Student and School Indicators for Youth in California's Central Valley

Provides a statistical portrait of elementary, secondary, and postsecondary education in the Central Valley. Examines trends in school resources, course enrollment, and student achievement in the region, and compares to trends in the rest of the state

Exploring Point of Sale Strategies for Improving Seafood Retailing: The Case of the Australian Oyster Industry

The commodification of many food products, combined with increasing market share of supermarkets, has increased the importance of point of sale (POS) strategies in speciality food retailers such as fishmongers. The purpose of this study is to develop strategies to improve the retailing of seafood in fishmongers, specifically oysters, a species which is currently underutilised; as although they are eaten by many consumers, purchase frequency is low. A literature review identifies the key drivers and barriers to oyster consumption and the information consumers want at the POS. Based on these findings, a retailing strategy for oysters is developed and tested in two consumer focus groups. Based on focus group results, revisions are recommended to the retail strategy, importantly including a change in collateral from a production focus to a consumption focus. This study makes a clear contribution to theory and practice by bringing together the existing literature on drivers and barriers and consumer information requirements about oysters to develop and test practical retail strategy concepts

Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

The Role of Habit, Childhood Consumption, Familiarity and Attitudes Across Seafood Consumption Segments in Australia

Australian consumers hold very favorable attitudes toward seafood, with key drivers to consumption being taste, convenience, diet variety, and health benefits. Nevertheless, despite these positive attitudes, seafood consumption remains below many other countries. In this article, we investigate the influence of habit including regular childhood consumption, familiarity with seafood, and attitudes toward seafood on seafood consumption and consumption occasions. Habit and lack of familiarity with seafood were found to lead to lower levels of seafood consumption, whereas positive attitudes toward seafood were associated with more regular seafood consumption. People who consumed seafood on a regular basis as a child were more likely to be more familiar with seafood and be in the habit of consuming seafood in adulthood. Patterns of childhood consumption occasions were found to be associated with adult consumption occasions. Based on these findings, we discuss possible strategies and behavioral interventions for further investigation, which are grounded in habit theory and are aimed at changing seafood eating habits, increasing childhood consumption, and reducing the lack of familiarity with seafood

Single Parameter Driven Tunable Resource Allocation for Machine Learning Tasks

Machine learning tasks, such as natural language processing evaluations, are assigned to server resources by dividing the tasks into a number of queues. In such an environment, different tasks may have different priorities, e.g., production tasks may be higher priority than research tasks. Task scheduling mechanisms such as weighted round-robin or batch scheduling are approximate, non-deterministic, and cannot be tuned based on the real time availability of resources. This disclosure describes the use of a single resource optimization parameter, determined based on real time resource availability to establish quantiles based on the exponential distribution for the single parameter. Task queues are updated based on the single parameter and the established quantiles. By updating the single parameter based on real-time availability of resources and workloads, the described techniques provide a tunable mechanism for task scheduling

Insurance Law - Wrongful Conduct of Insured - Innocent Con-Insured

The Pennsylvania Supreme Court has held that the wrongful conduct of one co-trustee in setting fire to a building constituting part of the corpus of a family trust cannot fairly be imputed to other co-trustees so as to deny them recovery of their share of insurance proceeds. Giacobetti v. Insurance Placement Facility of Pennsylvania, ___ Pa. ___, 457 A.2d 853 (1983)

Endogenous Attention and the Spread of False News

We study the impact of endogenous attention in a dynamic model of social media sharing. Each period, a distinct user randomly draws a story from the pool of stories on the platform and decides whether or not to share it. Users want to share stories that are true and interesting, but differentiating true stories from false ones requires attention. Before deciding whether to share a story, users choose their level of attention based on how interesting the story is and the platform's current proportions of true and false stories. We characterize the limit behavior of the share of true stories using stochastic approximation techniques. For some parameter specifications, the system has a unique limit. For others, the limit is random -- starting from the same initial conditions, the platform may end up with very different proportions of true and false stories and different user sharing behavior. We present various comparative statics for the limit. Endogenous attention leads to a counterbalancing force to changes in the credibility of false stories but can intensify the effects of changes in false stories' production rate

Structural features and formation of lower Cretaceous AV[1] layer in the Soviet oil field (Tomsk Oblast)

The analysis of the collected geological and geophysical information on AV[1] layer known as Ryabchik formation is carried out. The facial conditions of this formation which define structural features of "Ryabchik" sandstones formations are considered. Maps characterizing permeability and porosity of reservoir are plotted. Areal tracking technique of sand streaks is given

Using cfRNA as a tool to evaluate clinical treatment outcomes in patients with metastatic lung cancers and other tumors

Aim: We report an exploratory analysis of cfRNA as a biomarker to monitor clinical responses in non-small cell lung cancer (NSCLC), breast cancer, and colorectal cancer (CRC). An analysis of cfRNA as a method for measuring PD-L1 expression with comparison to clinical responses was also performed in the NSCLC cohort. Methods: Blood samples were collected from 127 patients with metastatic disease that were undergoing therapy, 52 with NSCLC, 50 with breast cancer, and 25 with CRC. cfRNA was purified from fractionated plasma, and following reverse transcription (RT), total cfRNA and gene expression of PD-L1were analyzed by real-time polymerase chain reaction (qPCR) using beta-actin expression as a surrogate for relative amounts of cfDNA and cfRNA. For the concordance study of liquid biopsies and tissue biopsies, the isolated RNA was analyzed by RNAseq for the expressions of 13 genes. We had to close the study early due to a lack of follow-up during the Covid-19 pandemic. Results: We collected a total of 373 blood samples. Mean cfRNA PCR signals after RT were about 50-fold higher than those of cfDNA. cfRNA was detected in all patients, while cfDNA was detected in 88% of them. A high concordance was found for the expression levels of 13 genes between blood and solid tumor tissue. Changes in cfRNA levels followed over the course of treatments were associated with response to therapy, increasing in progressive disease (PD) and falling when a partial response (PR) occurred. The expression of PD-L1 over time in patients treated with immunotherapy decreased with PR but increased with PD. Pre-treatment levels of PD-L1 were predictive of response in patients treated with immunotherapy. Conclusion: Changes in cfRNA correlate with clinical response to the therapy. Total cfRNA may be useful in predicting clinical outcomes. PD-L1 gene expression may provide a biomarker to predict response to PD-L1 inhibition

Conditional Ablation of Macrophages Halts Progression of Crescentic Glomerulonephritis

The presence of macrophages in inflamed glomeruli of rat kidney correlates with proliferation and apoptosis of resident glomerular mesangial cells. We assessed the contribution of inflammatory macrophages to progressive renal injury in murine crescentic glomerulonephritis (GN). Using a novel transgenic mouse (CD11b-DTR) in which tissue macrophages can be specifically and selectively ablated by minute injections of diphtheria toxin, we depleted renal inflammatory macrophages through days 15 and 20 of progressive crescentic GN. Macrophage depletion reduced the number of glomerular crescents, improved renal function, and reduced proteinuria. Morphometric analysis of renal tubules and interstitium revealed a marked attenuation of tubular injury that was associated with reduced proliferation and apoptosis of tubular cells. The population of interstitial myofibroblasts decreased after macrophage depletion and interstitial fibrosis also decreased. In the presence of macrophages, interstitial myofibroblasts exhibited increased levels of both proliferation and apoptosis, suggesting that macrophages act to support a population of renal myofibroblasts in a high turnover state and in matrix deposition. Finally, deletion of macrophages reduced CD4 T cells in the diseased kidney. This study demonstrates that macrophages are key effectors of disease progression in crescentic GN, acting to regulate parenchymal cell populations by modulating both cell proliferation and apoptosis