Zwicky Transient Facility constraints on the optical emission from the nearby repeating FRB 180916.J0158+65

The discovery rate of fast radio bursts (FRBs) is increasing dramatically thanks to new radio facilities. Meanwhile, wide-field instruments such as the 47 deg$^2$ Zwicky Transient Facility (ZTF) survey the optical sky to study transient and variable sources. We present serendipitous ZTF observations of the CHIME repeating source FRB 180916.J0158+65, that was localized to a spiral galaxy 149 Mpc away and is the first FRB suggesting periodic modulation in its activity. While 147 ZTF exposures corresponded to expected high-activity periods of this FRB, no single ZTF exposure was at the same time as a CHIME detection. No $>3\sigma$ optical source was found at the FRB location in 683 ZTF exposures, totalling 5.69 hours of integration time. We combined ZTF upper limits and expected repetitions from FRB 180916.J0158+65 in a statistical framework using a Weibull distribution, agnostic of periodic modulation priors. The analysis yielded a constraint on the ratio between the optical and radio fluences of $\eta \lesssim 200$, corresponding to an optical energy $E_{\rm opt} \lesssim 3 \times 10^{46}$ erg for a fiducial 10 Jy ms FRB (90% confidence). A deeper (but less statistically robust) constraint of $\eta \lesssim 3$ can be placed assuming a rate of $r(>5$ Jy ms)= hr$^{-1}$ and $1.2\pm 1.1$ FRB occurring during exposures taken in high-activity windows. The constraint can be improved with shorter per-image exposures and longer integration time, or observing FRBs at higher Galactic latitudes. This work demonstrated how current surveys can statistically constrain multi-wavelength counterparts to FRBs even without deliberately scheduled simultaneous radio observation.Comment: Accepted for publication in ApJL, 9 pages, 4 figures, 1 tabl

One-year outcomes after transcatheter insertion of an interatrial shunt device for the management of heart failure with preserved ejection fraction

Background—Heart failure with preserved ejection fraction has a complex pathophysiology and remains a therapeutic challenge. Elevated left atrial pressure, particularly during exercise, is a key contributor to morbidity and mortality. Preliminary analyses have demonstrated that a novel interatrial septal shunt device that allows shunting to reduce the left atrial pressure provides clinical and hemodynamic benefit at 6 months. Given the chronicity of heart failure with preserved ejection fraction, evidence of longer-term benefit is required. Methods and Results—Patients (n=64) with left ventricular ejection fraction ≥40%, New York Heart Association class II–IV, elevated pulmonary capillary wedge pressure (≥15 mm Hg at rest or ≥25 mm Hg during supine bicycle exercise) participated in the open-label study of the interatrial septal shunt device. One year after interatrial septal shunt device implantation, there were sustained improvements in New York Heart Association class (P<0.001), quality of life (Minnesota Living with Heart Failure score, P<0.001), and 6-minute walk distance (P<0.01). Echocardiography showed a small, stable reduction in left ventricular end-diastolic volume index (P<0.001), with a concomitant small stable increase in the right ventricular end-diastolic volume index (P<0.001). Invasive hemodynamic studies performed in a subset of patients demonstrated a sustained reduction in the workload corrected exercise pulmonary capillary wedge pressure (P<0.01). Survival at 1 year was 95%, and there was no evidence of device-related complications. Conclusions—These results provide evidence of safety and sustained clinical benefit in heart failure with preserved ejection fraction patients 1 year after interatrial septal shunt device implantation. Randomized, blinded studies are underway to confirm these observations

The Zwicky Transient Facility Observing System

The Zwicky Transient Facility (ZTF) is a synoptic optical survey for high-cadence time-domain astronomy. Building upon the experience and infrastructure of the highly successful Palomar Transient Factory (PTF) team, ZTF will survey more than an order of magnitude faster than PTF in sky area and volume in order to identify rare, rapidly varying optical sources. These sources will include a trove of supernovae, exotic explosive transients, unusual stellar variables, compact binaries, active galactic nuclei, and asteroids. The single-visit depth of 20.4 mag is well matched to spectroscopic follow-up observations, while the co-added images will provide wide sky coverage 1.5 – 2 mag deeper than SDSS. The ZTF survey will cover the entire Northern Sky and revisit fields on timescales of a few hours, providing hundreds of visits per field each year, an unprecedented cadence, as required to detect fast transients and variability. This high-cadence survey is enabled by an observing system based on a new camera having 47 deg^2 field of view – a factor of 6.5 greater than the existing PTF camera - equipped with fast readout electronics, a large, fast exposure shutter, faster telescope and dome drives, and various measures to optimize delivered image quality. Our project has already received an initial procurement of e2v wafer-scale CCDs and we are currently fabricating the camera cryostat. International partners and the NSF committed funds in June 2014 so construction can proceed as planned to commence engineering commissioning in 2016 and begin operations in 2017. Public release will allow broad utilization of these data by the US astronomical community. ZTF will also promote the development of transient and variable science methods in preparation for the seminal first light of LSST

Rewriting Modulo Traced Comonoid Structure

In this paper we adapt previous work on rewriting string diagrams using hypergraphs to the case where the underlying category has a traced comonoid structure, in which wires can be forked and the outputs of a morphism can be connected to its input. Such a structure is particularly interesting because any traced Cartesian (dataflow) category has an underlying traced comonoid structure. We show that certain subclasses of hypergraphs are fully complete for traced comonoid categories: that is to say, every term in such a category has a unique corresponding hypergraph up to isomorphism, and from every hypergraph with the desired properties, a unique term in the category can be retrieved up to the axioms of traced comonoid categories. We also show how the framework of double pushout rewriting (DPO) can be adapted for traced comonoid categories by characterising the valid pushout complements for rewriting in our setting. We conclude by presenting a case study in the form of recent work on an equational theory for sequential circuits: circuits built from primitive logic gates with delay and feedback. The graph rewriting framework allows for the definition of an operational semantics for sequential circuits

The Zwicky Transient Facility Camera

The Zwicky Transient Facility Camera (ZTFC) is a key element of the ZTF Observing System, the integrated system of optoelectromechanical instrumentation tasked to acquire the wide-field, high-cadence time-domain astronomical data at the heart of the Zwicky Transient Facility. The ZTFC consists of a compact cryostat with large vacuum window protecting a mosaic of 16 large, wafer-scale science CCDs and 4 smaller guide/focus CCDs, a sophisticated vacuum interface board which carries data as electrical signals out of the cryostat, an electromechanical window frame for securing externally inserted optical filter selections, and associated cryo-thermal/vacuum system support elements. The ZTFC provides an instantaneous 47 deg^2 field of view, limited by primary mirror vignetting in its Schmidt telescope prime focus configuration. We report here on the design and performance of the ZTF CCD camera cryostat and report results from extensive Joule-Thompson cryocooler tests that may be of broad interest to the instrumentation community

A compositional theory of digital circuits

A theory is compositional if complex components can be constructed out of simpler ones on the basis of their interfaces, without inspecting their internals. Digital circuits, despite being studied for nearly a century and used at scale for about half that time, have until recently evaded a fully compositional theoretical understanding. The sticking point has been the need to avoid feedback loops that bypass memory elements, the so called 'combinational feedback' problem. This requires examining the internal structure of a circuit, defeating compositionality. Recent work remedied this theoretical shortcoming by showing how digital circuits can be presented compositionally as morphisms in a freely generated Cartesian traced (or dataflow) category. The focus was to support a better syntactical understanding of digital circuits, culminating in the formulation of novel operational semantics for digital circuits. In this paper we shift the focus onto the denotational theory of such circuits, interpreting them as functions on streams with to certain properties. These ensure that the model is fully abstract, i.e. the equational theory and the semantic model are in perfect agreement. To support this result we introduce two key equations: the first can reduce circuits with combinational feedback to circuits without combinational feedback via finite unfoldings of the loop, and the second can translate between open circuits with the same behaviour syntactically by reducing the problem to checking a finite number of closed circuits. The most important consequence of this new semantics is that we can now give a recipe that ensures a circuit always produces observable output, thus using the denotational model to inform and improve the operational semantics.Comment: Restructured and refined presentation, 21 page

Factors that predict fertility desires for people living with HIV infection at a support and treatment centre in Kabale, Uganda

<p>Abstract</p> <p>Background</p> <p>Studies from different contexts worldwide indicate that HIV positive patients manifest high-risk sexual behavior characterized by fertility intentions, multiple sexual partners, non-use of contraceptives and non-disclosure of HIV status to their sex partners. The objective was to analyze fertility desires among persons living with HIV at a treatment centre in Kabale Hospital, Southwestern Uganda.</p> <p>Methods</p> <p>From January to August 2009, we interviewed 400 HIV positive patients seeking care using an interviewer-administered questionnaire. We assessed socio-demographic variables, reproductive history, sexuality and fertility desires. At bivariate and multivariate analysis, characteristics of participants who reported or did not report desire to have a child in the near future were compared.</p> <p>Results</p> <p>Of the 400 respondents, (25.3%) were male, 47.3% were aged 25-34 years, over 85% were currently married or had ever been married, and the 62% had primary level of education or less. Over 17% had produced a child since the HIV diagnosis was made, and 28.6% reported that they would like to have a child in the near future. Age of the respondent, being single (versus being ever-married) and whether any of the respondents' children had died were inversely associated with fertility intentions.</p> <p>Conclusion</p> <p>Factors inversely associated with fertility intentions were age of the respondent, marital status and whether any of the respondents' children had died. Use of antiretroviral therapy was not associated with fertility intentions.</p

Alien Physicians and Their Admission into the United States

This Article discusses legislation passed by Congress in 1976 to drastically reduce the eligibility of alien physicians to enter the United States because of a fear of inferior medical services and a belief that such immigration was leading to a shortage of health care providers in some foreign nations. The article surveys the new requirements such as passing both medical and English competence examinations as well as obtaining individual labor certifications. The article goes on to discuss ways in which alien physicians can come to the Unites States without passing these examinations

Landscape-Scale Dynamics of Aspen in Rocky Mountain National Park, Colorado

Past studies of quaking aspen in Rocky Mountain National Park suggested that the aspen population is declining due to intensive browsing by elk (Cervus elaphus). These studies were conducted in the elk winter range, an area of intensive elk impact. The elk summer range experiences less intense grazing pressure. We tested the hypothesis that impacts of elk would be greater in the elk winter range than the summer range with landscape-scale data from the Park. The detrimental effects of elk on aspen are highly localized and, at larger spatial scales, elk browsing does not seem to be influencing the aspen population