1,561 research outputs found

    Measuring situation awareness in complex systems: Comparison of measures study

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    Situation Awareness (SA) is a distinct critical commodity for teams working in complex industrial systems and its measurement is a key provision in system, procedural and training design efforts. This article describes a study that was undertaken in order to compare three different SA measures (a freeze probe recall approach, a post trial subjective rating approach and a critical incident interview technique) when used to assess participant SA during a military planning task. The results indicate that only the freeze probe recall method produced a statistically significant correlation with performance on the planning task and also that there was no significant correlation between the three methods, which suggests that they were effectively measuring different things during the trials. In conclusion, the findings, whilst raising doubts over the validity of post trial subjective rating and interview-based approaches, offer validation evidence for the use of freeze probe recall approaches to measure SA. The findings are subsequently discussed with regard to their implications for the future measurement of SA in complex collaborative systems

    Phylogeography of Japanese encephalitis virus:genotype is associated with climate

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    The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important etiologic agent of epidemic encephalitis worldwide, and is primarily maintained between vertebrate reservoir hosts (avian and swine) and culicine mosquitoes. There are five genotypes of JEV: GI-V. In recent years, GI has displaced GIII as the dominant JEV genotype and GV has re-emerged after almost 60 years of undetected virus circulation. JEV is found throughout most of Asia, extending from maritime Siberia in the north to Australia in the south, and as far as Pakistan to the west and Saipan to the east. Transmission of JEV in temperate zones is epidemic with the majority of cases occurring in summer months, while transmission in tropical zones is endemic and occurs year-round at lower rates. To test the hypothesis that viruses circulating in these two geographical zones are genetically distinct, we applied Bayesian phylogeographic, categorical data analysis and phylogeny-trait association test techniques to the largest JEV dataset compiled to date, representing the envelope (E) gene of 487 isolates collected from 12 countries over 75 years. We demonstrated that GIII and the recently emerged GI-b are temperate genotypes likely maintained year-round in northern latitudes, while GI-a and GII are tropical genotypes likely maintained primarily through mosquito-avian and mosquito-swine transmission cycles. This study represents a new paradigm directly linking viral molecular evolution and climate

    Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

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    Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that engages innate immune signaling in these cells. Stimulated 3 prime antisense retroviral coding sequences (SPARCS) are oriented inversely in 3' untranslated regions of specific genes enriched for regulation by STAT1 and EZH2. Derepression of these loci results in double-stranded RNA generation following IFN-γ exposure due to bi-directional transcription from the STAT1-activated gene promoter and the 5' long terminal repeat of the antisense ERV. Engagement of MAVS and STING activates downstream TBK1, IRF3, and STAT1 signaling, sustaining a positive feedback loop. SPARCS induction in human tumors is tightly associated with major histocompatibility complex class 1 expression, mesenchymal markers, and downregulation of chromatin modifying enzymes, including EZH2. Analysis of cell lines with high inducible SPARCS expression reveals strong association with an AXL/MET-positive mesenchymal cell state. While SPARCS-high tumors are immune infiltrated, they also exhibit multiple features of an immune-suppressed microenviroment. Together, these data unveil a subclass of ERVs whose derepression triggers pathologic innate immune signaling in cancer, with important implications for cancer immunotherapy

    The Cosmology of Composite Inelastic Dark Matter

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    Composite dark matter is a natural setting for implementing inelastic dark matter - the O(100 keV) mass splitting arises from spin-spin interactions of constituent fermions. In models where the constituents are charged under an axial U(1) gauge symmetry that also couples to the Standard Model quarks, dark matter scatters inelastically off Standard Model nuclei and can explain the DAMA/LIBRA annual modulation signal. This article describes the early Universe cosmology of a minimal implementation of a composite inelastic dark matter model where the dark matter is a meson composed of a light and a heavy quark. The synthesis of the constituent quarks into dark mesons and baryons results in several qualitatively different configurations of the resulting dark matter hadrons depending on the relative mass scales in the system.Comment: 31 pages, 4 figures; references added, typos correcte

    Mechanisms driving variability in the ocean forcing of Pine Island Glacier

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    Pine Island Glacier (PIG) terminates in a rapidly melting ice shelf, and ocean circulation and temperature are implicated in the retreat and growing contribution to sea level rise of PIG and nearby glaciers. However, the variability of the ocean forcing of PIG has been poorly constrained due to a lack of multi-year observations. Here we show, using a unique record close to the Pine Island Ice Shelf (PIIS), that there is considerable oceanic variability at seasonal and interannual timescales, including a pronounced cold period from October 2011 to May 2013. This variability can be largely explained by two processes: cumulative ocean surface heat fluxes and sea ice formation close to PIIS; and interannual reversals in ocean currents and associated heat transport within Pine Island Bay, driven by a combination of local and remote forcing. Local atmospheric forcing therefore plays an important role in driving oceanic variability close to PIIS

    A data-driven framework for modelling community energy demand

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    Data driven models that integrate advanced analytics involving statistical and machine learning algorithms are widely applied for simulating and predicting energy demand at the community level. These models are used to inform various energy efficiency measures, infrastructure development, planning and investment decision. The paper presents an innovative framework for simulating and projecting climate change impacts on the future dynamics of community energy demand. The modelling framework selectively couples some of the most advanced analytical approaches and its potential are demonstrated using a case study community “Auroville” located in India

    A Mixed-Methods Approach for Evaluating the Influence of Residential Practices for Thermal Comfort on Electricity Consumption in Auroville, India

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    With rapid global economic growth and a rise in disposable household income, particularly within a progressively warming planet, the escalating demand for energy to achieve thermal comfort has become a salient concern in the Global South, notably in emerging economies like India. This burgeoning need for cooling solutions has not only underscored the vital role of energy consumption but has also accentuated the imperative of comprehending the ensuing implications for electricity policy and strategic planning, particularly within the ambit of the Global South. This study explored the nuanced landscape of active cooling within an intentional community, Auroville, in southern India, aiming to discern the factors underpinning household preferences and practices in the pursuit of thermal comfort. Employing a mixed-methods approach, this study contributed empirically and methodologically to the interdisciplinary discourse by analysing residential electricity consumption patterns and cooling practices within selected households in the specified community. The study unfolded in three methodological stages: firstly, an analysis of climatic data coupled with an environmental stress index (ESI) assessment; secondly, the monitoring of end-user electricity consumption followed by rigorous data analysis; and lastly, the utilisation of qualitative in-depth interviews and observational techniques. This study’s outcome yielded empirical insights into the unprecedented shifts in the ESI for Auroville since 2014. Furthermore, the study unravelled the intricate complexities inherent in occupant behaviour within residential structures, thereby offering valuable insights into the practices that shape householders’ cooling preferences. This research enriched the understanding of the dynamics of energy consumption in the pursuit of thermal comfort and contributes to the broader discourse on sustainable development and energy policy in the context of climate change

    Exclusive ρ0\rho^0 electroproduction on the proton at CLAS

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    The epepρ0e p\to e^\prime p \rho^0 reaction has been measured, using the 5.754 GeV electron beam of Jefferson Lab and the CLAS detector. This represents the largest ever set of data for this reaction in the valence region. Integrated and differential cross sections are presented. The WW, Q2Q^2 and tt dependences of the cross section are compared to theoretical calculations based on tt-channel meson-exchange Regge theory on the one hand and on quark handbag diagrams related to Generalized Parton Distributions (GPDs) on the other hand. The Regge approach can describe at the \approx 30% level most of the features of the present data while the two GPD calculations that are presented in this article which succesfully reproduce the high energy data strongly underestimate the present data. The question is then raised whether this discrepancy originates from an incomplete or inexact way of modelling the GPDs or the associated hard scattering amplitude or whether the GPD formalism is simply inapplicable in this region due to higher-twists contributions, incalculable at present.Comment: 29 pages, 29 figure

    Remote work might unlock solar PV\u27s potential of cracking the \u27Duck Curve\u27

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    Integrating renewable energy technologies into a decentralised smart grid presents the ‘Duck Curve’ challenge — the disparity between peak demand and solar photovoltaic (PV) yield. Smart grid operators still lack an effective solution to this problem, resulting in the need to maintain standby fossil fuel-fired plants. The COVID-19 pandemic-induced lockdowns necessitated a shift to remote work (work-from-home) and home-based education. The primary objective of this study was to explore mitigating strategies for the duck curve challenge by investigating this notable shift in behaviour by examining the effect of remote work and education on grid and decentralised solar PV electricity use in 100 households with battery energy storage in the southwest of the UK. This study examined 1-min granular grid electricity and decentralised solar energy consumption data for April–August 2019 and 2020. The findings revealed statistically significant disparities in energy demand. Notably, there was a 1.4—10% decrease in average electricity consumption from April to August 2020 (during and following the lockdown) compared to the corresponding months of 2019. Furthermore, household grid electricity consumption was reduced by 24—25%, while self-consumption from solar PV systems increased by 7—8% during the lockdown in April and May 2020 compared to 2019. This increase in self-consumption was particularly prominent in the morning and afternoon, possibly attributed to the growing prevalence of work-from-home and home-based education. The dynamic shifts in energy consumption patterns emphasised the role of decentralised solar PV energy in meeting the evolving needs of households during unprecedented societal changes. Additionally, remote work might unlock decentralised solar PV\u27s potential in resolving the ‘Duck Curve’, urging further investigation into the implications for energy infrastructure and policy development
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