The role of epigenetics in renal ageing

An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of age-related organ dysfunction. Mechanistic insight into how epigenetic factors regulate ageing throughout the life course, linked to a decline in renal function with ageing, is already proving to be of value in the analyses of clinical and epidemiological cohorts. Noncoding RNAs provide epigenetic regulatory circuits within the kidney, which reciprocally interact with DNA methylation processes, histone modification and chromatin. These interactions have been demonstrated to reflect the biological age and function of renal allografts. Epigenetic factors control gene expression and activity in response to environmental perturbations. They also have roles in highly conserved signalling pathways that modulate ageing, including the mTOR and insulin/insulin-like growth factor signalling pathways, and regulation of sirtuin activity. Nutrition, the gut microbiota, inflammation and environmental factors, including psychosocial and lifestyle stresses, provide potential mechanistic links between the epigenetic landscape of ageing and renal dysfunction. Approaches to modify the renal epigenome via nutritional intervention, targeting the methylome or targeting chromatin seem eminently feasible, although caution is merited owing to the potential for intergenerational and transgenerational effects

Counseling and Educational Strategies to Promote Student Success for Students Living in Poverty

This session will provide school counselors and teachers with educational and counseling strategies for working with students living in poverty. The strategies provided will be specific to each school level (elementary, middle, and high) as well as to the areas of educational support, advocacy, and engagement

Counseling and Educational Strategies for School Counselors Working with Students\u27 Living in Poverty

This session focuses on educational and counseling strategies for School Counselors working in high poverty communities. This includes an emphasis on counseling strategies to promote educational outcomes, advocacy, and addressing the needs of students living in poverty. Specific interventions, resources and strategies will be provided. These interventions will include consideration of elementary, middle and high school students

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell line