implications for SED fitting routines that assume the dust is co-located with the optical/near-IR continuum emission. Finally, we discuss the potential of the current bursts of star formation to transform the observed galaxy sizes and light profiles, showing that the $z\sim 0$ descendants of these SMGs are expected to have stellar masses, effective radii, and gas surface densities consistent with the most compact massive (${M}_{* }\,\sim$ 1–2 × 1011 ${M}_{\odot }$) early-type galaxies observed locally

A re-examination of early sodium-water reaction experiments in the context of Design Basis Accidents

SIGLEAvailable from British Library Document Supply Centre- DSC:9091.9F(ND-R--1265(D)) / BLDSC - British Library Document Supply CentreGBUnited Kingdo