The heating of dust by old stellar populations in the Bulge of M31

We use new Herschel multi-band imaging of the Andromeda galaxy to analyze how dust heating occurs in the central regions of galaxy spheroids that are essentially devoid of young stars. We construct a dust temperature map of M31 through fitting modified blackbody SEDs to the Herschel data, and find that the temperature within 2 kpc rises strongly from the mean value in the disk of 17 pm 1K to \sim35K at the centre. UV to near-IR imaging of the central few kpc shows directly the absence of young stellar populations, delineates the radial profile of the stellar density, and demonstrates that even the near-UV dust extinction is optically thin in M31's bulge. This allows the direct calculation of the stellar radiation heating in the bulge, U\ast(r), as a function of radius. The increasing temperature profile in the centre matches that expected from the stellar heating, i.e. that the dust heating and cooling rates track each other over nearly two orders of magnitude in U\ast. The modelled dust heating is in excess of the observed dust temperatures, suggesting that it is more than sufficient to explain the observed IR emission. Together with the wavelength dependent absorption cross section of the dust, this demonstrates directly that it is the optical, not UV, radiation that sets the heating rate. This analysis shows that neither young stellar populations nor stellar near-UV radiation are necessary to heat dust to warm temperatures in galaxy spheroids. Rather, it is the high densities of Gyr-old stellar populations that provide a sufficiently strong diffuse radiation field to heat the dust. To the extent which these results pertain to the tenuous dust found in the centres of early-type galaxies remains yet to be explored.Comment: 11 pages. Accepted for publication in MNRA

Symmetry energy of dense matter in holographic QCD

We study the nuclear symmetry energy of dense matter using holographic QCD. To this end, we consider two flavor branes with equal quark masses in a D4/D6/D6 model. We find that at all densities the symmetry energy monotonically increases. At small densities, it exhibits a power law behavior with the density, $E_{\rm sym} \sim \rho^{1/2}$.Comment: 9 pages, 3 figure

The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes

Context: Obesity-associated inflammation is a contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM); the mechanisms underlying the progression to T2DM are unclear. The adipokine resistin has demonstrated pro-inflammatory properties in relation to obesity and T2DM. Objective: To characterize resistin expression in human obesity and address the role of resistin in the innate immune pathway. Furthermore, examine the influence of lipopolysaccharide, recombinant human resistin (rhResistin), insulin and rosiglitazone in human adipocytes. Finally, analyze the effect of rhResistin on the expression of components of the NF-κB pathway and insulin signaling cascade. Methods: Abdominal subcutaneous adipose tissue was obtained from patients undergoing elective liposuction surgery (n = 35, aged: 36-49 yr; BMI: 26.5 ± 5.9 kg/m2). Isolated adipocytes were cultured with rhResistin (10-50 ng/ml). The level of cytokine secretion from isolated adipocytes was examined by ELISA. The effect of rhResistin on protein expression of components of the innate immune pathway was examined by Western blot. Results: In-vitro studies demonstrated that antigenic stimuli increase resistin secretion (P < 0.001) from isolated adipocytes. Pro-inflammatory cytokine levels were increased in response to rhResistin (P < 0.001); this was attenuated by rosiglitazone (P < 0.01). When examining components of the innate immune pathway, rhResistin stimulated Toll-like receptor-2 protein expression. Similarly, mediators of the insulin signaling pathway, phosphospecific JNK1 and JNK2, were upregulated in response to rhResistin. Conclusion: Resistin may participate in more than one mechanism to influence pro-inflammatory cytokine release from human adipocytes; potentially via the integration of NF-κB and JNK signaling pathways

Cosmological Implications of a Stellar Initial Mass Function that Varies with the Jeans Mass in Galaxies

Observations of star-forming galaxies at high-z have suggested discrepancies in the inferred star formation rates (SFRs) either between data and models, or between complementary measures of the SFR. These putative discrepancies could all be alleviated if the stellar IMF is systematically weighted toward more high-mass star formation in rapidly star-forming galaxies. Here, we explore how the IMF might vary under the central assumption that the turnover mass in the IMF, Mc, scales with the Jeans mass in giant molecular clouds (GMCs), M_J. We employ hydrodynamic and radiative transfer simulations of galaxies to predict how the typical GMC Jeans mass, and hence the IMF, varies with galaxy property. We then study the impact of such an IMF on the star formation law, the SFR-M* relation, submillimetre galaxies (SMGs), and the cosmic SFR density. Our main results are: The H2 mass-weighted Jeans mass in a galaxy scales with the SFR when the SFR is greater a few M_sun/yr. SPS modeling shows that this results in a nonlinear relation between SFR and Lbol, such that SFR Lbol^0.88. Using this model relation, the inferred SFR of local ULIRGs decreases by ~2, and that of high-z SMGs decreases by ~3-5. At z 2, this results in a lowered normalisation of the SFR-M* relation in better agreement with models, a reduced discrepancy between the observed cosmic SFR density and stellar mass density evolution, and SMG SFRs that are easier to accommodate in current hierarchical structure formation models. It further results in a Schmidt relation with slope of ~1.6 when utilising a physically motivated form for the CO-H2 conversion factor. While each of the discrepancies considered here could be alleviated without appealing to a varying IMF, the modest variation implied by assuming Mc M_J is a plausible solution that simultaneously addresses numerous thorny issues regarding the SFRs of high-z galaxies.Comment: MNRAS Accepted; 16 page

How to distinguish starbursts and quiescently star-forming galaxies: The `bimodal' submillimetre galaxy population as a case study

In recent work (arXiv:1101.0002) we have suggested that the high-redshift (z ~ 2-4) bright submillimetre galaxy (SMG) population is heterogeneous, with major mergers contributing both at early stages, where quiescently star-forming discs are blended into one submm source (`galaxy-pair SMGs'), and late stages, where mutual tidal torques drive gas inflows and cause strong starbursts. Here we combine hydrodynamic simulations of major mergers with 3-D dust radiative transfer calculations to determine observational diagnostics that can distinguish between quiescently star-forming SMGs and starburst SMGs via integrated data alone. We fit the far-IR SEDs of the simulated galaxies with the optically thin single-temperature modified blackbody, the full form of the single-temperature modified blackbody, and a power-law temperature-distribution model. The effective dust temperature, T_dust, and power-law index of the dust emissivity in the far-IR, \beta, derived can significantly depend on the fitting form used, and the intrinsic \beta\ of the dust is not recovered. However, for all forms used here, there is a T_dust above which almost all simulated galaxies are starbursts, so a T_dust cut is very effective at selecting starbursts. Simulated merger-induced starbursts also have higher L_IR/M_gas and L_IR/L_FUV than quiescently star-forming galaxies and lie above the star formation rate-stellar mass relation. These diagnostics can be used to test our claim that the SMG population is heterogeneous and to observationally determine what star formation mode dominates a given galaxy population. We comment on applicability of these diagnostics to ULIRGs that would not be selected as SMGs. These `hot-dust ULIRGs' are typically starburst galaxies lower in mass than SMGs, but they can also simply be SMGs observed from a different viewing angle.Comment: 21 pages, 11 figures. Accepted for publication in MNRAS. Minor changes to text but otherwise identical to v

Functional similarities between pigeon \u27milk\u27 and mammalian milk : induction of immune gene expression and modification of the microbiota

Pigeon &lsquo;milk&rsquo; and mammalian milk have functional similarities in terms of nutritional benefit and delivery of immunoglobulins to the young. Mammalian milk has been clearly shown to aid in the development of the immune system and microbiota of the young, but similar effects have not yet been attributed to pigeon &lsquo;milk&rsquo;. Therefore, using a chicken model, we investigated the effect of pigeon &lsquo;milk&rsquo; on immune gene expression in the Gut Associated Lymphoid Tissue (GALT) and on the composition of the caecal microbiota. Chickens fed pigeon &lsquo;milk&rsquo; had a faster rate of growth and a better feed conversion ratio than control chickens. There was significantly enhanced expression of immune-related gene pathways and interferon-stimulated genes in the GALT of pigeon &lsquo;milk&rsquo;-fed chickens. These pathways include the innate immune response, regulation of cytokine production and regulation of B cell activation and proliferation. The caecal microbiota of pigeon &lsquo;milk&rsquo;-fed chickens was significantly more diverse than control chickens, and appears to be affected by prebiotics in pigeon &lsquo;milk&rsquo;, as well as being directly seeded by bacteria present in pigeon &lsquo;milk&rsquo;. Our results demonstrate that pigeon &lsquo;milk&rsquo; has further modes of action which make it functionally similar to mammalian milk. We hypothesise that pigeon &lsquo;lactation&rsquo; and mammalian lactation evolved independently but resulted in similarly functional products

Pregnancy, prescription medicines and the potential risk of herb-drug interactions:a cross-sectional survey

Funding All funding was from institutional resource. JSM, AS are employed by the University of Aberdeen. DS is employed by the Robert Gordon University. BP and CR are employed by NHS Scotland. ARP and MAH are employed by the Hamad Medical Corporation. Qatar. NI is a postgraduate student at the University of Aberdeen.Peer reviewedPublisher PD

'Asking the right question'. A comparison of two approaches to gathering data on 'herbals' use in survey based studies

BACKGROUND:Over the last decade academic interest in the prevalence and nature of herbal medicines use by pregnant women has increased significantly. Such data are usually collected by means of an administered questionnaire survey, however a key methodological limitation using this approach is the need to clearly define the scope of 'herbals' to be investigated. The majority of published studies in this area neither define 'herbals' nor provide a detailed checklist naming specific 'herbals' and CAM modalities, which limits inter-study comparison, generalisability and the potential for meta-analyses. The aim of this study was to compare the self-reported use of herbs, herbal medicines and herbal products using two different approaches implemented in succession. METHODS:Cross-sectional questionnaire surveys of women attending for their mid-trimester scan or attending the postnatal unit following live birth at the Royal Aberdeen Maternity Hospital, North-East Scotland. The questionnaire utilised two approaches to collect data on 'herbals' use, a single closed yes/no answer to the question "have you used herbs, herbal medicines and herbal products in the last three months"; and a request to tick which of a list of 40 'herbals' they had used in the same time period. RESULTS:A total of 889 responses were obtained of which 4.3% (38) answered 'yes' to herbal use via the closed question. However, using the checklist 39% (350) of respondents reported the use of one or more specific 'herbals' (p<0.0001). The 312 respondents who reported 'no' to 'herbals' use via the closed question but "yes" via the checklist consumed a total of 20 different 'herbals' (median 1, interquartile range 1-2, range 1-6). CONCLUSIONS:This study demonstrates that the use of a single closed question asking about the use of 'herbals', as frequently reported in published studies, may not yield valid data resulting in a gross underestimation of actual use