In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection

Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to possess potent in vitro antipseudomonal activity. Here, they were first shown to preserve the barrier integrity of airway epithelial cells better than the human AMP LL-37. Furthermore, Esc(1-21)-1c was more efficacious than Esc(1-21) and LL-37 in protecting host from pulmonary bacterial infection after a single intra-tracheal instillation at a very low dosage of 0.1 mg/kg. The protection was evidenced by 2-log reduction of lung bacterial burden and was accompanied by less leukocytes recruitment and attenuated inflammatory response. In addition, the diastereomer was more efficient in reducing the systemic dissemination of bacterial cells. Importantly, in contrast to what reported for other AMPs, the peptide was administered at 2 hours after bacterial challenge to better reflect the real life infectious conditions. To the best of our knowledge, this is also the first study investigating the effect of AMPs on airway-epithelia associated genes upon administration to infected lungs. Overall, our data highly support advanced preclinical studies for the development of Esc(1-21)-1c as an efficacious therapeutic alternative against pulmonary P. aeruginosa infection

Stability of Gorenstein flat categories with respect to a semidualizing module

In this paper, we first introduce $\mathcal {W}_F$-Gorenstein modules to establish the following Foxby equivalence: \xymatrix@C=80pt{\mathcal {G}(\mathcal {F})\cap \mathcal {A}_C(R) \ar@[r]^{C\otimes_R-} & \mathcal {G}(\mathcal {W}_F) \ar@[l]^{\textrm{Hom}_R(C,-)}} where $\mathcal {G}(\mathcal {F})$, $\mathcal {A}_C(R)$ and $\mathcal {G}(\mathcal {W}_F)$ denote the class of Gorenstein flat modules, the Auslander class and the class of $\mathcal {W}_F$-Gorenstein modules respectively. Then, we investigate two-degree $\mathcal {W}_F$-Gorenstein modules. An $R$-module $M$ is said to be two-degree $\mathcal {W}_F$-Gorenstein if there exists an exact sequence \mathbb{G}_\bullet=\indent ...\longrightarrow G_1\longrightarrow G_0\longrightarrow G^0\longrightarrow G^1\longrightarrow... in $\mathcal {G}(\mathcal {W}_F)$ such that $M \cong$ \im(G_0\rightarrow G^0) and that $\mathbb{G}_\bullet$ is Hom$_R(\mathcal {G}(\mathcal {W}_F),-)$ and $\mathcal {G}(\mathcal {W}_F)^+\otimes_R-$ exact. We show that two notions of the two-degree $\mathcal {W}_F$-Gorenstein and the $\mathcal {W}_F$-Gorenstein modules coincide when R is a commutative GF-closed ring.Comment: 18 page

Modeling and Analysis of MPTCP Proxy-based LTE-WLAN Path Aggregation

Long Term Evolution (LTE)-Wireless Local Area Network (WLAN) Path Aggregation (LWPA) based on Multi-path Transmission Control Protocol (MPTCP) has been under standardization procedure as a promising and cost-efficient solution to boost Downlink (DL) data rate and handle the rapidly increasing data traffic. This paper aims at providing tractable analysis for the DL performance evaluation of large-scale LWPA networks with the help of tools from stochastic geometry. We consider a simple yet practical model to determine under which conditions a native WLAN Access Point (AP) will work under LWPA mode to help increasing the received data rate. Using stochastic spatial models for the distribution of WLAN APs and LTE Base Stations (BSs), we analyze the density of active LWPA-mode WiFi APs in the considered network model, which further leads to closed-form expressions on the DL data rate and area spectral efficiency (ASE) improvement. Our numerical results illustrate the impact of different network parameters on the performance of LWPA networks, which can be useful for further performance optimization.Comment: IEEE GLOBECOM 201