Media representations of the nouveaux riches and the cultural constitution of the global middle class

The article offers a distinctive account of how the nouveaux riches serve as an anchor for a range of upper- middle- class ambivalences and anxieties associated with transformations of capitalism and shifting global hierarchies. Reflecting the long- term association of middle- class symbolic boundaries with notions of refinement and respectability, it examines how the discourse of civility shapes how the nouveaux riches are represented to the upper middle class, identifying a number of recurrent media frames and narrative tropes related to vulgarity, civility, and order. The author argues that these representations play a central role in the reproduction of the Western professional middle class, and in the cultural constitution of a global middle class — professional, affluent, urban, and affiliated by an aesthetic regime of civility that transcends national borders. The findings underline the significance of representations of the new super- rich as devices through which the media accomplish the global circulation of an upper- middle- class repertoire of cultural capital, which is used both to police shifting class boundaries and to establish a legitimate preserve for univorous snobbishness

The design with intent method: A design tool for influencing user behaviour

The official published version can be found at the link below.Using product and system design to influence user behaviour offers potential for improving performance and reducing user error, yet little guidance is available at the concept generation stage for design teams briefed with influencing user behaviour. This article presents the Design with Intent Method, an innovation tool for designers working in this area, illustrated via application to an everyday human–technology interaction problem: reducing the likelihood of a customer leaving his or her card in an automatic teller machine. The example application results in a range of feasible design concepts which are comparable to existing developments in ATM design, demonstrating that the method has potential for development and application as part of a user-centred design process

Café nation? Exploring the growth of the UK café industry

The UK café industry has experienced significant growth over the last decade. With over 18 800 outlets, and a turnover of £7.2 billion recorded in 2014, the industry represents an important component of the retail sector. Industry commentators forecast that the industry will continue to grow and that there will be 27 000 outlets by 2020. This article provides an overview of the UK café industry and highlights the key drivers of it's rapid growth. It explores the ways that a new economic geography is quietly made as the café industry refashions our high streets. The article culminates by presenting an illustrative typology of café types which comprise the café industry in the UK, highlighting the need for greater research into the landscape of the café industry as it develops, and the roles that café spaces play in different communities.Publisher Statement: This is the peer reviewed version of the following article: Ferreira, J 2016, 'Café nation? Exploring the growth of the UK café industry' Area, vol 49, no. 1, pp. 69-76, which has been published in final form at https://dx.doi.org/10.1111/area.12285 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.<br/

Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.

Adenylate kinases (AKs) are phosphotransferases that regulate the cellular adenine nucleotide composition and play a critical role in the energy homeostasis of all tissues. The AK2 isoenzyme is expressed in the mitochondrial intermembrane space and is mutated in reticular dysgenesis (RD), a rare form of severe combined immunodeficiency (SCID) in humans. RD is characterized by a maturation arrest in the myeloid and lymphoid lineages, leading to early onset, recurrent, and overwhelming infections. To gain insight into the pathophysiology of RD, we studied the effects of AK2 deficiency using the zebrafish model and induced pluripotent stem cells (iPSCs) derived from fibroblasts of an RD patient. In zebrafish, Ak2 deficiency affected hematopoietic stem and progenitor cell (HSPC) development with increased oxidative stress and apoptosis. AK2-deficient iPSCs recapitulated the characteristic myeloid maturation arrest at the promyelocyte stage and demonstrated an increased AMP/ADP ratio, indicative of an energy-depleted adenine nucleotide profile. Antioxidant treatment rescued the hematopoietic phenotypes in vivo in ak2 mutant zebrafish and restored differentiation of AK2-deficient iPSCs into mature granulocytes. Our results link hematopoietic cell fate in AK2 deficiency to cellular energy depletion and increased oxidative stress. This points to the potential use of antioxidants as a supportive therapeutic modality for patients with RD

The English City Riots of 2011, "Broken Britain" and the retreat into the present

The responses to the English city riots of 2011 bear a remarkable resemblance to those of historical urban disorders in terms of the way in which they are framed by concerns over "moral decline", "social malaise" and a "lack of self-restraint" among certain sections of the population. In this paper we draw on the work of Norbert Elias and take a long-term perspective in exploring historical precedents and parallels relating to urban disorder and anti-social behaviour. We reject the notion of "Broken Britain" and argue that a more "detached" perspective is necessary in order to appreciate that perceived crises of civilisation are ubiquitous to the urban condition. Through this historical analysis, framed by Elias' theory of involvement and detachment, we present three key arguments. Firstly, that a 'retreat into the present' is evident among both policy discourse and social science in responding to contemporary urban disorder, giving rise to ahistorical accounts and the romanticisation of previous eras; secondly, that particular moral panics have always arisen, specifically focused upon young and working class populations and urban disorder; and, thirdly, that previous techniques of governance to control these populations were often far more similar to contemporary mechanisms than many commentaries suggest. We conclude by advocating a long-term, detached perspective in discerning historical precedents and their direct linkages to the present; and in identifying what is particular about today's concerns and responses relating to urban disorder

Citizens and Condemnation: Strategic Uses of International Human Rights Pressure in Authoritarian States

Governments with strict control over the information that their citizens hear from foreign sources are regular targets of human rights pressure, but we know little about how this information matters in the domestic realm. I argue that authoritarian regimes strategically pass on certain types of external pressure to their public to “internationalize” human rights violations, making citizens view human rights in terms of defending their nation internationally rather than in terms of individual violations, and making them more likely to be satisfied with their government’s behavior. I find strong support for this model through statistical analysis of Chinese state media reports of external human rights pressure and a survey experiment on Chinese citizens’ responses to pressure on women’s rights. This analysis demonstrates that authoritarian regimes may be able to manipulate international human rights diplomacy to help them retain the support of their population while suppressing their human rights

Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4 butanediol (1,4-BD; BDO) : a literature review with a focus on UK fatalities related to non-medical use

Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased greatly since the early 1990s, being implicated in a rising number of deaths. This paper reviews knowledge on GHB and derivatives, and explores the largest series of deaths associated with their non-medical use. Descriptive analyses of cases associated with GHB/GBL and 1,4 butanediol (1,4-BD) use extracted from the UK’s National Programme on Substance Abuse Deaths database. From 1995 to September 2013, 159 GHB/GBL-associated fatalities were reported. Typical victims: White (92%), young (mean age 32 years); male (82%); with a drug misuse history (70%). Most deaths (79%) were accidental or related to drug use, the remainder (potential) suicides. GHB/GBL alone was implicated in 37%; alcohol 14%; other drugs 28%; other drugs and alcohol 15%. Its endogenous nature and rapid elimination limit toxicological detection. Post-mortem blood levels: mean 482 (range 0 - 6500; S.D. 758) mg/L. Results suggest significant caution is needed when ingesting GHB/GBL, particularly with alcohol, benzodiazepines, opiates, stimulants, and ketamine. More awareness is needed about risks associated with consumption.Peer reviewe

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

Intracellular malaria parasites require lipids for growth and replication. They possess a prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid organelle and is assumed to be necessary for pathogenic blood stage replication. However, the importance of FAS II throughout the complex parasite life cycle remains unknown. We show in a rodent malaria model that FAS II enzymes localize to the sporozoite and liver stage apicoplast. Targeted deletion of FabB/F, a critical enzyme in fatty acid synthesis, did not affect parasite blood stage replication, mosquito stage development and initial infection in the liver. This was confirmed by knockout of FabZ, another critical FAS II enzyme. However, FAS II-deficient Plasmodium yoelii liver stages failed to form exo-erythrocytic merozoites, the invasive stage that first initiates blood stage infection. Furthermore, deletion of FabI in the human malaria parasite Plasmodium falciparum did not show a reduction in asexual blood stage replication in vitro. Malaria parasites therefore depend on the intrinsic FAS II pathway only at one specific life cycle transition point, from liver to blood

Early Results of Combined and Staged Coronary Bypass and Carotid Endarterectomy in Advanced Age Patients in Single Centre

Aim: In present study, we aimed to compare the staged and combined surgery in patients with severe carotid stenosis and coronary atherosclerosis and detect the factors affecting mortality and morbidity. Material and method: Between 2004 and 2008, 120 patients with predominant ischemic heart disease were enrolled to study. Patients were divided into three groups on basis surgery procedure. Group 1 (n=40) includeed patients had coronary artery disease without carotid disease underwent coronary artery by-pass graft (CABG) operation. Group 2 (n=40): included patients underwent combined surgery procedure including CABG and carotid endarterectomy (CEA). Patients underwent staged CABG and CEA were enrolled to Group 3 (n=40). All patients were in advanced aged and were had the same risk factors atributable atherosclerosis Results: Mean age of the patients in all groups were 68 +/- 6, 69 +/- 3, 71 +/- 2 respectively, and 83% were male. Eight patients died in all groups at follow-up(seven in group 2 and 3, and one in group 1) and the difference between both groups was statistically significant (p<0.001). The follow-up period in the intensive care unit, and hospitalization period were not statistically different between CABG group and combined CEA plus CABG group. Conclusion: We think that the results of staged or combined CABG plus CEA surgery are satisfactory in patients with severe carotid disease and advanced coronary artery disease. However, the mortality and morbidity in both procedures are higher than those of alone