New records of alien polychaete species for the coasts of Turkey

This paper reports two alien polychaete species (Phyllodoce longifrons and Exogone africana) new to the faunal inventory of Turkey as well as two species (Ceratonereis mirabilis and Onuphis eremita oculata) new to the entire Aegean Sea. It is the first time the phyllodocid species P. longifrons is being classified as an alien species. The re-descriptions of P. longifrons and E. africana are given, and their alien status and establishment success are discussed

Reproductive biology of Diopatra neapolitana (Annelida, Onuphidae), an exploited natural resource in Ria de Aveiro (Northwestern Portugal)

Diopatra neapolitana Delle Chiaje, 1841 (Annelida, Onuphidae) is an important economic natural resource in Ria de Aveiro (northwestern coast of Portugal) and throughout Europe. The species is intensively harvested for use as fresh bait. However, there is only limited knowledge about its life cycle derived from a previous study in Mediterranean Sea. Reproduction and development patterns are known to vary biogeographically, making it important to base management decisions on locally appropriate information. This work examines reproduction patterns for populations from the Eastern Atlantic, which have not previously been assessed, with an eye towards drawing Atlantic–Mediterranean comparisons and informing local management strategies. The study was conducted from May 2007 to April 2009 in Ria de Aveiro. The reproductive biology of D. neapolitana was described from the proportional variation of worms with gametes in the coelom and from the progression of the oocyte diameter. Individuals with gametes inside the coelom were found all year round, but the peak reproductive period occurred between May and August, when almost all individuals had gametes in the coelom and females contained more oocytes than at any other time of the year. The overall male:female ratio was close to 1:1 and the oocyte diameter ranged from 40 to 240 μm. In vitro fertilization was performed and the results compared to other studies. Based on the present results, some protection measures are suggested to implement a sustainable exploitation of the species

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes

Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host inflammatory response. Methods: PPARα, β and γ mRNA levels were measured in peripheral blood cells of CF patients and healthy subjects via RT-PCR. PPARα protein expression and subcellular localization was determined via western blot and immunofluorescence, respectively. The activity of PPARα was analyzed by gel shift assay. Results: In lymphocytes, the expression of PPARα mRNA, but not of PPARβ, was reduced (-37%; p < 0.002) in CF patients compared with healthy persons and was therefore further analyzed. A similar reduction of PPARα was observed at protein level (-26%; p < 0.05). The transcription factor was mainly expressed in the cytosol of lymphocytes, with low expression in the nucleus. Moreover, DNA binding activity of the transcription factor was 36% less in lymphocytes of patients (p < 0.01). For PPARα and PPARβ mRNA expression in monocytes and neutrophils, no significant differences were observed between CF patients and healthy persons. In all cells, PPARγ mRNA levels were below the detection limit. Conclusion: Lymphocytes are important regulators of the inflammatory response by releasing cytokines and antibodies. The diminished lymphocytic expression and activity of PPARα may therefore contribute to the inflammatory processes that are observed in CF

Application of Distributed Knowledge Bases in Intelligent Manufacturing

The authors consider independent knowledge bases operating on separate work stations networked together within the domain of knowledge-based scheduling. The scheduling problem is addressed through distributed knowledge bases that have an ability to pass information back and forth between small knowledge bases functioning at different decision-making levels. A small manufacturing plant is conceptualized in order to experiment with this process. The general outline and areas of the manufacturing shop are shown. The domain specific area for the knowledge bases is to optimize the scheduling of work at each work station in order to meet a weekly quota. Automatic guided vehicle, circuit board assembly, and mill and lathe work cells are discussed

First record of Paraprionospio coora Wilson, 1990 (Polychaeta: Spionidae) from the Mediterranean Sea)

The spionid polychaete Paraprionospio pinnata (Ehlers, 1901) has been widely reported from the Mediterranean Sea. We examined some specimens belonging to the genera Paraprionospio that had been collected from the Aegean Sea, Sea of Marmara and the Spanish Mediterranean coast, and identified them as Paraprionospio coora Wilson, 1990, which is new to the Mediterranean fauna. This finding indicates that P. coora has a widespread geographical distribution in Australia, Far East and the Mediterranean, and suggests that the previous records of P. pinnata from the Mediterranean are questionable

Cost Justification of an Expert System

It is pointed out that, like other projects which spend corporate dollars, an expert system must be analyzed for its economic and strategic worth to the organization. Both traditional engineering economy project analysis and multivariate holistic methods can be applicable. The fundamental strategy of the analyst is to decide upon the evaluation methodologies, gather cost and benefit data, study the project from various perspectives, and present the results and recommendations

An Empirical Analysis of Backpropagation Error Surface Initiation for Injection Molding Process Control

Backpropagation neural networks are trained by adjusting initially random interconnecting weights according to the steepest local error surface gradient. The authors examine the practical implications of the arbitrary starting point on the error landscape of the ensuing trained network. The effects on network convergence and performance are tested empirically, varying parameters such as network size, training rate, transfer function and data representation. The data used are live process control data from an injection molding plan

New records of alien polychaete species for the coasts of Turkey

This paper reports two alien polychaete species (Phyllodoce longifrons and Exogone africana) new to the faunal inventory of Turkey as well as two species (Ceratonereis mirabilis and Onuphis eremita oculata) new to the entire Aegean Sea. It is the first time the phyllodocid species P. longifrons is being classified as an alien species. The re-descriptions of P. longifrons and E. africana are given, and their alien status and establishment success are discussed

Oral health and related factors in a group of children with cystic fibrosis in Istanbul, Turkey

Background: Cystic fibrosis (CF) patients can be considered as high caries risk patients because they frequently consume sugar.rich food between meals and they have a high intake of sugar containing syrups, aerosols, and salivary flow reducing medication. Variable caries prevalences were reported in CF patients in previous studies. There are no studies related to CF and salivary thromboplastic activity, which can be presented as a marker of wound healing and bleeding tendency of oral cavity.Objective: The aim of this study was to compare oral health status and salivary pH, flow rate, and thromboplastic activity in children with CF and healthy controls.Materials and Methods: Asample of 35 children with CF (23 girls and 12 boys), and 12 healthy control subjects (6 girls and 6 boys) were selected. Caries experience, oral hygiene, and dental erosion were assessed. Salivary flow rate, pH, thromboplastic activity, and total protein content were determined. Differences between the groups were evaluated using Chi.square test with a significance level set at 0.05.Results: The differences between children with CF and healthy controls in tooth brushing frequency, use of fluoride tablets, caries experience, dental erosion index, oral hygiene index, salivary flow rate and total protein levels were not statistically significant (P &gt; 0.05). Salivary thromboplastic activity of the CF group was significantly lower than the healthy controls (P &lt; 0.01).Conclusion: Large population studies may be necessary to establish the role of salivary thromboplastic activity in children with CF considering our findings related to the decreased salivary thromboplastic activity, which  may indicate delayed oral wound healing process.Key words: Caries, children, cystic fibrosis, saliva, salivary thromboplastic activit

Prescribing indicators at primary health care centers within the WHO African region: a systematic analysis (1995-2015)

Abstract Background Rational medicine use is essential to optimize quality of healthcare delivery and resource utilization. We aim to conduct a systematic review of changes in prescribing patterns in the WHO African region and comparison with WHO indicators in two time periods 1995–2005 and 2006–2015. Methods Systematic searches were conducted in PubMed, Scopus, Web of science, Africa-Wide Nipad, Africa Journals Online (AJOL), Google scholar and International Network for Rational Use of Drugs (INRUD) Bibliography databases to identify primary studies reporting prescribing indicators at primary healthcare centres (PHCs) in Africa. This was supplemented by a manual search of retrieved references. We assessed the quality of studies using a 14-point scoring system modified from the Downs and Black checklist with inclusions of recommendations in the WHO guidelines. Results Forty-three studies conducted in 11 African countries were included in the overall analysis. These studies presented prescribing indicators based on a total 141,323 patient encounters across 572 primary care facilities. The results of prescribing indicators were determined as follows; average number of medicines prescribed per patient encounter = 3.1 (IQR 2.3–4.8), percentage of medicines prescribed by generic name =68.0 % (IQR 55.4–80.3), Percentage of encounters with antibiotic prescribed =46.8 % (IQR 33.7–62.8), percentage of encounters with injection prescribed =25.0 % (IQR 18.7–39.5) and the percentage of medicines prescribed from essential medicines list =88.0 % (IQR 76.3–94.1). Prescribing indicators were generally worse in private compared with public facilities. Analysis of prescribing across two time points 1995–2005 and 2006–2015 showed no consistent trends. Conclusions Prescribing indicators for the African region deviate significantly from the WHO reference targets. Increased collaborative efforts are urgently needed to improve medicine prescribing practices in Africa with the aim of enhancing the optimal utilization of scarce resources and averting negative health consequences