Justification of the Main Pedagogical Conditions of Interactive Teaching a Foreign Language in High School

This research paper was conducted to examine the main pedagogical conditions in the organization of interactive teaching at higher education system. Today, the interactive learning is widely used in all aspects of the educational process: at colleges, at the universities, in courses and workshops, because this technique is extremely effective not only in terms of acquiring knowledge, but also by the personal skills formation, we decided to reveal four pedagogical conditions of interactive teaching and its organization for teaching foreign language competence in high school. The use of interactive forms, methods, approaches and new information technology in the classroom for foreign language provide ample opportunity for the formation of the students the knowledge and skills that will grow into the necessary professional foreign language competence of teachers

La redefinición del campo pedagógico : Una perspectiva en relación a sus problemas contemporáneos

Nos proponemos en este resumen dar cuenta de los debates que el Colectivo Docente Educación II viene realizando - a través de diversas actividades - de la configuración del campo pedagógico y de los problemas más relevantes para la formación de los estudiantes de grado en la Carrera de Ciencias de la Educación. Realizaremos una breve enunciación de aquellos que - geopolíticamente y en la actualidad - se nos presentan como más significativos. Los debates teóricos y epistemológicos que fundamentan el recorte realizado serán incluidos en la ponencia correspondiente. El problema del poder, el cambio y la permanencia en los procesos, prácticas, instituciones y sujetos pedagógicos. Las transformaciones sociales, económicas, políticas, culturales y tecnológicas y los cambios en la educación. Las discusiones en torno de las reformas educativas y las innovaciones pedagógicas, la gramática/cultura escolar, las formas de lo escolar, el "programa institucional" como analizadores de las mismas. Los sistemas educativos como construcciones sociales e históricas, como organizaciones complejas, y como institucionalización de prácticas pedagógicas. Continuidades y rupturas en los procesos de emergencia, consolidación y crisis de los sistemas escolares y de los procesos educativos en diversos contextos sociales y pedagógicos. El problema de la desigualdad educativa y los sujetos de la educación. Aproximaciones clásicas y contemporáneas. Del discurso de la igualdad al discurso de la equidad y los debates contemporáneos en torno al discurso de la igualdad. Del problema de la desigualdad al reconocimiento de las diferencias y las identidades: universalismo, particularismo e identidades sociales. Las reformulaciones en torno del problema de la inclusión y la exclusión educativas. La fragmentación de los sistemas escolares y la diversificación de procesos pedagógicos en múltiples contextos de aprendizaje. Los "nuevos" sujetos sociales y educativos y las tensiones en el campo pedagógico: las nuevas infancias, adolescencias y juventudes; la emergencia de movimientos sociales y territoriales en el campo de la educación popular; los movimientos pedagógicos, las redes escolares y las nuevas formas de organización colectiva de docentes. El problema de la transmisión cultural y de los saberes escolares. Aproximaciones clásicas: los sistemas educativos, la transmisión cultural y el currículum como campo de lucha y de construcción hegemónica. Aproximaciones contemporáneas: el "giro cultural" y las redefiniciones epistemológicas y ontológicas de los saberes y el conocimiento. Los docentes: la transmisión cultural y la creación/recreación de los saberes pedagógicos. Del discurso de la homogeneidad universalista al reconocimiento del otro y de la diversidad: el problema del etnocentrismo en educación. La colonialidad del saber, el poder y nuevos problemas pedagógicosFil: Caride, Lucia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.Fil: Thisted, Sofía. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.Fil: Vassiliades, Alejandro. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina

Bimetallic Pt(II)-bipyridyl-diacetylide/Ln(III) tris-diketonate adducts based on a combination of coordinate bonding and hydrogen bonding between the metal fragments: syntheses, structures and photophysical properties

The luminescent Pt(II) complex [Pt(4,4'-Bu-t(2)-bipy){CC-(5-pyrimidinyl)}(2)] (1) was prepared by coupling of [Pt(4,4'-Bu-t(2)-bipy)Cl-2] with 5-ethynyl-pyrimidine, and contains two pyrimidinyl units pendant from a Pt(H) bipyridyl diacetylide core; it shows luminescence at 520 nm which is typical of Pt(II) luminophores of this type. Reaction with [Ln(hfac)(3)(H2O)(2)] (hfac = anion of hexafluoroacetylacetone) affords as crystalline solids the compounds [1 center dot {Ln(hfac)(3)(H2O)}{Ln(hfac)(3)(H2O)(2)}] (Ln = Nd, Gd, Er, Yb), in which the {Ln(hfac)(3)(H2O)} unit is coordinated to one pyrimidine ring via an N atom, whereas the {Ln(hfac)(3)(H2O)(2)} unit is associated with two N atoms, one from each pyrimidine ring of 1, via N center dot center dot center dot HOH hydrogen-bonding interactions involving the coordinated water ligands on the lanthanide centre. Solution spectroscopic studies show that the luminescence of 1 is partly quenched on addition of [Ln(hfac)(3)(H2O)(2)] (Ln = Er, Nd) by formation of Pt(II)/Ln(III) adducts in which Pt(II)-> Ln(III) photoinduced energy-transfer occurs to the low-lying f-f levels of the Ln(Ill) centre. Significant quenching occurs with both Er(Ill) and Nd(III) because both have several f-f states which match well the (MLCT)-M-3 emission energy of 1. Time-resolved luminescence studies show that Pt(II)-Er(III) energy-transfer (7.0 x 10(7) M-1) is around three times faster than Pt(II)-> Nd(III) energy-transfer (approximate to 2 x 10(7) M-1) over the same distance because the luminescence spectrum of l overlaps better with the absorption spectrum of Er(111) than with Nd(III). In contrast Yb(111) causes no significant quenching of 1 because it has only a single f-f excited level which is a poor energy match for the Pt(II)-based excited state

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of prostate carcinoma.

Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer death among men in the United States. In recent years, several new agents, including cancer immunotherapies, have been approved or are currently being investigated in late-stage clinical trials for the management of advanced prostate cancer. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a multidisciplinary panel, including physicians, nurses, and patient advocates, to develop consensus recommendations for the clinical application of immunotherapy for prostate cancer patients. To do so, a systematic literature search was performed to identify high-impact papers from 2006 until 2014 and was further supplemented with literature provided by the panel. Results from the consensus panel voting and discussion as well as the literature review were used to rate supporting evidence and generate recommendations for the use of immunotherapy in prostate cancer patients. Sipuleucel-T, an autologous dendritic cell vaccine, is the first and currently only immunotherapeutic agent approved for the clinical management of metastatic castrate resistant prostate cancer (mCRPC). The consensus panel utilized this model to discuss immunotherapy in the treatment of prostate cancer, issues related to patient selection, monitoring of patients during and post treatment, and sequence/combination with other anti-cancer treatments. Potential immunotherapies emerging from late-stage clinical trials are also discussed. As immunotherapy evolves as a therapeutic option for the treatment of prostate cancer, these recommendations will be updated accordingly

MET Y1253D-activating point mutation and development of distant metastasis in advanced head and neck cancers

We investigated if the MET-activating point mutation Y1253D influences clinical outcomes in patients with advanced squamous cell carcinoma of the head and neck (HNSCC). The study population consisted of 152 HNSCC patients treated by hyperfractionated radiotherapy alone or concomitant with chemotherapy between September 1994 and July 2000. Tumors were screened for the presence of the MET-activating point mutation Y1253D. Seventy-eight patients (51%) received radiotherapy alone, 74 patients (49%) underwent radiotherapy concomitant with chemotherapy. Median patient age was 54years and median follow-up was 5.5years. Distant metastasis-free survival, local relapse-free survival and overall survival were compared with MET Y1253D status. During follow-up, 29 (19%) patients developed distant metastasis. MET Y1253D was detected in tumors of 21 out of 152 patients (14%). Distant metastasis-free survival (P=0.008) was associated with MET Y1253D. In a multivariate Cox regression model, adjusted for T-category, only presence of MET Y1253D was associated with decreased distant metastasis-free survival: hazard ratio=2.5 (95% confidence interval: 1.1, 5.8). The observed association between MET Y1253D-activating point mutation and decreased distant metastasis-free survival in advanced HNSCC suggests that MET may be a potential target for specific treatment intervention