Magnetic Properties of the Intermediate State in Small Type-I Superconductors

We present simulations of the intermediate state of type-I superconducting films solving the time dependent Ginzburg-Landau equations, which include the demagnetizing fields via the Biot-Savart law. For small square samples we find that, when slowly increasing the applied magnetic field $H_a$, there is a saw-tooth behavior of the magnetization and very geometric patterns, due to the influence of surface barriers; while when slowly decreasing $H_a$, there is a positive magnetization and symmetry-breaking structures. When random initial conditions are considered, we obtain droplet and laberynthine striped patterns, depending on $H_a$.Comment: 4 pages, 5 figures. Accepted for publication in Phys. Rev. B (Rapid

The surface barrier in mesoscopic type I and type II superconductors

We study the surface barrier for magnetic field penetration in mesoscopic samples of both type I and type II superconductors. Our results are obtained from numerical simulations of the time-dependent Ginzburg-Landau equations. We calculate the dependence of the first field for flux penetration ($H_p$) with the Ginzburg-Landau parameter ($\kappa$) observing an increase of $H_p$ with decreasing $\kappa$ for a superconductor-insulator boundary condition ($(\nabla -iA)\Psi|_n=0$) while for a superconductor-normal boundary condition (approximated by the limiting case of $\Psi|_S=0$) $H_p$ has a smaller value independent of $\kappa$ and proportional to $H_c$. We study the magnetization curves and penetration fields at different sample sizes and for square and thin film geometries. For small mesoscopic samples we study the peaks and discontinuous jumps found in the magnetization as a function of magnetic field. To interpret these jumps we consider that vortices located inside the sample induce a reinforcement of the surface barrier at fields greater than the first penetration field $H_{p1}$. This leads to multiple penetration fields $H_{pi} = H_{p1}, H_{p2}, H_{p3}, ...$ for vortex entrance in mesoscopic samples. We study the dependence with sample size of the penetration fields $H_{pi}$. We explain these multiple penetration fields extending the usual Bean-Livingston analysis by considering the effect of vortices inside the superconductor and the finite size of the sample.Comment: 12 pages, 11 figures. Revised version. Section III rewritten. Some figures change

The Orion constellation as an installation - An innovative three dimensional teaching and learning environment

Visualising the three dimensional distribution of stars within a constellation is highly challenging for both students and educators, but when carried out in an interactive collaborative way it can create an ideal environment to explore common misconceptions about size and scale within astronomy. We present how the common table top activities based upon the Orion constellation miss out on this opportunity. Transformed into a walk-through Orion installation that includes the position of our Solar system, it allows the students to fully immerse themselves within the model and experience parallax. It enables participants to explore within the installation many other aspects of astronomy relating to sky culture, stellar evolution, and stellar timescales establishing an innovative learning and teaching environment.Comment: 2 pages, submitted to The Physics Teacher - Colum

Lactate-guided resuscitation saves lives: we are not sure

SCOPUS: ed.jinfo:eu-repo/semantics/publishe

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully characterized. We hypothesized stable isotope metabolomics would identify increased glucose, glutamine and fatty acid uptake and utilization in human PASMCs and PAECs from PH versus control specimens, and that TGF-β treatment would phenocopy these metabolic changes. We used 13C-labeled glucose, glutamine or a long-chain fatty acid mixture added to cell culture media, and mass spectrometry-based metabolomics to detect and quantify 13C-labeled metabolites. We found PH PASMCs had increased glucose uptake and utilization by glycolysis and the pentose shunt, but no changes in glutamine or fatty acid uptake or utilization. Diseased PAECs had increased proximate glycolysis pathway intermediates, less pentose shunt flux, increased anaplerosis from glutamine, and decreased fatty acid β-oxidation. TGF-β treatment increased glycolysis in PASMCs, but did not recapitulate the PAEC disease phenotype. In TGF-β-treated PASMCs, glucose, glutamine and fatty acids all contributed carbons to the TCA cycle. In conclusion, PASMCs and PAECs collected from PH subjects have significant changes in metabolite uptake and utilization, partially recapitulated by TGF-β treatment

Wrapped branes with fluxes in 8d gauged supergravity

We study the gravity dual of several wrapped D-brane configurations in presence of 4-form RR fluxes partially piercing the unwrapped directions. We present a systematic approach to obtain these solutions from those without fluxes. We use D=8 gauged supergravity as a starting point to build up these solutions. The configurations include (smeared) M2-branes at the tip of a G_2 cone on S^3 x S^3, D2-D6 branes with the latter wrapping a special Lagrangian 3-cycle of the complex deformed conifold and an holomorphic sphere in its cotangent bundle T^*S^2, D3-branes at the tip of the generalized resolved conifold, and others obtained by means of T duality and KK reduction. We elaborate on the corresponding N=1 and N=2 field theories in 2+1 dimensions.Comment: 32 pages, LateX, v2: minor changes, reference added, v3: section 3.5.2 improve

Chronic lymphocytic leukemia with clinical debut as neurological involvement: a rare phenomenon and the need for better predictive markers

BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The frequency of symptomatic central nervous system (CNS) involvement is unknown but thought to be a rare phenomenon. Currently there are no known risk factors for CNS involvement. CASE PRESENTATION: We describe a clinically staged low-risk CLL case that presented with symptomatic CNS involvement and progressed rapidly to death. Evaluation of the surface adhesion molecules identified a markedly altered expression pattern of the integrin, CD49d, and the tetraspanin, CD82, in the index case when compared to similar low-risk CLL cases. We found that the early Rai clinical stage CLL patients showed linear correlation for the co-expression of CD82 and CD49d. In contrast, this unique index case with CNS involvement, which has the same Rai clinical stage, had a significantly lower expression of CD82 and higher expression of CD49d. CONCLUSIONS: These data suggest that the expression profile of CD49d and CD82 may represent potential biomarkers for patients with increased propensity of CNS involvement. Moreover, this study illustrates the critical need for a better mechanistic understanding of how specific adhesion proteins regulate the interactions between CLL cells and various tissue sites

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.

Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-synuclein implicated in fatal neurodegenerative disorders. Problematically, potentiated MD variants can exhibit off-target toxicity. Here, we mine disaggregase sequence space to safely enhance Hsp104 activity via single mutations in nucleotide-binding domain 1 (NBD1) or NBD2. Like MD variants, NBD variants counter TDP-43, FUS, and α-synuclein toxicity and exhibit elevated ATPase and disaggregase activity. Unlike MD variants, non-toxic NBD1 and NBD2 variants emerge that rescue TDP-43, FUS, and α-synuclein toxicity. Potentiating substitutions alter NBD1 residues that contact ATP, ATP-binding residues, or the MD. Mutating the NBD2 protomer interface can also safely ameliorate Hsp104. Thus, we disambiguate allosteric regulation of Hsp104 by several tunable structural contacts, which can be engineered to spawn enhanced therapeutic disaggregases with minimal off-target toxicity

Ameliorating Systematic Uncertainties in the Angular Clustering of Galaxies: A Study using SDSS-III

We investigate the effects of potential sources of systematic error on the angular and photometric redshift, z_phot, distributions of a sample of redshift 0.4 < z < 0.7 massive galaxies whose selection matches that of the Baryon Oscillation Spectroscopic Survey (BOSS) constant mass sample. Utilizing over 112,778 BOSS spectra as a training sample, we produce a photometric redshift catalog for the galaxies in the SDSS DR8 imaging area that, after masking, covers nearly one quarter of the sky (9,913 square degrees). We investigate fluctuations in the number density of objects in this sample as a function of Galactic extinction, seeing, stellar density, sky background, airmass, photometric offset, and North/South Galactic hemisphere. We find that the presence of stars of comparable magnitudes to our galaxies (which are not traditionally masked) effectively remove area. Failing to correct for such stars can produce systematic errors on the measured angular auto-correlation function, w, that are larger than its statistical uncertainty. We describe how one can effectively mask for the presence of the stars, without removing any galaxies from the sample, and minimize the systematic error. Additionally, we apply two separate methods that can be used to correct the systematic errors imparted by any parameter that can be turned into a map on the sky. We find that failing to properly account for varying sky background introduces a systematic error on w. We measure w, in four z_phot slices of width 0.05 between 0.45 < z_phot < 0.65 and find that the measurements, after correcting for the systematic effects of stars and sky background, are generally consistent with a generic LambdaCDM model, at scales up to 60 degrees. At scales greater than 3 degrees and z_phot > 0.5, the magnitude of the corrections we apply are greater than the statistical uncertainty in w.Comment: Accepted by MNRA