PREPARATION AND CHARACTERIZATION OF ENTERIC COATED MUCOADHESIVE TABLET OF CAPTOPRIL

Delayed sustained release formulation is to retard release of the drug form the stomach and release in the intestinal pH. Captopril is recommended as first choice of drug. Attacks of the myocardial infarction are generally in the early morning or night. Captopril is showing less bioavailability in presence of food. With enteric coating problem should be solved out. It also minimizes the gastric irritation of the captopril. Captopril is widely used for the arterial hypertension. It also used for myocardial infarction and in diabetic nephropathy. The drug dose is taken three times daily, which may give poor patients compliance. In the present investigation, an attempt was made to decrease dosing frequency by prepare a mucoadhesive tablets using various polymers such as HPMC K4M, bael gum and chitosan. Eudragit RL100 used as enteric coating polymer. Formulations friability, drug content, surface pH, wash off test, mucoadhesive strength and dissolution study. The results of friability tests carried out for all the formulations are within the official limit and acceptable. According to wash off test the formulation containing bael gum showing better results. All the formulation was showing better swelling property. F4 (formulation containing bael gum) was showing best mucoadhesive strength among all the formulations.  In in-vitro drug release study formulation (F4) containing bael gum showing better control release among all the formulations i.e. 86.488 % in 12 hrs

Value and servitization; Creating complex deployed responsive services

This paper presents a value framework which captures how manufacturing engineering firms are transforming from product to complex service provision where the service is delivered within the customer’s dynamic environment and their ability to capture worth is determined by the success of their customer.Key points:1.A value framework presents the business models for service transformation which requires managers to consider and capture their value proposition, value realisation and worth capture processes2.A characterisation of a particular form of service, named complex deployed responsive services [CDRS]3.CDRS are delivered in partnership with customers, realised off-site and in the customer’s environment and must be responsive to their demands such that their success determines the success of the provider.4.Application of the value framework to a number of business-to-business CDRS has demonstrated its utility in identification and understanding of opportunities for worth capture5.The proposed framework helps firms consider how to avoid value slippage, which is the process where the value creator is unable to capture the worth from their effort