A report about a case of Gestational trophoblastic tumor associated with ectopic pregnancy

مقدمه: تومور تروفوبلاستیک حاملگیGTT)) متعاقب حاملگی خارج رحمی یک رویداد بسیار نادر است. در این مقاله یک مورد مول مهاجم که از یک حاملگی خارج رحمی لوله‌ای نشأت گرفته بود معرفی می‌شود. گزارش مورد: بیمار خانم 26 ساله با حاملگی دوم و اولین حاملگی خارج رحمی (G2L1EP1) بود که به خاطر افزایش میزان هورمون گنادوتروپین جفتی((BHCG بعد از عمل حاملگی خارج رحمی (EP) به بیمارستان شهید بهشتی اصفهان ارجاع شد. درمان اولیه EP بیمار با عمل سالپنژکتومی بوده است. پیگیری پاتولوژی سالپنژکتومی مول مهاجم تشخیص داده شد که بیمار تحت دو دوره درمان با متوترکسات قرار گرفت و با توجه به گزارش توده در آدنکس راست در سونوگرافی یک نوبت لاپاراتومی ‌شد که باز هم تشخیص مول مهاجم بود. بنابراین بیمار تحت رژیم درمانی (etoposide methotrexate actinomycin D cyclophosphamide vincristine) EMA/CO قرار گرفت و نهایتاً با BHCG معادل 1 مرخص شد. نتیجه گیری: پیگیری عدد BHCG بعد از عمل جراحی EP هم برای تشخیص EP پا برجا و هم برای رد GTT بسیار مهم است هم چنین پیگیری جواب پاتولوژی اعمال جراحی در صورتی که از تشخیص نیز مطمئن هستیم ضرورت دارد

A wideband trapezoidal dielectric resonator antenna with circular polarization

A new design of a circularly-polarized (CP) trapezoidal dielectric resonator antenna (DRA) for wideband wireless application is presented. A single-layered feed is used to excite the trapezoidal shaped dielectric resonator to increase resonant frequency and axial ratio. Besides its structure simplicity, ease of fabrication and low-cost, the proposed antenna features good measured impedance bandwidth, 87.3% at 4.21 GHz to 10.72 GHz frequency bands. Moreover, the antenna also produces 3-dB axial ratio bandwidth of about 710 MHz from 5.17 GHz to 5.88 GHz. The overall size of DRA is 21 mm × 35 mm, which is suitable for mobile devices. Parametric study and measurement results are presented and discussed. Very good agreement is demonstrated between simulated and measured results

Wideband P-Shaped Dielectric Resonator Antenna

A novel P-shaped dielectric resonator antenna (DRA) is presented and investigated for wideband wireless application. By using P-shaped resonator, a wideband impedance bandwidth of 80% from 3.5 to 8.2 GHz is achieved. The antenna covers all of wireless systems like C-band, 5.2, 5.5 & 5.8 GHz-WLAN & WiMax. The proposed antenna has a low profile and the thickness of the resonator is only 5.12 mm, which is 0.06-0.14 free space wavelength. A parametric study is presented. The proposed DRA is built and the characteristics of the antenna are measured. Very good agreement between numerical and measured results is obtained

A New Wideband Circularly Polarized Dielectric Resonator Antenna

A wideband and compact circularly polarized (CP) C-shaped dielectric resonator antenna (DRA) is presented. The proposed C-shaped DR is excited by a simple stripe line connected to a coplanar waveguide (CPW) feeding line. The C-shaped DRA is circularly polarized with 19% axial ratio (AR) bandwidth. It is found that the CP bandwidth can be expanded by using a narrow short circuit strip. The final design achieves CP with 50% AR bandwidth. The proposed circularly polarized DRA (CPDRA) with good radiation characteristics offers an impedance bandwidth of 58% between 3.45 and 6.26 GHz for VSWR ≤ 2. The proposed DRA is fabricated and tested. Very good agreement between simulated and measured results is obtained

Environmental effects of the cold water fish farms effluents on the water quality of Gamasyab River as their main source of water supply in the west of Iran

Rainbow trout (Oncorhynchus mykiss) is one of the most-widely cultivated cold fresh water fish in the world. Gamasyab River, with a length of about 200 Km, is one of the longest rivers of Iran. The aim of this research is to determine the effects of trout farm effluents on this river water. From a total of 24 trout farms in the area, four farms were randomly selected and three sampling stations were chosen at each selected farm. Measured water quality parameters were temperature (T), total suspended solids (TSS), total dissolved solid (TDS), dissolved oxygen (DO), pH, five-day biochemical oxygen demand (BOD_5), chemical oxygen demand (COD), ammonia-nitrogen (NH_4-N), nitrate-nitrogen (NO_3-N) and phosphates (PO_4-P). Based on the laboratory analysis, DO in the river water was more than 6 mg/l in all cases. There were significant differences in six variables of T, BOD, COD, NO_3-N, NH_4-N, and TSS of all water samples taken from the second sampling stations between dry and wet season. The DO concentration in Gamasyab River decreased between the water inlet (first stations) and outlet (second stations), but increased in third station. Trout farm effluents had significant impact on the TSS content of the river. This significant increase in TSS concentrations is expected to have occurred due to cleaning or harvesting activities on any of the farms. The results of the study showed that, in all of season, the amount of TSS in the second stations was not equal to the standards of the Department of Environment Protection (40 mg/L) for discharging into river systems

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.

Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART), and published data demonstrating that the human carbohydrate-binding immunomodulatory protein galectin-9 regulates p21, we hypothesized that galectin-9 modulates HIV transcription. We report that the administration of a recombinant, stable form of galectin-9 (rGal-9) potently reverses HIV latency in vitro in the J-Lat HIV latency model. Furthermore, rGal-9 reverses HIV latency ex vivo in primary CD4+ T cells from HIV-infected, ART-suppressed individuals (p = 0.002), more potently than vorinostat (p = 0.02). rGal-9 co-administration with the latency reversal agent "JQ1", a bromodomain inhibitor, exhibits synergistic activity (p<0.05). rGal-9 signals through N-linked oligosaccharides and O-linked hexasaccharides on the T cell surface, modulating the gene expression levels of key transcription initiation, promoter proximal-pausing, and chromatin remodeling factors that regulate HIV latency. Beyond latent viral reactivation, rGal-9 induces robust expression of the host antiviral deaminase APOBEC3G in vitro and ex vivo (FDR<0.006) and significantly reduces infectivity of progeny virus, decreasing the probability that the HIV reservoir will be replenished when latency is reversed therapeutically. Lastly, endogenous levels of soluble galectin-9 in the plasma of 72 HIV-infected ART-suppressed individuals were associated with levels of HIV RNA in CD4+ T cells (p<0.02) and with the quantity and binding avidity of circulating anti-HIV antibodies (p<0.009), suggesting a role of galectin-9 in regulating HIV transcription and viral production in vivo during therapy. Our data suggest that galectin-9 and the host glycosylation machinery should be explored as foundations for novel HIV cure strategies

Self-burning: A common and tragic way of suicide in fars province, Iran

Self-burning is the most devastating burn injury. It is a common social and medical problem in Iran. In a longitudinal prospective study, from April 2003 to March 2006, all burn patients admitted to Ghotb-eddin burn Hospital were enrolled in this study. Suicide attempts by burning accounted for 283 (21.9%) of all burn patients admitted to the hospital. Most (68.2%) of self-burning patients were female. Self-burn patients had significantly large burned body surface area (64.8±29%). Suicidal burns occurred predominantly in the age group 15-24 years (44.6%). The mortality rate for suicidal burns was (60.4%). Fars is a province composed of many different tribes and cultural minorities whereby major decisions are made by forums of clergymen. It is important to involve those clergymen in burn prevention programs to achieve a meaningful reduction in Self-burning prevalence

Esophageal cancer in Iranian Turkmens: An ethnic disparity concern

The association between ethnic diversity in Turkmen population with esophageal cancer incidence in Iranian Turkmens (Golestan province) was trying to explore in the present study. This is a cross sectional study in Turkmen patients with confirmed diagnosis of esophageal cancer between 2002 through 2003 at a referral clinic in Gonbad. One hundred and six Turkmen patients, diagnosed with esophageal cancer by endoscopy and biopsy, were included. Demographic factors (sex and age), cancer histology (SCC and adenocarcinoma), tumor origin (upper 3rd, middle 3rd and lower 3rd of esophagus) and patients' contact numbers were retrieved and the patients were categorized into five different groups based on their ethnicity: Ahtahbai, Jafarbai, Googlan, others and unidentified ethnic group. Incidence rate was estimated based on the number of patients and population of each ethnic group. Descriptive statistics was performed and data were analyzed by Kruskal-Wallis Test for continuous variables and Chi-square Test for categorical variables. A total of 106 Turkmen patients with mean age of 64.22±12.12 (61 male and 45 female) were included in this study. Frequency for each ethnic group was identified as: Ahtahbai (n = 31, 29.2%), Googlan (n = 30, 28.3%), Jafarbai (n = 27, 25.5%), others (n = 7, 6.6%) and unidentified ethnic group (n = 11,10.4%). The mean age and gender were not significantly different between these ethnic groups. Heterogeneity was found within Turkmen population, Ahthabai having least and Googlan highest esophageal cancer incidence rate. As esophageal cancer is very common in Turkmen population and with the high incidence rate in Googlan, this ethnic group needs to be more targeted for the esophageal cancer-screening programme. Further population-based studies can better explore possible factors in different Turkmen ethnic groups

Spine deviations and orthodontic treatment of asymmetric malocclusions in children

Background: The aim of this randomized clinical trial was to assess the effect of early orthodontic treatment for unilateral posterior cross bite in the late deciduous and early mixed dentition using orthopedic parameters. Methods: Early orthodontic treatment was performed by initial maxillary expansion and subsequent activator therapy (Münster treatment concept). The patient sample was initially comprised of 80 patients with unilateral posterior cross bite (mean age 7.3 years, SD 2.1 years). After randomization, 77 children attended the initial examination appointment (therapy = 37, control = 40); 31 children in the therapy group and 35 children in the control group were monitored at the follow-up examination (T2). The mean interval between T1 and T2 was 1.1 years (SD 0.2 years). Rasterstereography was used for back shape analysis at T1 and T2. Using the profile, the kyphotic and lordotic angle, the surface rotation, the lateral deviation, pelvic tilt and pelvic torsion, statistical differences at T1 and T2 between the therapy and control groups were calculated (t-test). Our working hypothesis was, that early orthodontic treatment can induce negative therapeutic changes in body posture through thoracic and lumbar position changes in preadolescents with uniltaral cross bite. Results: No clinically relevant differences between the control and the therapy groups at T1 and T2 were found for the parameters of kyphotic and lordotic angle, the surface rotation, lateral deviation, pelvic tilt, and pelvic torsion. Conclusions: Our working hypothesis was tested to be not correct (within the limitations of this study). This randomized clinical trial demonstrates that in a juvenile population with unilateral posterior cross bite the selected early orthodontic treatment protocol does not affect negatively the postural parameters