Fractal Descriptors in the Fourier Domain Applied to Color Texture Analysis

The present work proposes the development of a novel method to provide descriptors for colored texture images. The method consists in two steps. In the first, we apply a linear transform in the color space of the image aiming at highlighting spatial structuring relations among the color of pixels. In a second moment, we apply a multiscale approach to the calculus of fractal dimension based on Fourier transform. From this multiscale operation, we extract the descriptors used to discriminate the texture represented in digital images. The accuracy of the method is verified in the classification of two color texture datasets, by comparing the performance of the proposed technique to other classical and state-of-the-art methods for color texture analysis. The results showed an advantage of almost 3% of the proposed technique over the second best approach.Comment: Chaos, Volume 21, Issue 4, 201

Negative phenotypic and genetic associations between copulation duration and longevity in male seed beetles

Reproduction can be costly and is predicted to trade-off against other characters. However, while these trade-offs are well documented for females, there has been less focus on aspects of male reproduction. Furthermore, those studies that have looked at males typically only investigate phenotypic associations, with the underlying genetics often ignored. Here, we report on phenotypic and genetic trade-offs in male reproductive effort in the seed beetle, Callosobruchus maculatus. We find that the duration of a male's first copulation is negatively associated with subsequent male survival, phenotypically and genetically. Our results are consistent with life-history theory and suggest that like females, males trade-off reproductive effort against longevity

Regularity of the Solutions to SPDEs in Metric Measure Spaces

In this paper we study the regularity of non-linear parabolic PDEs and stochastic PDEs on metric measure spaces admitting heat kernel estimates. In particular we consider mild function solutions to abstract Cauchy problems and show that the unique solution is Hölder continuous in time with values in a suitable fractional Sobolev space. As this analysis is done via a-priori estimates, we can apply this result to stochastic PDEs on metric measure spaces and solve the equation in a pathwise sense for almost all paths. The main example of noise term is of fractional Brownian type and the metric measure spaces can be classical as well as given by various fractal structures. The whole approach is low dimensional and works for spectral dimensions less than 4

Sexual selection protects against extinction

Reproduction through sex carries substantial costs, mainly because only half of sexual adults produce offspring. It has been theorised that these costs could be countered if sex allows sexual selection to clear the universal fitness constraint of mutation load. Under sexual selection, competition between (usually) males, and mate choice by (usually) females create important intraspecific filters for reproductive success, so that only a subset of males gains paternity. If reproductive success under sexual selection is dependent on individual condition, which depends on mutation load, then sexually selected filtering through ‘genic capture’ could offset the costs of sex because it provides genetic benefits to populations. Here, we test this theory experimentally by comparing whether populations with histories of strong versus weak sexual selection purge mutation load and resist extinction differently. After evolving replicate populations of the flour beetle Tribolium castaneum for ~7 years under conditions that differed solely in the strengths of sexual selection, we revealed mutation load using inbreeding. Lineages from populations that had previously experienced strong sexual selection were resilient to extinction and maintained fitness under inbreeding, with some families continuing to survive after 20 generations of sib × sib mating. By contrast, lineages derived from populations that experienced weak or non-existent sexual selection showed rapid fitness declines under inbreeding, and all were extinct after generation 10. Multiple mutations across the genome with individually small effects can be difficult to clear, yet sum to a significant fitness load; our findings reveal that sexual selection reduces this load, improving population viability in the face of genetic stress

Scale-invariance of galaxy clustering

Some years ago we proposed a new approach to the analysis of galaxy and cluster correlations based on the concepts and methods of modern statistical Physics. This led to the surprising result that galaxy correlations are fractal and not homogeneous up to the limits of the available catalogs. The usual statistical methods, which are based on the assumption of homogeneity, are therefore inconsistent for all the length scales probed so far, and a new, more general, conceptual framework is necessary to identifythe real physical properties of these structures. In the last few years the 3-d catalogs have been significatively improved and we have extended our methods to the analysis of number counts and angular catalogs. This has led to a complete analysis of all the available data that we present in this review. The result is that galaxy structures are highly irregular and self-similar: all the available data are consistent with each other and show fractal correlations (with dimension $D \simeq 2$) up to the deepest scales probed so far (1000 \hmp) and even more as indicated from the new interpretation of the number counts. The evidence for scale-invariance of galaxy clustering is very strong up to 150 \hmp due to the statistical robustness of the data but becomes progressively weaker (statistically) at larger distances due to the limited data. In These facts lead to fascinating conceptual implications about our knowledge of the universe and to a new scenario for the theoretical challenge in this field.Comment: Latex file 165 pages, 106 postscript figures. This paper is also available at http://www.phys.uniroma1.it/DOCS/PIL/pil.html To appear in Physics Report (Dec. 1997

Assessing the clinical utility of cancer genomic and proteomic data across tumor types

Molecular profiling of tumors promises to advance the clinical management of cancer, but the benefits of integrating molecular data with traditional clinical variables have not been systematically studied. Here we retrospectively predict patient survival using diverse molecular data (somatic copy-number alteration, DNA methylation and mRNA, miRNA and protein expression) from 953 samples of four cancer types from The Cancer Genome Atlas project. We found that incorporating molecular data with clinical variables yielded statistically significantly improved predictions (FDR < 0.05) for three cancers but those quantitative gains were limited (2.2–23.9%). Additional analyses revealed little predictive power across tumor types except for one case. In clinically relevant genes, we identified 10,281 somatic alterations across 12 cancer types in 2,928 of 3,277 patients (89.4%), many of which would not be revealed in single-tumor analyses. Our study provides a starting point and resources, including an open-access model evaluation platform, for building reliable prognostic and therapeutic strategies that incorporate molecular data

A Two-sided Loop X-Ray Solar Coronal Jet Driven by a Minifilament Eruption

Most of the commonly discussed solar coronal jets are the type that consist of a single spire extending approximately vertically from near the solar surface into the corona. Recent research supports that eruption of a miniature filament (minifilament) drives many such single-spire jets and concurrently generates a miniflare at the eruption site. A different type of coronal jet, identified in X-ray images during the Yohkoh era, are two-sided loop jets, which extend from a central excitation location in opposite directions, along low-lying coronal loops that are more-or-less horizontal to the surface. We observe such a two-sided loop jet from the edge of active region (AR) 12473, using data from Hinode X-Ray Telescope (XRT) and Extreme Ultraviolet Imaging Spectrometer (EIS), and from Solar Dynamics Observatory's (SDO) Atmospheric Imaging Assembly (AIA) and Helioseismic and Magnetic Imager (HMI). Similar to single-spire jets, this two-sided loop jet results from eruption of a minifilament, which accelerates to over 140 km s−1 before abruptly stopping after striking an overlying nearly horizontal-loop field at ~30,000 km in altitude and producing the two-sided loop jet. An analysis of EIS raster scans shows that a hot brightening, consistent with a small flare, develops in the aftermath of the eruption, and that Doppler motions (~40 km s−1) occur near the jet formation region. As with many single-spire jets, the magnetic trigger here is apparently flux cancelation, which occurs at a rate of ~4 × 1018 Mx hr−1, broadly similar to the rates observed in some single-spire quiet-Sun and AR jets. An apparent increase in the (line-of-sight) flux occurs within minutes of the onset of the minifilament eruption, consistent with the apparent increase being due to a rapid reconfiguration of low-lying fields during and soon after the minifilament-eruption onset

Febrile seizures and mechanisms of epileptogenesis: insights from an animal model.

Temporal lobe epilepsy (TLE) is the most prevalent type of human epilepsy, yet the causes for its development, and the processes involved, are not known. Most individuals with TLE do not have a family history, suggesting that this limbic epilepsy is a consequence of acquired rather than genetic causes. Among suspected etiologies, febrile seizures have frequently been cited. This is due to the fact that retrospective analyses of adults with TLE have demonstrated a high prevalence (20--&gt;60%) of a history of prolonged febrile seizures during early childhood, suggesting an etiological role for these seizures in the development of TLE. Specifically, neuronal damage induced by febrile seizures has been suggested as a mechanism for the development of mesial temporal sclerosis, the pathological hallmark of TLE. However, the statistical correlation between febrile seizures and TLE does not necessarily indicate a causal relationship. For example, preexisting (genetic or acquired) 'causes' that result independently in febrile seizures and in TLE would also result in tight statistical correlation. For obvious reasons, complex febrile seizures cannot be induced in the human, and studies of their mechanisms and of their consequences on brain molecules and circuits are severely limited. Therefore, an animal model was designed to study these seizures. The model reproduces the fundamental key elements of the human condition: the age specificity, the physiological temperatures seen in fevers of children, the length of the seizures and their lack of immediate morbidity. Neuroanatomical, molecular and functional methods have been used in this model to determine the consequences of prolonged febrile seizures on the survival and integrity of neurons, and on hyperexcitability in the hippocampal-limbic network. Experimental prolonged febrile seizures did not lead to death of any of the seizure-vulnerable populations in hippocampus, and the rate of neurogenesis was also unchanged. Neuronal function was altered sufficiently to promote synaptic reorganization of granule cells, and transient and long-term alterations in the expression of specific genes were observed. The contribution of these consequences of febrile seizures to the epileptogenic process is discussed

SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis

\ua9 2024Serine proteinase inhibitors (serpins) are a family of structurally similar proteins which regulate many diverse biological processes from blood coagulation to extracellular matrix (ECM) remodelling. Chondrogenesis involves the condensation and differentiation of mesenchymal stem cells (MSCs) into chondrocytes which occurs during early development. Here, and for the first time, we demonstrate that one serpin, SERPINA3 (gene name SERPINA3, protein also known as alpha-1 antichymotrypsin), plays a critical role in chondrogenic differentiation. We observed that SERPINA3 expression was markedly induced at early time points during in vitro chondrogenesis. We examined the expression of SERPINA3 in human cartilage development, identifying significant enrichment of SERPINA3 in developing cartilage compared to total limb, which correlated with well-described markers of cartilage differentiation. When SERPINA3 was silenced using siRNA, cartilage pellets were smaller and contained lower proteoglycan as determined by dimethyl methylene blue assay (DMMB) and safranin-O staining. Consistent with this, RNA sequencing revealed significant downregulation of genes associated with cartilage ECM formation perturbing chondrogenesis. Conversely, SERPINA3 silencing had a negligible effect on the gene expression profile during osteogenesis suggesting the role of SERPINA3 is specific to chondrocyte differentiation. The global effect on cartilage formation led us to investigate the effect of SERPINA3 silencing on the master transcriptional regulator of chondrogenesis, SOX9. Indeed, we observed that SOX9 protein levels were markedly reduced at early time points suggesting a role for SERPINA3 in regulating SOX9 expression and activity. In summary, our data support a non-redundant role for SERPINA3 in enabling chondrogenesis via regulation of SOX9 levels