Cartan subalgebras in C*-algebras of Hausdorff etale groupoids

The reduced $C^*$-algebra of the interior of the isotropy in any Hausdorff \'etale groupoid $G$ embeds as a $C^*$-subalgebra $M$ of the reduced $C^*$-algebra of $G$. We prove that the set of pure states of $M$ with unique extension is dense, and deduce that any representation of the reduced $C^*$-algebra of $G$ that is injective on $M$ is faithful. We prove that there is a conditional expectation from the reduced $C^*$-algebra of $G$ onto $M$ if and only if the interior of the isotropy in $G$ is closed. Using this, we prove that when the interior of the isotropy is abelian and closed, $M$ is a Cartan subalgebra. We prove that for a large class of groupoids $G$ with abelian isotropy---including all Deaconu--Renault groupoids associated to discrete abelian groups---$M$ is a maximal abelian subalgebra. In the specific case of $k$-graph groupoids, we deduce that $M$ is always maximal abelian, but show by example that it is not always Cartan.Comment: 14 pages. v2: Theorem 3.1 in v1 incorrect (thanks to A. Kumjain for pointing out the error); v2 shows there is a conditional expectation onto $M$ iff the interior of the isotropy is closed. v3: Material (including some theorem statements) rearranged and shortened. Lemma~3.5 of v2 removed. This version published in Integral Equations and Operator Theor

Nonlinearity effects in the kicked oscillator

The quantum kicked oscillator is known to display a remarkable richness of dynamical behaviour, from ballistic spreading to dynamical localization. Here we investigate the effects of a Gross Pitaevskii nonlinearity on quantum motion, and provide evidence that the qualitative features depend strongly on the parameters of the system.Comment: 4 pages, 5 figure

Metallicity structure in the Milky Way disk revealed by Galactic H II regions

The metallicity structure of the Milky Way disk stems from the chemodynamical evolutionary history of the Galaxy. We use the National Radio Astronomy Observatory Karl G. Jansky Very Large Array to observe ∼8–10 GHz hydrogen radio recombination line and radio-continuum emission toward 82 Galactic H ii regions. We use these data to derive the electron temperatures and metallicities for these nebulae. Since collisionally excited lines from metals (e.g., oxygen, nitrogen) are the dominant cooling mechanism in H ii regions, the nebular metallicity can be inferred from the electron temperature. Including previous single-dish studies, there are now 167 nebulae with radio-determined electron temperature and either parallax or kinematic distance determinations. The interferometric electron temperatures are systematically 10% larger than those found in previous single-dish studies, likely due to incorrect data analysis strategies, optical depth effects, and/or the observation of different gas by the interferometer. By combining the interferometer and single-dish samples, we find an oxygen abundance gradient across the Milky Way disk with a slope of −0.052 ± 0.004 dex kpc−1. We also find significant azimuthal structure in the metallicity distribution. The slope of the oxygen gradient varies by a factor of ∼2 when Galactocentric azimuths near ∼30° are compared with those near ∼100°. This azimuthal structure is consistent with simulations of Galactic chemodynamical evolution influenced by spiral arms.First author draf

Optimisations and challenges involved in the creation of various bioluminescent and fluorescent influenza a virus strains for in vitro and in vivo applications

Bioluminescent and fluorescent influenza A viruses offer new opportunities to study influenza virus replication, tropism and pathogenesis. To date, several influenza A reporter viruses have been described. These strategies typically focused on a single reporter gene (either bioluminescent or fluorescent) in a single virus backbone. However, whilst bioluminescence is suited to in vivo imaging, fluorescent viruses are more appropriate for microscopy. Therefore, the idea l reporter virus varies depending on the experiment in question, and it is important that any reporter virus strategy can be adapted accordingly. Herein, a strategy was developed to create five different reporter viruses in a single virus backbone. Specifically, enhanced green fluorescent protein (eGFP), far-red fluorescent protein (fRFP), near-infrared fluorescent protein (iRFP), Gaussia luciferase (gLUC) and firefly luciferase (fLUC) were inserted into the PA gene segment of A/PR/8/34 (H1N1). This study provides a comprehensive characterisation of the effects of different reporter genes on influenza virus replication and reporter activity. In vivo reporter gene expression, in lung tissues, was only detected for eGFP, fRFP and gLUC expressing viruses. In vitro, the eGFP-expressing virus displayed the best reporter stability and could be used for correlative light electron microscopy (CLEM). This strategy was then used to create eGFP-expressing viruses consisting entirely of pandemic H1N1, highly pathogenic avian influenza (HPAI) H5N1 and H7N9. The HPAI H5N1 eGFP-expressing virus infected mice and reporter gene expression was detected, in lung tissues, in vivo. Thus, this study provides new tools and insights for the creation of bioluminescent and fluorescent influenza A reporter viruses. Copyright

Science with an ngVLA: radio recombination lines from HII regions

The ngVLA will create a Galaxy-wide, volume-limited sample of HII regions; solve some long standing problems in the physics of HII regions; and provide an extinction-free star formation tracer in nearby galaxies.First author draf

A Galactic plane defined by the Milky Way H II region distribution

We develop a framework for a new definition of the Galactic midplane, allowing for tilt theta_tilt; rotation about Galactic azimuth 90°) and roll (theta_roll; rotation about Galactic azimuth 0°) of the midplane with respect to the current definition. Derivation of the tilt and roll angles also determines the solar height above the midplane. Here we use nebulae from the Wide-field Infrared Survey Explorer (WISE) Catalog of Galactic H ii Regions to define the Galactic high-mass star formation (HMSF) midplane. We analyze various subsamples of the WISE catalog and find that all have Galactic latitude scale heights near 0.°30 and z-distribution scale heights near 30 pc. The vertical distribution for small (presumably young) H ii regions is narrower than that of larger (presumably old) H ii regions (∼25 p versus ∼40 pc ), implying that the larger regions have migrated further from their birth sites. For all H ii region subsamples and for a variety of fitting methodologies, we find that the HMSF midplane is not significantly tilted or rolled with respect to the currently defined midplane, and, therefore, the Sun is near to the HMSF midplane. These results are consistent with other studies of HMSF, but are inconsistent with many stellar studies, perhaps because of asymmetries in the stellar distribution near the Sun. Our results are sensitive to latitude restrictions and also to the completeness of the sample, indicating that similar analyses cannot be done accurately with less complete samples. The midplane framework we develop can be used for any future sample of Galactic objects to redefine the midplane.This work is supported by NSF grant No. AST1516021 to L.D.A. T.M.B. acknowledges support from NSF grant No. AST 1714688. Support for T.V.W. was provided by the NSF through the Grote Reber Fellowship Program administered by Associated Universities, Inc./National Radio Astronomy Observatory. We thank Bob Benjamin for enlightening discussions on early drafts of this manuscript. We thank Virginia Cunningham for help on early analyses for this project. The Green Bank Observatory and the National Radio Astronomy Observatory are facilities of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. (AST 1714688 - NSF; AST1516021 - NSF; NSF)First author draf

Metabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: An investigation at the protein level

The discovery of the IDH1 R132H (IDH1 mut) mutation in low-grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in glioma metabolism. In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA cycle are associated with IDH1 mut. Here, we apply proteomics to FFPE samples of diffuse gliomas with or without IDH1 mutations, to map changes in protein levels associated with this mutation. We observed significant changes in the enz

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo