Technical and institutional priorities for enhancing rail/aviation cooperation for the future intercity passenger transportation

Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2005.Includes bibliographical references (leaves 67-68).There are currently about 120 airport rail links existing or proposed to be constructed around the world. The growth in the number of airport rail links reflects the almost relentless growth in air travel and the associated worsening congestion and delays on both landside and airside of airports. Rail-Air Passenger Intermodal Development (RAPID) in the United States has lagged behind the world trend, especially in comparison with Europe and Japan. This paper consists of two tasks: to examine technical priorities for the competitiveness of rail a s a feeder to a irports, a nd to i dentify key b arriers a nd recommend changes for RAPID development in this nation. Having an effective intermodal connection has proved to be the prerequisite for the successfulness of RAPID. When such a connection is available, enhancing intermodal cooperation is likely to be more effective than operating high speed rail in terms of the competitiveness of railfor airport trips. The speed of trains only needs to be high enough to ensure door-to-door trip time advantages over highways and flights in short- to mid- distance corridors. All the necessary technical options for RAPID have been widely applied in the world for decades. Even without technical challenges, RAPID development might be expensive and complicated with with many stakeholders and interest groups directly and indirectly impacted. Lack of effective intermodal infrastructure has been the primary hurdle impeding RAPID development in this nation. Unbalanced development in this nation's intercity passenger transportation system has resulted in the inability of intercity railroads to promote RAPID and the unwillingness of air carriers to connect and cooperate with the rail system.(cont.) These problems make RAPID unlikely to be developed by relying solely on the private sector. Mode separation in the administrative framework and modal bias in policy generate further hurdles for RAPID from the public sector in terms of public funding, information, planning and cooperation. To succesfully achieve RAPID, the federal government must play a major role in terms of provding a) sufficient federal funding specifically for RAPID infrastructures and b) incentives to enhance the willingness of state and localities to support RAPID. The federal leadership and institutional support will also be necessary to increase modal integration to facilitate RAPID research, planning and decision making.by Dalong Shi.S.M

Low-Stroke Actuation for a Serial Robot

A serial robot includes a base, first and second segments, a proximal joint joining the base to the first segment, and a distal joint. The distal joint that joins the segments is serially arranged and distal with respect to the proximal joint. The robot includes first and second actuators. A first tendon extends from the first actuator to the proximal joint and is selectively moveable via the first actuator. A second tendon extends from the second actuator to the distal joint and is selectively moveable via the second actuator. The robot includes a transmission having at least one gear element which assists rotation of the distal joint when an input force is applied to the proximal and/or distal joints by the first and/or second actuators. A robotic hand having the above robot is also disclosed, as is a robotic system having a torso, arm, and the above-described hand

Single-shot compressed ultrafast photography: a review

Compressed ultrafast photography (CUP) is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames. This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot. With recent unprecedented technical developments and extensions of this methodology, it has been widely used in ultrafast optical imaging and metrology, ultrafast electron diffraction and microscopy, and information security protection. We review the basic principles of CUP, its recent advances in data acquisition and image reconstruction, its fusions with other modalities, and its unique applications in multiple research fields

Conditional Random Fields as Recurrent Neural Networks

Pixel-level labelling tasks, such as semantic segmentation, play a central role in image understanding. Recent approaches have attempted to harness the capabilities of deep learning techniques for image recognition to tackle pixel-level labelling tasks. One central issue in this methodology is the limited capacity of deep learning techniques to delineate visual objects. To solve this problem, we introduce a new form of convolutional neural network that combines the strengths of Convolutional Neural Networks (CNNs) and Conditional Random Fields (CRFs)-based probabilistic graphical modelling. To this end, we formulate mean-field approximate inference for the Conditional Random Fields with Gaussian pairwise potentials as Recurrent Neural Networks. This network, called CRF-RNN, is then plugged in as a part of a CNN to obtain a deep network that has desirable properties of both CNNs and CRFs. Importantly, our system fully integrates CRF modelling with CNNs, making it possible to train the whole deep network end-to-end with the usual back-propagation algorithm, avoiding offline post-processing methods for object delineation. We apply the proposed method to the problem of semantic image segmentation, obtaining top results on the challenging Pascal VOC 2012 segmentation benchmark.Comment: This paper is published in IEEE ICCV 201

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway

Background: Gankyrin has shown to be overexpressed in human liver cancers and plays a complex role in hepatocarcinogenesis. Panobinostat (LBH589), a new hydroxamic acid-derived histone deacetylase inhibitor has shown promising anticancer effects recently. Here, we investigated the potential of LBH589 as a form of treatment for hepatocellular carcinoma (HCC). Methods: Gankyrin plasmid was transfected into HCC cells, and the cells were selected for more than 4 weeks by incubation with G418 for overexpression clones. The therapeutic effects of LBH589 were evaluated in vitro and in vivo. Cell proliferation, apoptosis, cell cycle, invasive potential, and epithelial-mesenchy-mal transition (EMT) were examined. Results: LBH589 significantly inhibited HCC growth and metastasis in vitro and in vivo. Western blotting analysis indicated that LBH589 could decrease the expression of gankyrin and subsequently reduced serine-phosphorylated Akt and tyrosine-phosphorylated STAT3 expression although the total Akt and STAT3 were unaffected. LBH589 inhibited metastasis in vitro via down-regulation of N-cadherin, vimentin, TWIST1, VEGF and up-regulation of E-cadherin. LBH589 also induced apoptosis and G1 phase arrest in HCC cell lines. Ectopic expression of gankyrin attenuated the effects of LBH589, which indicates that gankyrin might play an important role in LBH589 mediated anticancer effects. Lastly, in vivo study indicated that LBH589 inhibited tumor growth and metastasis, without discernable adverse effects comparing to control group, with abrogating gankyrin/STAT3/Akt pathway. Conclusions: Our results suggested that LBH589 could inhibit HCC growth and metastasis through down-regulating gankyrin/STAT3/Akt pathway. LBH589 may present itself as a novel therapeutic strategy for HCC

Entrepreneurial decision-making under risk : prospect theory and dual-process theory.

This research addresses the question of why some people become entrepreneurs whereas others do not. The debate has been going on for decades in entrepreneurship. In this dissertation, I address this question by decomposing it into two related questions. The first question is whether entrepreneurs make different decisions compared to non-entrepreneurs when they are facing the same opportunities under risk. The second question is whether these differences in decision-making (if any) are due to the natural proclivity of entrepreneurs themselves. To identify the differences of entrepreneurial decision-making between entrepreneurs and non-entrepreneurs, this study investigates the nexus between entrepreneurs and opportunities from both aspects simultaneously. From an entrepreneur’s aspect, based on dual-process theory, I examine how different styles of entrepreneurial thinking influence their decision-making. Considering an opportunity itself, based on prospect theory, I test how different types of opportunity framing influence entrepreneurial decision-making. The results indicate that entrepreneurs have lower evaluations than non-entrepreneurs do when they are facing the same opportunities under risk. The opportunities in a loss frame have higher evaluations than those in a gain frame. The evaluations are higher in System 2 thinking than in System 1 thinking. The findings suggest that entrepreneurs do make different decisions than non-entrepreneurs and that these differences are more likely due to the natural proclivities of at least some entrepreneurs. These findings provide new insights for the entrepreneurial decision-making literature and enlighten some promising future research